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Psychedelic-Assisted Therapy for Mental Health - A Comprehensive Review

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Psychedelic-assisted psychotherapy uses psychedelic drugs to treat certain mental disorders like anxiety. Read below to learn more.

Written by

Dr. Neha Rani

Medically reviewed by

Dr. Vishal Anilkumar Gandhi

Published At March 18, 2024
Reviewed AtMarch 26, 2024

Introduction

The prevalence of mental illnesses is rising, yet the rate at which new psychiatric drugs are created is slower than in the past. The lack of advancement in the understanding and diagnosis of mental diseases is giving rise to a heated dispute. Psychedelic-assisted psychotherapy (PAP) is a novel therapeutic modality that entails the judicious use of substances such as MDMA (3,4-methylenedioxy-N-methamphetamine - Ecstasy), Ketamine, LSD (lysergic acid diethylamide), Psilocybin, and Ibogaine during therapy sessions. Research indicates that this may be safe and beneficial even for ailments that have not responded well to previous therapies. PAP challenges one's understanding of and approach to diagnosing mental health issues in addition to providing novel solutions. It considers factors such as past experiences, trauma, and the possible advantages of altered states of consciousness beyond what one typically encounters.

What Is Psychedelic-Assisted Psychotherapy (PAP)?

Psychotherapy that involves the use of psychedelic substances during therapy sessions is referred to as psychedelic-assisted psychotherapy (PAP) or psychedelic therapy.

Together with talking to a therapist, psychedelic therapy involves the use of substances. Some psychedelic substances, such as magic mushrooms (Psilocybin), DMT, peyote, ayahuasca, and Ibogaine, are derived from plants, while synthetic compounds, like Ketamine, MDMA, and LSD, are being investigated for their potential therapeutic uses.

Due to the increasing legalization of some psychedelic drugs, the rise in mental health problems, and the decreased emphasis on the development of new psychiatric pharmaceuticals, psychedelic therapy is becoming more and more popular.

What Are Psychedelics?

Psychedelics are drugs that cause alterations in perception, which frequently results in a distortion of reality in how people see, hear, and feel things. They are classified as entactogens, dissociatives, and psychedelics.

  • Psychedelics: This group includes substances including Psilocybin, Mescaline, DMT, LSD, and Peyote. They can sometimes elicit emotions of joy or euphoria and have an impact on self-analysis, sensory perception, and temporal perception.

  • Entactogens: This group includes, for example, MDMA. Users of these medications report increased emotional openness and empathy.

  • Dissociatives: The drug Ketamine is a dissociative, which means that it can cause sensations of disassociation from the body or environment.

Overall, psychedelics have the potential to cause altered perception, increased self-awareness, altered perception of time, and, occasionally, mystical or happy emotional states.

How Safe Are Psychedelic Therapies, and What Are the Risks?

Psychedelic substances can bring advantages as well as concerns. Due to their susceptibility to abuse and safety issues, they are legally limited and frequently viewed as having little medical benefit. In particular, those with a history of mental illness may experience psychotic episodes or permanent perceptual abnormalities as a result of them. They frequently have a connection to hallucinations. However, the hazards can be reduced when administered under medical supervision in controlled conditions. The majority of adverse effects are temporary, such as elevated heart rate or anxiety.

Strict guidelines have been established by researchers to reduce dangers during psychedelic treatment sessions. Meetings take place in secure, comfortable settings with licensed therapists present after patients have undergone a thorough screening process. It is suggested that patients use the time to think back on the events while enjoying soothing music. Follow-up meetings facilitate the integration of therapeutic insights.

These procedures will keep getting better as research goes on, making psychedelic therapy much more secure and efficient.

What Are the Indications for Psychedelic-Assisted Therapy?

Psilocybin and LSD have been shown to have the potential to ease anxiety, particularly in patients nearing the end of their lives. Meanwhile, MDMA is being investigated for its ability to alleviate social anxiety in individuals with autism (a neurological disorder that impacts a person's ability to learn, behave, connect with others, and communicate). Ayahuasca has the potential to decrease substance use in some societies, which has sparked study efforts worldwide. Recent studies on addiction treatment suggest that Psilocybin can help with addictions to alcohol and tobacco. Regarding PTSD (post-traumatic stress disorder), chronic patients respond well to MDMA-assisted therapy in terms of symptom reduction, and long-term improvements are seen even years following treatment. These results are encouraging, but more study is necessary before they may be widely used in clinical practice.

How to Enhance Access to Psychedelic Therapy With Limited Mental Health Workers?

Clinical research has shown that psychedelic-assisted therapy requires a substantial time commitment and specialized care. However, many people who could benefit from such treatment are unable to obtain it due to the present lack of mental health professionals in the United States. Expanding the number of therapists, psychiatrists, and counselors via extensive training programs is necessary to improve accessibility. Furthermore, continuing mental health practitioners ought to be trained in the safe and efficient administration of this therapy.

Since more and more states have legalized psychedelics, more people are probably going to ask their doctors about them. Therefore, healthcare professionals must possess the knowledge and tools necessary to help their patients make wise decisions about psychedelic therapy.

What Difficulties Are Associated With Conducting Research on Psychedelic Drugs?

Psychedelic-assisted psychotherapy (PAP) involves testing psychedelic medications in conjunction with treatment. In this case, a qualified therapist helps the patient work through their drug-related experiences.

Researchers employ a study design known as a randomized controlled trial to determine whether a medicine is effective. Participants were divided into two groups; one receives medication therapy, while the other (referred to as the control group) does not. To assess the efficacy of the real medication compared to a placebo, the control group may get phony therapy.

However, testing psychedelic therapies can be challenging because it is frequently evident who received the real medication and who did not. This information can skew the results and reduce their validity. In certain studies, the treatment assignment was disclosed to both the patients and the researchers under the term "open-label." This may make it more difficult to accept the results.

Conclusion

The study of psychedelic chemicals, which have long been utilized in rituals and treatment, is attracting the attention of scientists. Given an upsurge in addiction and mental illness, government leaders ought to be aware of these novel treatments. It is now difficult to conduct adequate studies on psychedelic drugs due to restrictions and popular misconceptions. Psychedelics have a great deal of potential to address mental health issues. However, more study is needed to ensure the safety of those wishing to use psychedelics for mental health treatment as well as to improve the best practices for psychedelic-assisted therapy. It is advisable that states and localities carefully evaluate measures to guarantee that people have access to adequate mental health support as they move forward with the decriminalization or legalization of psychedelic chemicals. Enabling responsible use and access to therapeutic resources may entail putting in place rules, policies, and support networks.

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Dr. Vishal Anilkumar Gandhi
Dr. Vishal Anilkumar Gandhi

Psychiatry

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