Dr. Singh Smrita
Hematology
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Patient's Query
Hello doctor,
As suggested by most of the doctor marrying a girl with the same blood group will not cause any problems, in my case the blood group is A+ve. She is my maternal uncle's daughter. She is a close relative. Can our marriage create a reduced genetic pool? Can I marry the girl? Will I have kids if I marry her? Will I have a future kid without genetic defects? What are tests needed to be done if I want to marry the girl in close relation first or second order? As I have read reduced genetic pool can create abnormalities as common genes which are suppressed may become active in the next generation. Please guide in this issue.
Hello,
Welcome to icliniq.com.
As you want to marry within your related family, I would suggest that you get yourself and your fiance genetically tested to estimate the risks based on both your genetic profiles. This will greatly help you with determining the chances of the child having genetic defects.
Patient's Query
Thank you doctor,
Which genetic test needs to be done?
Hello,
Welcome back to icliniq.com.
These recommendations are the opinions of a multicenter working group (the Consanguinity Working Group (CWG)) with expertise in genetic counseling, medical genetics, biochemical genetics, genetic epidemiology, pediatrics, perinatology, and public health genetics, which was convened by the National Society of Genetic Counselors (NSGC). The consensus of the CWG and NSGC reviewers is that beyond a thorough medical family history with follow-up of significant findings, no additional preconception screening is recommended for consanguineous couples.
During pregnancy, consanguineous couples should be offered maternal-fetal serum marker screening and high-resolution fetal ultrasonography. Newborns should be screened for impaired hearing and detection of treatable inborn errors of metabolism. Since, you said that there is a history of a child being born in your family with developmental anomalies, the cause of the malformation should be determined. A thorough family history will be taken by your doctor for at least 3 to 4 generations. Based on the history, further tests will be recommended.
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Hematology
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