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Fractional Flow Reserve: An Overview

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Fractional flow reserve is a procedure that helps determine the severity of narrowing in the arteries of the heart (coronary artery). Read below to know more.

Written by

Dr. Arjun Singh

Medically reviewed by

Dr. Muhammad Zohaib Siddiq

Published At November 22, 2023
Reviewed AtNovember 22, 2023

Introduction:

A fractional inflow reserve assessment compares the blood inflow on either side of a blockage in the arteria coronaria (coronary artery - main artery of the heart). It indicates how severe the narrowing (stenosis) is in the artery. However, the patient will need medical treatment or cardiac angioplasty (a procedure to widen the blocked artery). The physician decides the treatment based on the test results.

What Is a Fractional Inflow Reserve?

Fractional inflow reserve (FFR) is a minimally invasive procedure to work out how bad the narrowing (stenosis) is in the coronary vasculature (vessels). The physician does this by checking the vital signs and inflow in the coronary vasculature. The physician compares the veritably different possible blood inflow with and without a blockage. Physicians do the fractional inflow reserve test as a part of cardiac catheterization (insertion of a tube or catheter in the heart) of the heart’s left side or during a coronary angiogram. The results help them decide which treatment they would like.

When Would Fractional Inflow Reserves be Required?

This test may be required when the healthcare physician is deciding the mode of treatment. The mode of treatment can be angioplasty or a stent in one of the coronary vasculature. They carry blood containing oxygen to the cardiac muscle. Physicians use this cost-effective, simple test when imaging shows 50 percent to 70 percent periphery narrowing (stenosis). In some cases, physicians may check fractional inflow reserves in people with over 90 percent narrowings. This test is not required if the narrowing is lower than 30 percent or over 70 percent. This is frequently because it is formerly clear that angioplasty is not required if the patient has minimum stenosis unless the number is high. After the implementation of angioplasty and a stent into the arteria coronaria, fractional inflow reserve can help prognosticate whether the patient will have a serious heart issue or not.

What Are the Downsides of a Fractional Inflow Reserve Assessment?

False results are one of the most common downsides of a fractional inflow reserve assessment. For example, if the patient has been prescribed some medication, or the patient fails to take the same, or is taking any additional medication, the results might appear false. This implies that the test result might show a blockage even if there is none.

What Are IFR and FFR?

Both are tests that determine how severe the narrowing is in coronary vasculature. Instant surge-free rate (IFR) does not use a medicine like Adenosine to widen the blood vessels for the test, but FFR does. A cardiologist performs a fractional inflow reserve test.

How Does a Fractional Inflow Reserve Test Work?

The physician uses an instrument to bear vital sign readings on each side of a blockage inside the arteria coronaria (coronary artery). The computational device uses these readings to calculate the fractional inflow reserve.

How Can a Patient Brace Against the Coronary Fractional Inflow Reserve Assessment?

The physician may ask to take certain drugs, especially blood thinners, several days before the test. Also, do not eat or drink anything after the night before the procedure. After the administration of anesthesia, someone is required to drive the patient back home.

What to Anticipate on the Date of the Fractional Inflow Reserve Assessment?

The test might conclude within an hour. Still, if the physician decides to try to do an angioplasty and put in a stent, those will take over time. Permittance to medication and recovery time is also needed. Ask the physician about the entire time anticipated to be spent at the sanitarium.

What to Anticipate During The Fractional Inflow Reserve Test?

The healthcare physician will-

  • Fit an area anesthetic into the skin.

  • Fit a needle in the arm, neck, or groin.

  • Use the needle to string a catheter into the roadway.

  • Advance the catheter through the vasculature to prompt the aorta and the coronary vasculature, which begins with the aorta. Fluoroscopy(X-ray) helps the physician see where the catheter goes.

  • Fit liquid discrepancy media through the catheter and into the coronary vasculature to make them easier to ascertain.

  • Check for blockages in the coronary vasculature.

  • Use an ultrasound device on the catheter to feel the blood inflow.

  • Offer Heparin and Nitroglycerin before moving a pressure line into the narrow area.

  • Use the catheter’s pressure detectors to see the pressure on either side of the narrow part of the arteria coronaria. For an accurate dimension, blood inflow is checked when at its loftiest. They give a drug (Adenosine or Papaverine) to extend the blood inflow.

  • Perform an angioplasty and stent placement if required.

  • Check the FFR again after completing the angioplasty and fixing a stent.

  • Remove the catheter and put pressure on the access point.

What Is Anticipated After the Fractional Inflow Reserve Procedure?

People do not have tons of discomfort and rarely have complications from an FFR test. The majority of people can head home a couple of hours after their FFR procedure. Still, if the patient gets an angioplasty and a stent, will get to stay overnight in the sanitarium.

What Are the Negative Effects of a Coronary Fractional Inflow Reserve Procedure?

A feeling of pain and/ or briefness of breath a few nanoseconds after the healthcare physician administers adenosine through the IV or directly into the arteria coronaria (coronary artery). This response is normal and helps the physician know that it is time to bear the readings because the blood inflow is at its peak. Papaverine can get an abnormal cardiac level in 1 of the cases. Typically, this only lasts a brief time. Because one gets a fractional inflow reserve procedure during cardiac catheterization, one accepts the threats of that procedure also.

How Does One Calculate Fractional Inflow Reserve?

To make a fractional inflow reserve computation, divide the pressure on the contrary side (distal) of the blockage by the pressure closer (proximal) to the blockage. The physician collects these fractional inflow reserve measures during cardiac catheterization.

What Kind of Results Does One Get and What Do the Results Mean?

A traditional result ranges from 0.94 to 1. Any number below means some kind of treatment is required because the blood inflow is a lower amount than what it should be. For example, if the FFR is 0.75, the narrow section of the arteria coronaria (coronary artery) is causing a 25 percent drop in pressure. However, angioplasty or a stent is not needed. If the fractional inflow reserve shows that the arteria coronaria blockage is not bad, drugs are prescribed.

When Is the Patient Informed About the Results of the Fractional Inflow Reserve Assessment?

When the healthcare physician takes the pressure measures, they will see the pressure figures and FFR on their computational devices. The patient is informed about what the FFR is during or after the procedure.

When Should One Call the Physician?

After the fractional inflow reserve procedure, let the physician know if these symptoms are experienced -

  • Casket pain.

  • The briefness of breath.

  • Fever.

  • Pain at the access point.

  • Dizziness.

  • An abnormal cardiac meter or pulsations.

Conclusion:

A fractional inflow reserve assessment can help the physician decide which treatment is suitable for the arteria coronaria complaint. They will console the patient as comfortably as possible during the test. Queries about the procedure are raised by the patient if there’s anything they do not understand. It is frequently helpful to organize oneself mentally just in case the patient would like an angioplasty and stent right after the physician calculates the fractional inflow reserve.

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Dr. Muhammad Zohaib Siddiq
Dr. Muhammad Zohaib Siddiq

Cardiology

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