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Brachydactyly - Types, Causes, and Treatment

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Brachydactyly is an inherited condition leading to short limbs. This article explains this condition in detail.

Medically reviewed byDr. Anuj Nigam

Published At September 20, 2022
Reviewed AtJune 21, 2024

Introduction:

Brachydactyly is a clinical condition characterized by small fingers and toes due to rarely observed short bones. It is an inherited condition and thus, cannot be prevented. Most people experiencing this condition do not have any serious problems or limitations. However, some other medical conditions may occur along with brachydactyly and cause inconvenience, and thus, should be treated effectively.

There are various types of brachydactyly, depending on the kind of bone that is shortened. This condition can also indicate the presence of some other genetic disorder.

What Are the Symptoms of Brachydactyly?

The signs of this condition can usually be witnessed during birth, but they become more evident during growth and development due to changes in physical proportion. The most common symptom of brachydactyly is shorter fingers, toes, or both. The affected person does not feel discomfort or pain unless they have other associated conditions. The shortened fingers and toes can make it challenging to have a firmer grip, and the person may have difficulty walking if the condition is severe in the feet. However, these discomforts occur occasionally.

How Is Brachydactyly Caused?

Brachydactyly is an inherited condition. Hence, the cause is attributed to genetics. It is an autosomal dominant condition. This indicates that only one parent with the concerned gene is required to affect the next generation. The reason for such genes can be two mutations in a single gene. Another cause can be the intake of certain medications by the mother during the pregnancy. Also, any changes in the hand and feet blood circulation, especially in babies, may cause this. Some other genetic conditions associated with syndromes that may cause this condition are Down syndrome (chromosome 21 disorder causing intellectual and developmental delays) and Cushing’s syndrome (when the body produces excess cortisol hormone for prolonged duration).

What Are the Types of Brachydactyly?

The various types of brachydactyly are divided based on the affected bones and digits. Following are the five types of brachydactyly:

Type A - This type of brachydactyly is characterized by the shortening of the middle phalanges. This can be further classified based on finger types as the following:

  • Type A1: Shortened middle phalanges of all the fingers.

  • Type A2: Shortening the index finger; sometimes, the little finger can be shortened.

  • Type A3: Only the little finger is affected.

Type B -This type of brachydactyly affects the ends of the index and little fingers. The proximal bone on each finger is either shortened or absent. The absence of nails is also observed. A similar scenario is observed in toes. The thumb bones can be flattened or split.

Type C - It is unusual and usually affects the index, middle, and little fingers. In this type, the middle phalanges are affected, but the ring finger mostly remains unaffected and appears to be the longest finger on the hand.

Type D - This type of brachydactyly is commonly occurring and affects the thumbs alone. Shortening of the end bones of the thumbs can be seen, but all the fingers appear normal.

Type E - This brachydactyly is a rare type and is characterized by the presence of shortened metacarpals and metatarsals. These bones are the third and fourth from the end of the digits in the hands and feet. This leads to shorter appearing hands and feet.

How Does Brachydactyly Affect One's Health?

The condition is rarely known to affect the person’s overall health. It may cause difficulty in performing tasks. However, Brachydactyly can only affect one’s health if it occurs along with some other medical condition. In such cases, it also guides the healthcare professionals to identify the actual cause of the condition, for example, in young children, the doctor can diagnose Cushing’s syndrome in brachydactyly cases. This indicates that the child’s health is not affected by Brachydactyly rather some other medical condition is deteriorating their health.

How Is Brachydactyly Diagnosed?

When one visits the physician, they will be asked certain questions about the types of signs and symptoms they are facing, family history, and personal history. Following this, a careful examination of the hands and feet will be done to diagnose brachydactyly. X-rays can also be utilized to visualize the shortened bones and to diagnose the type of brachydactyly. In mild cases, an X-ray alone can help in diagnosing the condition.

A full-body skeletal examination is done to check if brachydactyly is part of a syndrome or not. Also, this helps in visualizing whether other bones are normal in the body or not, thus the presence of the syndrome can be assessed. Genetic testing may also be required to determine the presence of the syndrome.

How Can Brachydactyly Be Treated?

Most cases of brachydactyly do not require any treatment. If the condition is not associated with any other syndrome, the person should be healthy and will not have any medical concerns related to the hands and feet.

Rarely, brachydactyly can be severe enough to cause problems with performing various functions. The affected person may have issues with gripping things or walking normally. In such cases, physical therapy can be given. Physical therapy can lead to an improvement in the range of motion and both strength and functions of the affected areas can be enhanced.

Another option is surgery. However, this method is chosen in rare and severe cases. Plastic surgery can be done for cosmetic purposes, or in unusual cases, it can help in improving the functions. Most of the patients requiring surgery usually have an associated syndrome or condition. The surgery chosen may include an osteotomy, which means cutting and shaping the bone. This can help in the gradual lengthening of the short fingers.

What Are the Risk Factors?

The risk factors for this condition are as follows:

1. Brachydactyly is typically an inherited or genetic condition. Hence, if a family member has brachydactyly, the risk of developing this condition is much higher.

2. If the child is born with Down syndrome, the risk for brachydactyly is increased.

3. Women have an increased risk of developing brachydactyly than men. This can be partially linked to the fact that women are more likely to experience the complete expression of the trait than men. Hence, this condition is more observable in females.

Are There Any Complications Associated With Brachydactyly?

Most people with brachydactyly do not experience any major complications that are known to interfere with their daily activities. In a few cases, if the brachydactyly is severe, it can limit the functions of the hands or may cause difficulty in walking. Surgery and physical therapy can prove to be useful in such cases.

Conclusion:

Brachydactyly is a clinical condition characterized by shortened limbs and does not cause any major effects in most cases. Also, it is a genetic condition, that cannot be prevented. Therefore, one must consult the healthcare provider for better understanding and also get appropriate treatment for any underlying medical condition affecting one’s health other than brachydactyly.

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Frequently Asked Questions

Brachydactyly is a congenital disorder where a person has abnormal fingers and toes; these defects are present at birth. The condition is noticed immediately on birth if the child is born as the condition has many stillbirths.
Brachydactyly is a genetic disorder with an autosomal dominant type of inheritance; this condition is commonly seen amongst royal families and thus is prevalent in parents from consanguineous marriages.
Brachydactyly is known for abnormal toes and fingers; similarly, patients with this disorder have characteristic short and stud thumbs, also called royal thumb brachydactyly, as it is commonly seen among royal families.
Brachydactyly is an autosomal dominant disorder. Therefore the chances of every offspring inheriting it are about 50 ℅ , irrespective of the sex of the child. As every person in the family is affected, it is unlikely that a generation can be unaffected.
Brachydactyly is of various types like type A, type D, etc.; the condition's occurrence is rare. Type A3 and D are most prevalent and affect 2 % of the population worldwide.
Brachydactyly is a genetic disorder inherited from parents as an autosomal dominant trait. Studies so far have reported that the condition runs in the family.
Short limbs are characteristically found in many genetic disorders like achondroplasia, short limb dwarfism, brachydactyly, etc.
Brachydactyly type B is an autosomal dominant genetic condition characterized by incomplete development or absence of the distal phalanges of fingers, toes, and nails. In addition to this, hypoplasia, a short length of the middle phalanges, a fusion of the joints, broad thumbs, and webbed fingers are also seen. The feet, in these cases, are less severely affected than the hands. Brachydactyly type B is of two types, type 1, which results from genetic alterations in the ROR2 gene, and type 2, due to a defective NOG gene.
Brachydactyly type C is a rare genetic disorder caused by a defect in the GDF5 gene. This condition is characterized by short limb bones, especially in the index, middle and little fingers. However, the ring finger bones are generally normal, with other symptoms like curvature at the end of long bones.
Brachydactyly is a congenital condition that leads to various developmental abnormalities; therefore, brachydactyly can also be called a genetic disorder.
Brachydactyly type E is a generic disorder with characteristic symptoms, including short limbs, stunted growth, and hyper flexibility of the joints.
Brachydactyly is a rare genetic disorder, categorized into various types based on the mutation.  Amongst all types of brachydactyly, type D is the most commonly occurring brachydactyly, whereas other types, like type E, are rare amongst the cases of brachydactyly.
Brachydactyly is a genetic condition diagnosed at birth, and it is considered to be caused by a gene mutation that affects bone growth and development. The gene involved is considered the GDF5 gene; this gene's defect or mutation results in this rare genetic condition.
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