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Tularemia - Causes, Symptoms, Diagnosis, Treatment, Complications and Prevention

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Tularemia is an infectious disease that typically affects the eyes, lymph nodes, skin, and lungs. Learn how you can prevent it.

Medically reviewed by

Dr. Sugreev Singh

Published At April 29, 2022
Reviewed AtDecember 20, 2022

Introduction:

Tularemia, which is also known as rabbit fever or deer fly fever, is an uncommon infectious disease that affects the eyes, lymph nodes, skin, and lungs. The causative organism is Francisella tularensis which is a bacteria. Mammals are most commonly affected by this disease, more specifically rodents, rabbits, and hares. The disease can also affect birds, domestic animals, sheep, etc. There are various routes of spread of this infection like insect bites and getting exposed to an infected animal directly. It is very contagious and can be life-threatening.

What Are the Symptoms of Tularemia?

The initial symptoms of the disease are visible in affected people within 3 days to 5 days, but it can take up to 14 days also. There are various types of tularemia, and the type depends on the affected site and mode of infection. Symptoms are specific to the type of infection. The following are the types of this disease,

1. Ulceroglandular Tularemia:

It is the most common type and may show the following symptoms:

  • An ulcer on the skin where the infection begins can be due to the bite of an insect or animal.

  • Painful swelling of the lymph glands or nodes.

  • Fever.

  • Tiredness.

  • Chills.

  • Headache.

2. Glandular Tularemia:

People who are infected with this type have almost similar symptoms as mentioned above in the ulceroglandular tularemia type, but these patients do not develop ulcers.

3. Oculoglandular Tularemia:

This type most commonly involves the eyes and may show the following symptoms,

  • Pain and redness in the eyes.

  • Sensitivity to light.

  • Swelling and discharge from the eye.

  • Formation of ulcer in the inner side of the eyelid.

4. Oropharyngeal Tularemia:

This type is most commonly caused due to the consumption of improperly cooked meat or contaminated water. The most commonly affected sites in this type are the mouth, digestive tract, and throat. The following are the signs and symptoms that are seen in this type,

  • Pain in the throat.

  • Fever.

  • Ulcers in the mouth.

  • Diarrhea.

  • Vomiting.

  • Inflammation in the tonsils.

  • Swelling of the lymph nodes in the neck.

5. Pneumonic Tularemia:

This type includes signs and symptoms that are typical of pneumonia and are as follows,

  • Dry cough.

  • Pain in the chest.

  • Difficulty in breathing.

6. Typhoidal Tularemia:

This type is very uncommon and serious. The signs and symptoms are as follows,

  • High fever.

  • Extreme exhaustion.

  • Vomiting and diarrhea.

  • Enlargement of the spleen which is called splenomegaly.

  • Liver enlargement (hepatomegaly).

  • Pneumonia.

If you suspect you have been infected with tularemia or have been in an area that has been known to have this disease, you should consult your physician as soon as possible.

What Are the Causes of Tularemia?

This disease does not occur naturally in human beings, and spreading through human-to-human contact has not yet been seen. Its prevalence is more in rural areas due to the presence of mammals and birds, etc. The organism can survive in soil, dead animals, and water for weeks.

This infection does not have a single route like other infections. It can spread through various routes. The symptoms and severity of the infection depend on the route of infection. The various routes through which this infection can spread are as follows:

  • Insect Bites - Ticks and deer flies are the most common vectors, and they cause mostly ulceroglandular tularemia.

  • Exposure to sick or dead animals.

  • Airborne - The bacteria can spread through the air.

  • Contaminated food or water.

It is known that heat can kill F. tularensis. Hence, it is advisable to cook meat at a minimum temperature of 165 F (73.8 C) so that the food is safe to eat.

Are There Any Risk Factors?

This disease can affect anyone, but some people can be at more risk of developing it, like those who are living in areas that are prone to this disease and also those who visit such places. People who are in certain occupations or have certain hobbies like hunting, gardening, etc., may develop this condition.

Are There Any Complications?

If this infection is left untreated, it can prove to be life-threatening. There can be certain other complications as follows:

1. Pneumonia or Inflammation of the Lungs -This can lead to failure of the lungs, and hence, respiration will be compromised.

2. Meningitis - It is the inflammation or infection of the brain and spinal cord.This can be fatal sometimes.

3. Pericarditis - Irritation or inflammation of the surrounding tissues or covering of the heart.

4.Osteomyelitis - A bone infection.

How Can Tularemia Be Prevented?

No vaccine has been invented yet for this type of infection, but the following measures can be followed to prevent this infection, especially for those who are prone to this condition via their occupation type.

  • Protect yourself from insects. This can be done using an insect repellent. If you are in mosquito-prone areas, then wear full sleeves clothes, and use mosquito repellants.

  • Taking precautions while gardening like wearing face masks, etc.

  • Wash hands after coming in contact with animals, and cook the meat completely at the proper temperature.

  • Take enough precautions to keep your pet animals safe.

How Can Tularemia Be Diagnosed?

This infection has similar symptoms to various other infections, and the physician can check your blood or sputum for the presence of F. tularensis using the culture method. Also, antibody testing can be done to identify the infection and microorganism. Also, a chest X-ray can be used to diagnose pneumonia.

How Can Tularemia Be Treated?

Antibiotics like Streptomycin or Gentamicin can be used to treat this infection, and they can be given via muscular or intravenous injection. Oral antibiotics can also be prescribed depending on the type of infection. If you have developed any complications, that will also be managed specifically.

Conclusion:

Tularemia is an infection that can cause certain complications if not managed on time. Online medical platforms have made a consultation with physicians or specialists easy. Hence, consult with your physician or specialist to get more details on this type of infection.

Frequently Asked Questions

1.

Which Conditions Are Associated with Tularemia?

Skin ulcers, inflamed eyes, sore throat, swollen and painful lymph glands, mouth sores, diarrhea, or pneumonia are some of the possible symptoms. Symptoms include fever, chills, headache, muscle aches, joint pain, dry cough, and increasing weakening if the bacteria is inhaled.

2.

What Is the Cause of Tularemia?

Tularemia, also called rabbit fever, is a bacterial infection caused by Francisella tularensis. Tularemia is most commonly found in animals, particularly mice, rabbits, and hares.

3.

How Does Tularemia Affect Humans?

Tularemia causes different symptoms depending on how people are exposed. Skin ulcers, sore throat, mouth sores, diarrhea, swollen and painful lymph glands, inflamed eyes, or pneumonia are possible symptoms.

4.

Does Tularemia Spread from One Human to Another?

Tularemia is most usually contracted through a bite from an infected tick or fly or through contact with an infected animal. Tularemia is transmitted to humans by sick pets or animals, but it is not transmitted from person to person.

5.

Is Tularemia a Kind of Plague?

Tularemia was first discovered and classified as a type of plague known as "pseudo-plague." Tularemia is a very rare infection. It affects the skin, eyes, lymph nodes, and lungs and is also known as rabbit fever or deer fly fever. Tularemia is caused due to the bacterium Francisella tularensis, which was discovered later. Rabbits, hares, and rodents like muskrats and squirrels are the most common victims of the disease.

6.

Is There a Treatment for Tularemia?

Antibiotics injected directly into a muscle or vein are an effective treatment for tularemia. Tularemia is most commonly treated with the antibiotic Gentamicin. Streptomycin is also effective, although it is more difficult to come by and has more adverse effects than other antibiotics.

7.

Does Tularemia Cure on Its Own?

Tularemia is very contagious and sometimes lethal, but if detected early enough, it can typically be treated efficiently with medications. Fever can be high and go away for a brief time before reappearing. The fever normally lasts four weeks if left untreated. The type of tularemia determines the other symptoms.

8.

Are There Any Long-Term Effects of Tularemia?

Tularemia rarely causes long-term consequences when treated promptly. If left untreated or treated late, the infection can spread to any part of the body, resulting in lung complications, including pneumonia.

9.

What Is the Incubation Period of Tularemia?

The duration between being exposed and becoming ill with tularemia is usually 3 to 5 days, although it can be anything from 1 to 14 days.

10.

How Do I Know If I Have Symptoms of Tularemia?

The majority of persons who are exposed to tularemia become sick within three to five days, though it might take up to 21 days. Tularemia can be classified into numerous forms, depending on how and where the bacteria enter the body. Skin ulcers, inflamed eyes, sore throat, swollen and painful lymph glands, mouth sores, diarrhea, or pneumonia are the signs to look for.

11.

What Is the Best Treatment for Tularemia?

The diagnosis can be confirmed with blood testing and cultures. Streptomycin, Gentamicin, Doxycycline, and Ciprofloxacin are some of the antibiotics used to treat tularemia. Based on the severity and type of the condition and the medications used, treatment usually lasts for 10 to 21 days.

12.

What Common Method Is Used to Confirm a Tularemia Infection?

Tularemia can be confirmed quickly and precisely using PCR (polymerase chain reaction) assay, which can also reveal the illness phase.

13.

Can Tularemia Be Fatal?

Tularemia is highly contagious, possibly lethal, and life-threatening, although medications can treat most infections successfully.
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Dr. Sugreev Singh
Dr. Sugreev Singh

Internal Medicine

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