Novel brain stimulation techniques have developed in the field of psychiatry. This article focuses on the newer modalities of brain stimulation in the treatment of complex neuropsychiatric disorders.
Brain stimulation technique is a broad term that encircles a set of techniques that are used to stimulate brain cells. After having highly effective psychotropics and psychotherapy in their treatment armamentarium, psychiatrists are now entering into the field of interventional psychiatry. However, these therapeutic interventions are non-invasive; that is, there is no surgical incision needed in order to administer these interventions. The only exceptions to this are vagal nerve stimulation (VNS) and deep brain stimulation (DBS).
The non-invasiveness of these procedures provides a huge benefit to the patients. While invasive surgical procedures are filled with numerous risks, and so these brain stimulation therapies are very safe. These techniques primarily employ implants, electricity, or magnets to treat a moderator of complex neuropsychiatric conditions.
Among the currently available brain stimulation techniques, electroconvulsive therapy - ECT is the oldest and the most researched form. The other techniques include,
Repetitive transcranial magnetic stimulation (rTMS).
Magnetic seizure therapy (MST).
Transcranial direct current stimulation (tDCS).
Vagus nerve stimulation (VNS).
Deep brain stimulation (DBS).
Focal electrically administered seizure therapy (FEAST).
Electroconvulsive therapy (ECT) was developed by Ugo Cerletti and Lucio Bini in 1938. Unfortunately, ECT (electroconvulsive therapy) has been portrayed in poor light in the media.
On the contrary, it is a life-saving technique and is highly efficacious. No pain is felt during the procedure as the patient is anesthetized.
Most commonly, ECT is used in the treatment of intractable mood disorders. These include severe depression with psychotic symptoms and treatment-resistant depression.
ECT is the standard gold treatment in patients harboring suicidal tendencies. Suicidal ideas abate after three to four treatments, and the patient reaches his or her pre-morbid self after about six treatments.
ECT (electroconvulsive therapy) is also used in the treatment of bipolar disorder and treatment-resistant schizophrenia. It should be noted that ECT is particularly effective against the positive symptoms of schizophrenia.
1) Repetitive Transcranial Magnetic Stimulation (rTMS):
This modality differs from ECT and in that it employs a magnet instead of an electric current to stimulate the brain. It was approved for the treatment of the major depressive disorder (MDD) in 2008. Recent data indicate the good efficacy of this modality in tackling depressive disorders, treatment-resistant auditory hallucinations of schizophrenia, and negative symptoms of schizophrenia.
It targets a specific brain area that is predetermined before administration. A typical session lasts anywhere between 30 to 60 minutes and does not require anesthesia. The procedure involves the placement of an electromagnetic coil against the forehead. This coil is held near the area of the brain that is thought to regulate mood and emotions. The generated magnetic pulse traverses across the skull and results in stimulating a specific brain area. The pulsed magnetic wave can traverse only as far as 2 inches into the brain. This prevents damage to other critical brain areas.
Some common but negligible side effects include scalp discomfort and headache. It is imperative to rule out seizure disorder before administering rTMS, as in some predisposed individuals, there exists a theoretical possibility of precipitating a seizure. However, it is a very safe and highly efficacious procedure.
2) Magnetic Seizure Therapy (MST):
This is an amalgamation of ECT and rTMS as it draws from the concepts used in the aforementioned procedures. Like ECT, it produces a short-lasting seizure, and like rTMS, it uses a magnetic pulse to produce this. It differs from ECT in that it does not use electricity to generate a seizure. The patient is anesthetized and is unaware of the seizure. Recent data confirm its efficacy in the treatment of mood disorders. The advantages of MST over ECT include a shorter-lasting seizure and fewer memory side effects.
3) Vagus Nerve Stimulation (VNS):
In this modality, an implanted device beneath the skin generates electrical pulses through the left vagus nerve. This nerve transmits signals from the brain to a host of other organs like the heart, lungs, and other brain areas that regulate core functions like mood and sleep. This modality of treatment was initially devised for the treatment of epilepsy. It soon became clear that it was indispensable in the treatment of mood disorders, especially depression. VNS critically modulates the levels of brain chemicals called neurotransmitters. These include serotonin, norepinephrine, GABA, and glutamate. These brain chemicals play a crucial role in mood regulation. The pulses generated by the device last for 30 seconds, and they are generated about every 3 to 5 minutes. The pulse generator is a battery-assisted device that has a lifespan of about 10 years, after which it should be replaced. Once these pulses reach the left vagus nerve, signals are delivered to brain areas controlling mood resulting in modulation and regulation of the mood state.
Some adverse side effects include infection of the implanted device, cough, sore throat, hoarseness of voice, tingling, and discomfort. However, these occur in a minor proportion of individuals and are handled on a symptomatic basis. Data indicate that VNS is a safe and effective procedure.
4) Deep Brain Stimulation (DBS):
This is an invasive procedure and requires brain surgery. The head is shaved and attached to a sturdy frame with the help of screws. This is done to keep the head stable during the procedure. The brain is scanned using magnetic resonance imaging (MRI). The scanned images are used during the surgery, which guides the placement of the electrode in a specific brain area. The patient is awake during the procedure but feels no pain as the head is numbed with local anesthesia.
During the procedure, two holes are drilled into the head. A slender tube is threaded into the brain to place electrodes on a specific brain part. In case of depression, these electrodes are placed in area 25 of the brain, which has been found to be hyperactive in mood disorders. The cortical-striatal-thalamic tract is targeted in case of obsessive-compulsive disorder, and the subthalamic nucleus is targeted in case of Parkinson's disease. Throughout the procedure, the patient guides the placement of these electrodes by providing feedback on how he or she subjectively feels about his or her symptoms following the electrode placement. The exact site is determined when the patient tells that his or her symptoms have abated maximally in one particular position. Following this, the patient is put under general anesthesia, and the electrodes are attached to wires that run from the head to the chest. In the chest, a pair of the battery-operated device is implanted, which generates electrical pulses continuously to the electrodes placed in the brain.
DBS carries with it the risks that are associated with any other invasive brain surgery. These include bleeding, infection, altered mental state, lightheadedness, and sleep abnormalities. However, if done by an experienced hand, the procedure is quite safe.
In summary, these novel modalities of treatment in psychiatry hold a great promise for the future. It is imperative to build awareness and educate the public about the availability of these therapeutic modalities. All these techniques fall under the rubric of interventional psychiatry, which is the bright new face of a specialty that has dedicated itself to alleviate the suffering of mankind.
Last reviewed at:
14 Sep 2021 - 5 min read
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