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Q. What does the blood test taken for sudden hearing loss indicate?

Answered by Dr. Ashaq Hussain Parrey.


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Hello doctor,

I had a sudden hearing loss twice and because it happened twice, I was sent for a plethora of blood tests. My ANA was negative but I noticed two markers out of range. I was wondering if you could give any insight into these blood test results?


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Dr. Ashaq Hussain Parrey
MBBS., MD
General Medicine, Internal Medicine, Rheumatology

Hello,

Welcome to icliniq.com.

I went through your post and investigations (attachment removed to protect patient identity), there are two things which I presume you think are abnormal. CK (creatine kinase), it is an enzyme produced by heart muscle and skeletal muscle. So, is elevated in people with muscle or heart disease but low levels have no significance and are common in people with a sedentary lifestyle who do not exert much. Anti-histone antibodies are seen in people with drug-induced lupus so if one does not have other features of lupus as in your case the hearing loss is not a criterion for lupus (ACR criteria for SLE). It has little or no importance. I think there is a possibility of Meniere's disease for which you should get investigated that can cause sudden temporary hearing loss.

 

Thank you doctor,

What about the glycoprotein 1 being out of range under lupus testing as well?

 

Dr. Ashaq Hussain Parrey
MBBS., MD
General Medicine, Internal Medicine, Rheumatology

Hi,

Welcome back to icliniq.com.

Anti-beta 2 glycoprotein is a marker of APLA (antiphospholipid antibodies) the diagnosis of which requires two or more abortions or DVT (deep vein thrombosis) unprovoked and it has to be positive again after 12 weeks. Yes, it is a criterion for lupus but one has to fulfill at least four criteria for making the diagnosis of lupus. Secondly, these antibodies are induced by a lot of factors, especially the viral and bacterial infections. So, isolated form have little significance because they rise and fall in short intervals of four weeks.

 
 
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