Can high doses of Dexamethasone impair the immune system in patient with COVID-19 pneumonia?

Hi,

Welcome to icliniq.com. Thank you for the query. I can understand your concern. According to your statement, your dad is in the intensive care unit (ICU) for his critical health conditions due to Covid pneumonia along with developing atrial fibrillation. High doses of Dexamethasone may impair his immunity system and make him more prone to developing a secondary infection. After assessing your dad's present physical condition, his doctors have decided the amount of Dexamethasone to be used. Again, your dad may develop DIC (Disseminated intravascular coagulation) or any internal bleeding as a complication of COVID-19 infection; for this reason, he is on blood thinners. Oxygen saturation can decline at any time in the case of such types of patients; for that reason, his doctors have planned for intubation. Such patients can deteriorate at any time, and taking foods or drinking fluids through the mouth may cause aspiration pneumonia, a very life-threatening condition. His doctors have advised inserting an NG tube for maintaining his nutrition and electrolytes balance. As his Covid pneumonia has been confirmed, so antiviral medications should be started. Broad-spectrum antibiotics also can be started along with antiviral medicines to prevent from developing any secondary infection. Shifting your dad to another hospital may make worse his physical condition. I think that the doctors are the best judge, and they will make the best decision for your patient's betterment. You should follow your dad's doctor's instructions strictly. Take care. In case of any other query, ask me.

Hi,

Welcome back to icliniq.com. I am extremely sorry for the late reply. As there is no presence of any bacterial infection, so his blood culture has become negative. Antibiotics are usually given as prophylaxis in such types of patients to prevent for development of any further nosocomial or secondary infections. Dexamethasone is usually given for 7-10 days in such types of patients. As the doses and duration of Dexamethasone have already been completed, so your dad's doctors have stopped giving Dexamethasone. Dexamethasone is an anti-inflammatory drug as well as a corticosteroid drug too. Injectable antiviral medications like Remdesivir are used for Covid-19 infected patients in the hospital setting. According to the CXR P/A (Chest x-ray posteroanterior) view that is provided here, your dad is still suffering from Covid pneumonia. But, his Covid pneumonia is starting to heal now.