Thalassemia is a blood disorder where the body produces an abnormal form of hemoglobin. It is an inherited disorder and is caused by either genetic mutation or deletion of some gene fragments. The symptoms are bone deformities, dark urine, tiredness, pale and yellowish skin, and poor or delayed growth.

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Mine and my wife's blood group is B. Will it cause any problem in our married life?

Query: Hello doctor, My wife's and mine blood groups are the same. Both of our blood group is B. Will there be any problem in our married life?  Read Full »

Dr. Goswami Parth Rajendragiri

Answer: Hi, Welcome to There are two major blood group systems. ABO - According to this system, the blood group can be A, B, O, or AB. Rh system - According to this system, the blood group can be Rh positive or negative. You have not mentioned the Rh grouping. You both have the same blo...  Read Full »

Kindly go through my blood report and suggest the type of thalassemia.

Query: Hi doctor, I have attached a report. I just want to know if this hemoglobin electrophoresis result is beta thalassemia minor or beta thalassemia intermedia or beta thalassemia major.  Read Full »

Dr. Goswami Parth Rajendragiri

Answer: Hi, Welcome to According to HPLC report (high-performance liquid chromatography), you have attached, HbA2 raised and HbA decreased (hemoglobin A2 and A). Hence, it is suggestive towards thalassemia minor (attachment removed to protect patient identity). It does not look like thalass...  Read Full »

Which is the best diet for someone with thalassemia major?

Query: Hi doctor,I am a patient of thalassemia major. My first blood transfusion was four months ago. There was no need for blood transfusion before that. I have no idea about my disease and now my blood transfusion has reached a count of eight times, meaning eight units in the last three months. I checked...  Read Full »

Dr. Singh Smrita

Answer: Hello, Welcome to In thalassemia major, there is a defect in the production of normal hemoglobin. This affects the oxygen-carrying capacity of the hemoglobin since it is defective. Regular blood transfusions and iron chelation therapy to prevent iron overload is the main treatment. Yo...  Read Full »

What diet will you recommend for a beta major thalassemia patient?

Query: Hi doctor,My daughter, who is 2.5 years old, is suffering from beta major thalassemia. From her three months of age, blood has been transfused either once in 30 or 45 days after checking the blood level. I would request you to kindly advise a good and healthy food diet. Is there any important daily ...  Read Full »

Dr. Prakash H. M

Answer: Hi,Welcome to on your query, my opinion is as follows:Thalassemia is a disease due to reduced globin production in the hemoglobin part of RBC (red blood cells). It is not due to nutritional deficiency, but due to inherited mutation abnormalities.Yes, nutrition requires improvement....  Read Full »

What conditions can result in low levels of serum iron?

Query: Hi doctor, I had my hemoglobin, CBC, and iron test. The result indicates that I have low hemoglobin. However, my iron level is normal. I am confused about taking the next step. I have been eating spinach, beans, and red meat. Also, I am taking iron supplements. What to do further? Would you please ...  Read Full »

Dr. Veerendra Channabasappa Patil

Answer: Hello, Welcome to It is evident that you have low hemoglobin with low MCV (attachment removed to protect patient identity). Low MCV (mean corpuscular volume) means that your red blood cells (RBC) are small in size, which is more commonly seen in iron deficiency anemia. There are other c...  Read Full »

Does the relationship DNA test get affected by beta-thalassemia minor?

Query: Hi doctor, I am beta thalassemia minor. If I go for a relationship DNA test with my son, will the DNA report be false due to this?  Read Full »

Dr. Prakash H. M

Answer: Hi, Welcome to Based on your query, my opinion is as follows: No, a relationship DNA test will not be affected. It is autosomal related. He may or may not be a carrier. A DNA test will look at multiple patterns. If you want, you can go for a DNA test. Being affected by thalassemia...  Read Full »

My son is a carrier of alpha thalassemia. Kindly guide us based on his blood test reports.

Query: Hi doctor, My son was diagnosed as a carrier of alpha thalassemia. I did the blood test report to check whether myself or his mother are the cause. Can you check the whole report for me and tell me what are the issues in this report?  Read Full »

Dr. Goswami Parth Rajendragiri

Answer: Hi, Welcome to I understand your concern. Your child is having alpha thalassemia carrier. So one of the parents might have an alpha thalassemia carrier. For that DNA analysis means molecular testing is needed. Through these analyses, gene deletion can be diagnosed. Based on your CBC ...  Read Full »

Is my friend's beta thalassemia screening test normal?

Query: Hello doctor,My cousin of 30 years old got tested for beta thalassemia screening test. He got the result as hemoglobin A2 is 2.8 %, hemoglobin F is 0.2 %, and hemoglobin C, D, and S are not detected. Is this normal or has any complications?Please guide.  Read Full »

Dr. Prakash H. M

Answer: Hi, Welcome to Based on your query, my opinion is as follows: The beta-thalassemia screening test appears to be normal. HbA2 levels (hemoglobin A2) are normally between 2 to 3.3% and HbF levels (fetal hemoglobin) are 0.1 to 1.2% for this age. Both are normal. The other hemoglobin typ...  Read Full »

My girlfriend and I are both thalassemia carriers with an alpha trait. Would it cause any problem if we plan to conceive?

Query: Hi doctor, I am a thalassemia carrier patient with an alpha trait, and my girlfriend also has the same thalassemia trait issue. Moreover recently I got diagnosed with neutropenia. My question is should I continue with the relationship with my girlfriend? Would it cause any problem, for our future ge...  Read Full »

Dr. Goswami Parth Rajendragiri

Answer: Hello, Welcome to I read your query and can understand your concern. In beta thalassemia condition, two minor couple marriage is not advisable. But in alpha thalassemia, the mechanism is somewhat complex because the alpha chain contains four gene alleles. So it has to be checked how man...  Read Full »

Please suggest a diet chart for thalassemia patient.

Query: Hi doctor, My brother is a thalassemia major subject. His age is 18 years and height is 5'4''. His hemoglobin is always maintained between 9 and 10 units. His weight is 38 now and drastically reducing. Nowadays he has been having headache and fever now and then. Sometimes he feels that his heartbeat...  Read Full »

Dr. Prakash H. M

Answer: Hi, Welcome to Based on your query regarding thalassemia, my opinion is as follows:1. Looking at a regular hemoglobin level of 9-10%, I would suggest you increase the levels. Maintaining at this level increases further erythropoiesis (production of red blood cells). Close to 12-13 g% ma...  Read Full »

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