HomeAnswersObstetrics and GynecologyrubellaI am pregnant. What if IgM is positive and IgG is negative?

I am having rubella infection during my pregnancy. What should I do?


The following is an actual conversation between an iCliniq user and a doctor that has been reviewed and published as a Premium Q&A.

Answered by

Dr. Uzma Arqam

Medically reviewed by

iCliniq medical review team

Published At December 1, 2022
Reviewed AtOctober 16, 2023

Patient's Query

Hi doctor,

I am seven weeks pregnant. After my TORCH test, I came to know that my rubella IgM is 1.22 g/L and HSV is also 1.35 cd/m. Both IgG is negative. What does it mean when IgM is positive, and IgG is negative? What should I do?

Answered by Dr. Uzma Arqam


Welcome to icliniq.com.

I understand your concern.

It would be better if you provided me with your detailed medical history.

  1. IgM positive with IgG negative means you were not immune to the disease and recently got an infection even with antibodies not formed.
  2. If positive in the early 12 weeks of pregnancy, rubella infection remarkably affects fetus development. It causes congenital rubella syndrome, a combination of abnormalities related to sensorineural, ear, eyes, and heart defects. So, unfortunately, it is too dangerous for fetal development as it will affect early pregnancy.
  3. My opinion regarding rubella IgM positive in the first trimester is the termination of pregnancy as rubella affects early development too hazardously.
  4. Congenital herpes very rarely occurs due to transplacental intrauterine infection. Some times difficult to differentiate between primary and secondary herpes more common in HIV (human immunodeficiency virus) positive women.
  5. Genital reactivation of HSV (herpes simplex virus) increases the risk of perinatal transmission. Therefore, oral Acyclovir is only cautiously used in patients less than 20 weeks gestation to reduce symptoms and duration.
  6. Saline bathing and analgesia can be advised for herpes.
  7. The risk of neonatal herpes is small, 1 % to 3 % in women presenting with recurrent genital herpes at the onset of labor.
  8. I have reviewed your report (attachment removed to protect the patient's identity). I suggest you consult your specialist doctor, discuss with them, and take the medicines with their consent, as you may need termination after full discussion and proper counseling. If you want to continue the pregnancy outcome could be stillbirth, intrauterine fetal death, or a child with multiple anomalies.
  9. Rubella immunization during pregnancy can be used as a preventive measure.

Same symptoms don't mean you have the same problem. Consult a doctor now!

Dr. Uzma Arqam
Dr. Uzma Arqam

Obstetrics and Gynecology

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