Which anticoagulant is best to prevent stroke- Apixaban or Dabigatran?

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As per the history, it looks like it is getting difficult to manage with Warfarin. Warfarin is notorious in terms of interacting with many other drugs and thereby it is difficult to achieve the target therapeutic level. So, now newer oral anticoagulants are used with no need of monitoring and without any excess risk of bleeding as compared to Warfarin. There are various papers to confirm that newer oral anticoagulants (NOACs) are safe and effective compared to Warfarin.

So, once we decide that we are switching to NOACs, then we have to see which one is best out of them. For that also, there have been various studies done recently. When we compare, we see two things:

1. Whether the drug is effective or not, it means it should prevent stroke.
2. It should not cause any excess bleeding as well. As they are blood thinners, the risk will always be there.

All the studies will mention these two facts while comparing the drugs. Most of them have quoted that Apixaban as equivalent to other drugs in terms of effectiveness (that is preventing the stroke) and better in terms of side effects (that is lesser risk of excess bleeding).

Regarding the dose, different studies have quoted 2.5 mg BD versus 5 mg BD. So, this will depend on your doctor and his experience with the dose commonly used in your country.

My suggestion is to move to newer oral anticoagulants with a slight inclination towards Apixaban based on the current data.