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How to Make Erectile Dysfunction Drugs Work Better?

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3 min read


The condition known as erectile dysfunction is characterized by persistent problems getting or keeping an erection. Read the article to learn more.

Written by

Dr. Aysha Anwar

Medically reviewed by

Dr. Ramchandra Lamba

Published At April 16, 2024
Reviewed AtApril 16, 2024


An erection that is not strong enough for sexual activity is known as erectile dysfunction or impotence. Periodically experiencing difficulties achieving an erection is not always a reason for alarm. However, if erectile dysfunction persists, it may lead to stress, undermine confidence, and exacerbate interpersonal issues. Difficulties getting or keeping an erection may also be a sign of an underlying medical condition that requires attention, in addition to increasing the risk of heart disease.

Do Erectile Dysfunction Pills Work?

There are four varieties of erectile dysfunction tablets on the market, including Sildenafil and Tadalafil. Erectile dysfunction medicines are compared in effectiveness, pricing, side effects, and more. One should take every precaution to ensure that any prescription medication taken for erectile dysfunction is working as intended. Spend a few minutes learning how to maximize the benefits of a prescription. The medications that are sold in the US include Vardenafil, Tadalafil, and Avanafil. These all enhance the penis's blood supply. When coupled with sexual stimulation, the medications can result in an erection firm enough to start and finish a sexual encounter. Levitra is a fast-dissolving medicine that patients easily can take under their tongue.

When Might It Not Be Safe to Take Medications Orally?

Consult the medical team before starting any erectile dysfunction medication. It is possible that oral ED medications could be hazardous or ineffective if taken with any of the following:

  1. Nitrate-Containing Medications: These are frequently used for angina, a type of chest pain. Nitroglycerin, Isosorbide mononitrate, and Isosorbide Dinitrate are a few examples of Nitrates.

  2. Alpha-Blockers: These are frequently used for male pattern baldness and enlarged prostates. These consist of Finasteride and Dutasteride.

  3. Medications: That Inhibit the Cyp3a4 Enzyme: Ritonavir, Ketoconazole, and Itraconazole.

Additionally, using erectile dysfunction medication orally may not be safe or effective if one has the following conditions:

  1. High blood pressure (hypertension) or shallow blood pressure (hypotension).

  2. Having extreme liver damage.

  3. Suffering from kidney disease.

  4. Recent issues with the heart or blood vessels (a major cardiac rhythm abnormality, heart attack, or stroke within the last six months.)

  5. Retinitis pigmentosa (a genetic condition that damages the retina in the eyes).

What Are the Side Effects of Oral Erectile Dysfunction Medications?

Oral erectile dysfunction medications frequently have minor side effects. Typically, they consist of the following.

  • Skin washing.

  • Ache.

  • Upset stomach.

  • Visual abnormalities like a blue tint, light sensitivity, blurry vision, congestion, or runny nose.

  • Back discomfort.

  • Feeling lightheaded.

More severe side effects are uncommon and can include:

  • Loss of Eyesight or Hearing: After taking one of these medications, some persons experience an abrupt loss of some of their vision or hearing. However, it is unclear if the patients' pre-existing medical issues or the medication caused these adverse effects. If a patient uses oral medication and experiences a sudden loss of vision or hearing, get medical attention immediately.

  • An Erection That Refuses to Go Away: Known as priapism, this uncommon ailment may cause discomfort. To avoid harm to the penis, the patient must seek treatment for it as soon as feasible. Contact the care team as quickly as possible if an erection lasts more than four hours.

Only one in ten men between the ages of 40 and 70 report being completely unable to get an erection, but almost half of them have erectile dysfunction to some extent. After using an erectile dysfunction prescription, over 70 percent of otherwise healthy men get an erection strong enough to start a sexual relationship.

How Potent Are Erectile Dysfunction Medications?

About 70 percent of men who take erectile dysfunction medications get an erection firm enough for sexual activity. However, each person experiences somewhat different outcomes. A person who has had cardiovascular illness, diabetes, or prostate surgery and has harmed his arteries or nerves will not react to erectile dysfunction medications as powerfully. The duration of the medications' effects varies from 15 to 60 minutes. If patients take medicine after eating, their absorption is blocked and will not work. Some males lament the lack of efficacy of the drug. Sometimes, it is because they misused it. The most common misperception is that erections may be turned on and off with these medications. But when there is no sexual excitement, the drugs do not work as well.

When Do Erectile Dysfunction Medications Expire?

The bodies of the erectile dysfunction medications degrade them at various speeds. When using greater doses of Sildenafil, the duration of action can vary from four hours to over a day. Every dosage needs to be adequate to supply the whole sexual cycle—from climax to erection.

What Are the Adverse Effects of Erectile Dysfunction Medications?

From most to least common, headache, flushing, upset stomach, nasal congestion, visual issues, diarrhea, dizziness, and rash are the most frequent adverse effects of ED medication. There are some essential things to remember:

  1. While many men with erectile dysfunction have found success with Vardenafil and Tadanafil, these medications do not work well in patients who have had prostatectomy surgery (performed to treat various prostate-related problems like prostate cancer) unless a nerve-sparing technique is employed.

  2. It is necessary to avoid using these drugs with nitrate-containing ones, such as Deponit, Nitrostat, Nitro-Bid, Nitro-Dur, Isordil and Ismo, and nitroglycerin.


In conclusion, the erectile function of erectile dysfunction medication is enhanced, and it is generally well tolerated. Although Sildenafil is more effective than a placebo in every subgroup examined, treatment response appears to differ throughout patient subgroups—exercise, particularly moderate-to-intense aerobic activity, to improve erectile dysfunction. Regular exercise, even if it is not as intense, may help lower the risk of erectile dysfunction. Raising the activity level may also help to reduce the risk even more.

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Dr. Ramchandra Lamba
Dr. Ramchandra Lamba



erectile dysfunction
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