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Harmful Effects of Nitrogen Oxides - Causes, Symptom, and Treatment

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Nitric oxide and nitrogen dioxide are two of the most important nitrogen oxides that have harmful effects on humans. Read to know more.

Medically reviewed by

Dr. Arpit Varshney

Published At October 30, 2023
Reviewed AtOctober 30, 2023

Introduction

It is not unusual to see people going through a crowded city with masks covering their faces. Even a hazy brown haze in the sky can come to mind. These depictions of city life are inspired by environmental dangers like acid rain and smog, which are worldwide present due to industrial waste generation over the past century or so. Nitric oxide gas (NO), which oxidizes to generate the gaseous pollutant nitrogen dioxide, is the specific waste product in question. These are referred to as NOx or nitrogen oxides, as a group. Numerous negative health implications of nitrogen oxides become apparent when their concentration is high enough to cause smog and acid rain, and they vary from an increase in the incidence of respiratory diseases like asthma to agricultural and vegetation inhibition.

What Are Nitrogen Oxides?

A combination of gasses made of nitrogen and oxygen is known as nitrogen oxides. Nitric oxide and nitrogen dioxide are two of the prominent toxicologically relevant nitrogen oxides; they are both nonflammable and appear colorless to brown at room temperature. At room temperature, nitric oxide is a bright, sweet-smelling gas, but nitrogen dioxide has a strong, harsh odor, is a liquid, and becomes a reddish-brown gas above 70 degrees Fahrenheit.

When coal, oil, or natural gas are burned, as well as during operations like arc welding, electroplating, engraving, and dynamite blasting, nitrogen oxides are discharged into the air. They can also be made in large quantities commercially by mixing nitric acid with cellulose or metals. Nitric acid, lacquers, colors, and other compounds are made using nitrogen oxides. Additionally, the nitration of organic molecules, the production of explosives, and rocket fuel all need nitrogen oxides.

Nitrogen oxides, which are distinct from the nitrous oxide (N2O) utilized in dental operations, are created both naturally and through the burning of fossil fuels like coal and gasoline. Additionally, it results from smoking cigarettes. Due to its single unpaired electron, nitric oxide (NO) quickly oxidizes when combined with ozone (O3) to produce nitrogen dioxide (NO2) and oxygen (O2). NOx is an odorless, colorless gas that is corrosive and acidic. Its function in contributing to a variety of health issues is due to its high reactivity.

When Nitrogen Oxides Are Released Into the Environment, What Happens to Them?

  • By reacting with other compounds that are frequently present in the air, nitrogen oxides are swiftly decomposed in the environment.

  • Nitric acid, a key component of acid rain, is generated as a result of the reaction between nitrogen dioxide and molecules from sunlight.

  • Additionally, when sunshine and nitrogen dioxide combine, ozone and smog conditions are created in the air individuals breathe.

  • Nitrogen oxides may partially evaporate from water, but most of them will react with it to produce nitric acid. Small quantities of nitrogen oxides may evaporate into the air after being released onto the soil. But the majority of it will be changed into nitric acid or other substances.

  • No accumulation of nitrogen oxides occurs in the food chain.

What Impact Might Nitrous Oxides Have on a Person’s Health?

  • Low concentrations of nitrogen oxides in the air can irritate the eyes, nose, throat, and lungs, making one cough and possibly making one feel exhausted, nausea, and fatigued.

  • Low amounts of exposure may result in fluid buildup in the lungs one or two days after exposure. High nitrogen oxide concentrations in the air can result in fast burning, spasms, and swelling of the throat and upper respiratory tract tissues, decreased oxygenation of body tissues, an accumulation of fluid in the lungs, and even death.

  • High concentrations of nitrogen dioxide liquid or nitrogen oxide gasses would probably cause severe burns if they came into contact with the skin or eyes.

  • It is not known if nitrogen oxide exposure will have an impact on human reproduction.

How Probable Is It That Nitrogen Oxides Cause Cancer?

Various international health and safety have not classified nitrogen oxides as potentially carcinogenic.

How Might One Come Into Contact With Nitrogen Oxides?

Most people's exposure to nitrogen oxides comes through breathing in air. Residents of locations with high levels of motor vehicle use or those who reside close to combustion sources like coal-burning power plants may be more exposed to nitrogen oxides. Compared to homes without these appliances, households that burn a lot of wood, use kerosene heaters or utilize gas stoves typically have higher nitrogen oxide levels. People who smoke or breathe in secondhand smoke may be exposed to nitrogen oxides because tobacco smoke contains nitric oxide and nitrogen dioxide.

Workers who weld metals, those who work in factories that make nitric acid or specific explosives like trinitrotoluene (TNT) and dynamite, or both, may breathe in nitrogen oxides while at work.

What Impact Do Nitrogen Oxides Have on Children?

Nitrogen oxide exposure would likely have the same effects on children as it does on adults. However, it is unknown if kids are more or less susceptible to nitrogen oxides than adults.

Nitrogen oxide exposure in pregnant animals has harmful effects on growing fetuses. The genetic makeup of animal cells has also been altered by nitrogen oxides. However, it is unknown whether nitrogen oxide exposure may have an impact on human development.

How Can Families Lessen Their Chances of Being Exposed to Nitrogen Oxides?

By periodically letting in some fresh outdoor air, families that use indoor gas stoves, smoke, or use space heaters indoors can reduce their exposure to nitrogen oxides. Families on farms should not let kids play close to silos that hold silage.

Is It Possible to Prove Whether an Individual Has Been Exposed to Nitrogen Oxides Through a Medical Test?

The doctor generally is not helped by specific tests for nitrogen oxides in blood or urine. If a serious exposure has happened, blood and urine tests, as well as other examinations, may reveal whether the respiratory airways have been harmed. Some of these tests might be performed at the doctor's office, while others might need to be done in a clinic or hospital with specialized equipment.

Conclusion:

Nitrogen oxides have hazardous effects on human health and the environment; hence air quality monitoring is a necessary step. Testing the air can be a step towards curbing the harmful effects of nitrogen oxides. Offices and households should keep watch on their air quality to facilitate better health.

Dr. Arpit Varshney
Dr. Arpit Varshney

General Medicine

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