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Usually, in sickle cell anemia, blood transfusion is not needed. The prognosis depends on the severity of sickle cell. Dehydration, infection is a usual precipitant for sickle cell anemia. So it is better to avoid them and whenever having such incident, consult a doctor immediately. Sickle cell anemia patient's median age can be considered between 50 to 60 years but still, the exact specific prognosis cannot be predicted.