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HomeAnswersMedical oncologylung cancerMy stage 4 lung cancer is not improving even with medication. Why?

What is the treatment of stage 4 lung adenocarcinoma?


The following is an actual conversation between an iCliniq user and a doctor that has been reviewed and published as a Premium Q&A.

Medically reviewed by

iCliniq medical review team

Published At January 17, 2024
Reviewed AtJanuary 17, 2024

Patient's Query

Hello doctor,

I was diagnosed with adenocarcinoma lung stage 4 for more than four years now. Thereafter regular treatment as per the treatment sequence attached. I am taking Tecentriq 1200, Beveconumab 800, Genexol PM 300, and Cisplatin 100 mg for six cycles every 21 days. Despite this, the disease is in progression (copy of the last PET scan attached). I have also attached the histopathology report. Kindly suggest your opinion.

Thank you.

Answered by Dr. Rajesh Gulati


Welcome to icliniq.com.

I read your query and can understand your concerns.

It does happen in stage four of lung cancer. Cancer cells become resistant after 3 to 6 cycles. We need to move to the next line of chemotherapy. It is the standard protocol. Tecentriq (Atezolizumab) and Genexol (Paclitaxel) should not be given together. You can go for Atezolizumab, Bevacizumab, and Cisplatin for four cycles, if these agents are not given earlier and repeat the scan after four cycles. If no progression, should plan another four cycles.

Thank you.

Same symptoms don't mean you have the same problem. Consult a doctor now!

Dr. Rajesh Gulati
Dr. Rajesh Gulati

Family Physician

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