What could be the cause of persistent joint pain in the hands and knees?

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I went through your query.

Rheumatoid arthritis (RA) is a chronic inflammatory disease that affects the joints, and it can cause joint pain, swelling, and stiffness. If you are experiencing these symptoms, your doctor may recommend some tests to help determine if you have RA. These tests may include:

1. Physical examination: Your doctor will examine your joints to look for signs of inflammation, such as warmth, redness, and swelling.

2. Blood tests: Your doctor may order blood tests to check for the presence of antibodies called rheumatoid factor (RF) and anti-cyclic citrullinated peptide (CCP) antibodies. These antibodies are often present in people with RA.

3. X-rays: Your doctor may order X-rays of your joints to look for signs of joint damage, which can occur in people with RA.

4. Joint fluid analysis: Your doctor may remove fluid from an affected joint and send it to a laboratory for analysis to look for signs of inflammation and infection.

If you are diagnosed with RA, your doctor may recommend medications to help manage your symptoms and prevent further joint damage. Kevzara (Sarilumab) is a medication that is approved by the FDA to treat moderate to severe RA in adults who have not responded well enough to other medications. Kevzara works by blocking the activity of interleukin-6 (IL-6), a protein that plays a role in inflammation.

Studies have shown that Kevzara can significantly reduce joint pain, swelling, and stiffness in people with RA. In clinical trials, approximately 40 percent of people who received Kevzara experienced a significant reduction in disease activity compared to those who received a placebo. However, Kevzara does not provide complete relief from the disease, and some people may still experience joint pain and stiffness while taking the medication.

As with any medication, Kevzara can cause side effects. Some common side effects include:

1. Upper respiratory tract infections: This is the most common side effect reported by people taking Kevzara. Symptoms may include runny nose, sore throat, or cough.

2. High blood pressure: Some people may experience an increase in blood pressure while taking Kevzara. Your doctor will monitor your blood pressure regularly while you're taking the medication.

3. Headache: Some people may experience headaches while taking Kevzara (Sarilumab). These headaches are generally mild to moderate in severity and can be managed with over-the-counter pain relievers.

4. Nausea: Some people may experience nausea while taking Kevzara. This side effect is generally mild to moderate in severity and can be managed with over-the-counter medications or dietary changes.

5. Injection site reactions: Some people may experience redness, itching, or swelling at the injection site after receiving Kevzara. These reactions are generally mild to moderate in severity and can be managed with over-the-counter medications or ice packs applied to the injection site after receiving the medication.

It is important to discuss any potential side effects with your doctor before starting treatment with Kevzara or any other medication for RA. Your doctor can help you weigh the potential benefits and risks of treatment and develop a personalized treatment plan that meets your individual needs and preferences.

I hope this helps.

Thanks and regards.