My calcium levels are high. Will IVF be a failure?

Q. Will frozen embryo transfer be successful if my calcium levels are high?

Answered by
Dr. Reetika
and medically reviewed by Dr. Sneha Kannan
This is a premium question & answer published on Jan 02, 2022 and last reviewed on: Sep 23, 2022

Hello doctor,

I am 37 years old female. My CA level is 103 mm/dL, while the normal level is 35 mm/dL. I am undergoing IVF treatment, and I had hydrosalpinx and ovarian cyst surgery. My CA level was 20 mm/dL with two Lupron depot shots 3.75. I took five Lupron shots this year. A couple of months back, the fresh embryo cycle failed with high CA 103. Will IVF be a failure? My height is 5 feet, and my weight is 64.86 kg.

Thank you.



Welcome to

A high CA (calcium) 125 mm/dL indicates an endometriotic cyst and damage to the ovarian surface due to repeated cysts. It cannot be said that IVF (in-vitro fertilization) will be a failure. A few studies suggest IVF success with higher values. Other factors like egg quality and endometrial health should also be looked into.

Thank you.

Hello doctor,

I want your opinion on the frozen embryo transfer cycle. Is it necessary to reduce the level of CA 125? I am trying FET with donor eggs. Please advise.

Thank you.



Welcome back to

No, reducing levels to less than 35 mm/dL of calcium for FET (frozen embryo transfer) is unnecessary. Since there is a history of endometriosis, it is difficult to get the value within normal limits as there is bound to be some damage or inflammation. Just enquire about the endometrium; if it looks healthy and with good flow, you can go ahead with FET. I hope this helps.

Thank you.

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