Thalassemia

Thalassemia is a blood disorder where the body produces an abnormal form of hemoglobin. It is an inherited disorder and is caused by either genetic mutation or deletion of some gene fragments. The symptoms are bone deformities, dark urine, tiredness, pale and yellowish skin, and poor or delayed growth.

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What is the possibility of a baby acquiring thalassemia major from parents having hemoglobin E disease?

Query: Hi doctor, My wife and I are both 29 years old. I have been diagnosed with hemoglobin E disease. My hemoglobin A is 68.7 g/dL, hemoglobin F is 9 g/dL, and hemoglobin E and A2 are 26 g/dL. And my wife has been diagnosed with a hemoglobin E trait. Her hemoglobin A is 9.1 g/dL and hemoglobin E and A2 a...  Read Full »


Dr. Parth R Goswami

Answer: Hi, Welcome to icliniq.com. I have gone through your attached reports (attachment removed to protect patient identity) and history. Hemoglobin E disease or trait is an autosomal recessive condition. You are hemoglobin E disease patient, which means you are homozygous, and your wife has hemoglobin ...  Read Full »

What does it mean when MCV and MHV are low after delivery?

Query: Hello doctor, I am a 24-year-old female. I have a 8-month-old baby. I am suffering from a thickened uterine lining (18 mm) and experiencing heavy bleeding for the last three months. After using hormonal pills (Ovipauz) for one month, the lining returned to a normal thickness of 6 mm, but I still ha...  Read Full »


Dr. Parth R Goswami

Answer: Hello, Welcome to icliniq.com. Following is my opinion for your questions; In pregnancy, hemoglobin level usually goes down, so do not worry about that. In the attached reports (attachments removed to protect the patient’s identity), your hemoglobin level is low, along with low PCV (pa...  Read Full »

Kindly go through my blood report and suggest the type of thalassemia.

Query: Hi doctor,I have attached a report. I just want to know if this hemoglobin electrophoresis result is beta thalassemia minor or beta thalassemia intermedia or beta thalassemia major.  Read Full »


Dr. Parth R Goswami

Answer: Hi, Welcome to icliniq.com. According to HPLC report (high-performance liquid chromatography), you have attached, HbA2 raised and HbA decreased (hemoglobin A2 and A). Hence, it is suggestive towards thalassemia minor (attachment removed to protect patient identity). It does not look like thalassemi...  Read Full »

Is low iron, hemoglobin, and hematocrit in blood tests indicative of anemia?

Query: Hi doctor, I need an interpretation from a hematologist on recent laboratory results. I am feeling fine, but results show low iron, hemoglobin, hematocrit, etc. I have copies of three recent reports from different laboratories. Also, I donated blood twice in the last and the previous month. I am no...  Read Full »


Dr. Mubashir Razzaq Khan

Answer: Hi, Welcome to icliniq.com. I hope you are safe and sound in the pandemic. I reviewed all of your investigations in the past couple of months (attachments removed to protect the patient's identity). 1) You have developed iron deficiency which later leads to anemia (low hemoglobin). 2) You donate...  Read Full »

Can thalassemia minor be treated?

Query: Hi doctor,I am a 20-year-old male with a weight of 70 kilograms and a height of five feet six inches. I have a thalassemia minor and I would like to know the treatment for it. Please advise. How can I improve my health? I have paleness, hair loss, and rapid fatigue. I am taking Folic acid tablets an...  Read Full »


Dr. Ashish Jayanand Chandwadkar

Answer: Hi, Welcome to icliniq.com. According to your history and complaints, there is no treatment for thalassemia minor currently but there are many treatments for thalassemia major and it is not needed for minor forms. Symptomatic treatment and supportive therapy are advised. To improve your health...  Read Full »

Why my dad's hemoglobin level drops constantly?

Query: Hello doctor,A year ago, my dad was diagnosed with anemia after his hemoglobin levels dropped to 4 g/L. Since then, he has received two blood transfusions and several iron infusions. He has had several tests done to rule out any major illnesses, and all came back normal. For the time being, the tran...  Read Full »


Dr. Anshul Varshney

Answer: Hi, Welcome to icliniq.com. Now see anemia iron deficiency is due to two factors. First is that body is losing the iron stores through some bleeding, and for that, endoscopy and colonoscopy have been performed, and no reasons are found. So, we should concentrate on the second factor: productio...  Read Full »

What conditions can result in low levels of serum iron?

Query: Hi doctor, I had my hemoglobin, CBC and iron test. The result indicates that I have low hemoglobin. However, my iron level is normal (122). I am confused to take the next step. I have been eating spinach, beans and red meat. Also, I am taking iron supplements. What to do further? Please suggest me.  Read Full »


Dr. Veerendra Patil

Answer: Hello, Welcome to icliniq.com. It is evident that you have low hemoglobin with low MCV (attachment removed to protect patient identity). Low MCV (mean corpuscular volume) means that your red blood cells (RBC) are small in size, which is more commonly seen in iron deficiency anemia. There are other c...  Read Full »

Can beta-thalassemia minor be treated?

Query: Hi doctor, One of my daughters has got beta thalassemia major and G6PD deficiency. Is there any treatment for her? Please advice.  Read Full »


Dr. Geetha Priyadarsini Kamminana

Answer: Hello, Welcome to icliniq.com. Beta thalassemia major includes a hereditary disorder and is due to genetic deficiency of beta globin chains of hemoglobin. It is transfusion dependent anemia.Management of beta thalassemia major includesChronic transfusion to maintain hemoglobin at the range of 9-10 ...  Read Full »

Does the relationship DNA test get affected by beta-thalassemia minor?

Query: Hi doctor, I am beta thalassemia minor. If I go for a relationship DNA test with my son, will the DNA report be false due to this?  Read Full »


Dr. Prakash H Muddegowda

Answer: Hi, Welcome to icliniq.com. Based on your query, my opinion is as follows: No, relationship DNA test will not be affected. It is autosomal related. He may or may not be a carrier. DNA test will look at multiple patterns. If you want, you can go for DNA test. Being affected from thalassemia is not go...  Read Full »

Please suggest a diet chart for thalassemia patient.

Query: Hi doctor, My brother is a thalassemia major subject. His age is 18 years and height is 5'4''. His hemoglobin is always maintained between 9 and 10 units. His weight is 38 now and drastically reducing. Nowadays he has been having headache and fever now and then. Sometimes he feels that his heartbeat...  Read Full »


Dr. Prakash H Muddegowda

Answer: Hi, Welcome to icliniq.com. Based on your query regarding thalassemia, my opinion is as follows:1. Looking at a regular hemoglobin level of 9-10%, I would suggest you increase the levels. Maintaining at this level increases further erythropoiesis (production of red blood cells). Close to 12-13 g% ...  Read Full »

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