Can Thiazide diuretics worsen spinal disc degeneration?

Question

Hello doctor,

I have degenerated spinal discs and have recently begun taking Thiazide diuretics due to excessive calcium loss through urine. Could the diuretic result in water being drawn from the spinal discs, potentially hastening their degeneration? I am concerned that the diuretic might contribute to quicker drying of the discs. Please help.

Thank you.

Answer 1

Hi,

Welcome to icliniq.com.

Thank you for reaching out, and I understand your concern.

Thiazide diuretics can lead to dehydration, primarily affecting the extracellular fluid compartment in the body. According to biochemical and physiological mechanisms, there is generally no cause for concern regarding dehydration side effects, especially when diuretics are used in prolonged high doses. The impact on the turgidity (state of being swollen or distended) of the spinal disc is expected to be minimal. Spinal discs are avascular, and the water within them is contained in the nucleus, the central part of the disc, through a hygroscopic protein matrix.

Rest assured, I suggest you do not worry about the diuretic-induced dehydration significantly affecting the hydration of the disc. Any symptoms of dehydration are likely to manifest before having any noticeable effect on the disc's hydration.

I hope this information will help you.

Please revert in case of further queries.

Thank you.

Answer 2

Hi,

Welcome back to icliniq.com.

I read your query and can understand your concern.

Taking 2.5 mg of Centyl (Bendroflumethiazide) is a low dose. Back pain is caused by many things, like getting older, not exercising, being overweight, and even genetics. It is not just one thing causing it. Diuretics are not a big factor in this. They only play a small part.

I hope this helps.

Please revert in case of further queries.

Thank you.