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Published on Jan 04, 2019 and last reviewed on Sep 14, 2022   -  4 min read


Chronopharmacology is the science of optimizing drug effects concerning the biological rhythm. Read this article to know more.



Chronobiology is the science that studies the rhythm behind every biological process or function of living organisms. On the other hand, Chronopharmacology is the science that deals with the optimization of drug dose that promotes efficacy and minimizes the adverse effects by taking the medications in relation to the biological rhythm. In simple language, if we take our medication according to our body clock, the medicine can be more beneficial and cause minimal side effects. There are three divisions under chronopharmacology in which the chronotherapeutics approach accurately identifies when the patients are at the highest risk and in greatest need of therapy. This principle is used to treat diseases like cardiovascular diseases and many more.

Why Is Chronopharmacology Necessary?

How Is Chronopharmacology Classified?

Chronopharmacology is classified into three types. They are:

Chronopharmaceutics: It is a field of therapeutics specialized in designing and assessing a drug transport device that can release the drug at a rhythm based on the requirement for disease therapy.

Chronopharmacokinetics: This is a field that deals with rhythmic changes based on the drug bioavailability and its excretion. It works on drug adjustments in absorption, distribution, metabolism, and excretion. Several researchers worked in this field for better optimization of the drugs. One such research reports that cardiovascular drugs, non-steroidal anti-inflammatory drugs, anesthetics, anticancer drugs, anti-asthmatic drugs, and psychotropic drugs have better bioavailability when taken in the morning than in the evening.

Chronotherapeutics: It is the remedy approach carried out in vivo where the drug availability is timed to promote healing and minimize adverse effects. One technique to promote pharmacotherapy is the use of medicines at the times they are best tolerated. Prescribing the medicines at spaced durations in a day helps preserve a steady state coordinating with the diurnal variations. This approach is very effective in patients who suffer from cardiac, renal, and hepatic impairment, as the accumulation of medicines can cause toxicity and affect the organs.

What Is Chronopharamcotherapy?

Chronopharmacotherapy is a field that synchronizes the biological rhythm with drug management increasing therapeutic effects. In this process, the biological effects and rhythm characteristics are evaluated.

What Are the Advantages of Chronopharmacotherapy?

The advantages of chronopharmacotheray are as follows;

What Are the Disadvantages of Chronopharmacotherapy?

The disadvantages of chronopharmacotheray are as follows;

What Are the Ideal Characteristics of Chronopharmacotherapy?

What Are the Examples of Chronopharmacology?


Chronopharmacology paves the way for investigating each drug in regards to biological timing and its effects on a rhythmic pattern. It holds the promise of drug safety and enhances the treatment process for a particular disease. The primary goal is to promote the therapeutic effects and minimize the adverse effects without any modification of the drug function. The recently evolving discipline of chronopharmacology has opened several ways for managing higher procedures and special illnesses.

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Last reviewed at:
14 Sep 2022  -  4 min read




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