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Urine Protein Test - An Overview

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Urine protein test assesses renal health by detecting protein levels. It assists in diagnosing renal disorders by identifying abnormal urine protein levels.

Published At February 15, 2024
Reviewed AtFebruary 15, 2024

Introduction

The amount of protein in urine is determined using a urine protein test. Urine usually has very little protein in it. Proteinuria, or elevated protein levels, may indicate renal problems. If the urine contains a significant quantity of protein, the kidneys, which are in charge of removing waste and extra water from the blood to create urine, can experience complications. Large, vital molecules called proteins, including the blood, are found throughout the body and are needed for normal physiological function. Small filters prevent large protein molecules from leaving the body through urine during the renal filtration of blood waste. Protein leakage into urine can happen when renal problems occur. Long-term high protein levels in the urine may be a symptom of kidney filter impairment or early kidney disease. Using a urine protein test allows for early/ diagnosis and protective measures to prevent further kidney damage.

What Is the Purpose of Undergoing a Urine Protein Test?

During routine checkups or if indications of renal disease are evident, the healthcare professional might request a urine protein test. Certain kidney disorders, such as chronic renal disease, may not show symptoms until later in life. Swelling, dry skin, exhaustion, altered urination patterns, bloody or frothy urine, appetite loss, cramping muscles, nausea, breathing difficulties, disturbed sleep, and cognitive problems are a few of the symptoms of kidney disease. Urine protein levels can be a sign of early kidney disease, which is why testing is recommended for those who are at high risk because of diabetes, high blood pressure, heart disease, family history, or medication use (such as NSAIDs like Ibuprofen and Naproxen Sodium), which can damage kidneys over time or other medical conditions.

What Is the Procedure of Protein in Urine Test?

No specific preparations are required for urine protein testing. A medical practitioner may supply a container, cleaning wipes, and directions for the "clean catch" technique for the test. To prevent contaminating the sample with skin bacteria, take the following actions:

  • Use water and soap to wash the palms of the hands.

  • Avoid touching the interior when opening the container.

  • On the genital region, use the cleaning wipe.

  • Urinate for a little period, then gather at least one ounce into the container without letting it come into contact with the body.

  • Complete the bladder emptying into the toilet.

  • Close the container and put it back as directed.

Inform the physician of bleeding menstrual flow or hemorrhoids if any. A 24-hour urine sample test could be necessary in some circumstances to investigate further. For a 24-hour urine sample, follow the specific instructions provided by the healthcare provider for collection and storage. The healthcare professional will send the urine sample(s) to a laboratory for analysis. To measure the amount of protein in the urine sample, a technician will use a dipstick with a color-changing indicator.

How to Prepare for Protein in a Urine Test?

Preparations for a urine protein test involve considering factors that may influence results:

  • UTIs, or urinary tract infections.

  • Dehydration.

  • The contrast agent used in certain imaging.

  • Intense exercise.

  • Certain drugs.

Rare reasons include previous prostate surgery or blood in the urine as a result of kidney stones.

What Do the Protein Urine Test Results Mean?

Urine's normal protein range is less than 150 mg/day, while various labs may measure different amounts. A value above this threshold suggests proteinuria or high protein levels in the urine. Increased protein levels can have a variety of transitory reasons, such as kidney stones, low blood pressure, inflammation, or dehydration.

While a protein urine test may not be able to identify a specific illness, it may warn medical professionals of potential issues. Increased amounts of protein might indicate more serious medical conditions such as multiple myeloma, kidney cancer, congestive heart failure, lupus, Goodpasture's syndrome, cardiovascular diseases, and chronic kidney disease.

The presence of a significant quantity of protein in a urine sample does not always mean that there is an urgent medical issue that needs to be addressed. Urine protein levels can temporarily rise as a result of several factors, including stress, pregnancy, nutrition, dehydration, and extreme physical exercise.

The healthcare practitioner could advise additional urinary testing to see whether the elevated protein levels are persistent. Urine protein levels that are consistently elevated may indicate renal disease or damage from other underlying diseases. The amount of protein in the urine is a good indicator of how much kidney damage there is, but additional investigation is required to determine the exact reason. It is recommended to discuss the results with a physician to fully understand the consequences.

What Are the Next Steps to Follow in Case of Abnormal Results?

Identifying the underlying reason and the most appropriate course of action are the next steps to take in the case of abnormal findings in the urine protein test. To identify the specific issues causing anomalies, further diagnostic testing could be advised. It is crucial to discuss these findings with the healthcare provider, who will guide one through the next steps and develop a suitable plan based on the identified factors.

Is It Possible to Conduct a Urine Protein Test at Home?

Urine protein test kits for use at home are available without a prescription. Dipsticks and instructions for gathering and analyzing a urine sample are usually included in these kits. The procedure is simple to follow, and accurate results can be achieved if the given directions are carefully followed.

When Should One Be Concerned after Normal Results on Urine Protein Test?

Informing the doctor of any new or worsening symptoms is important as it could contribute to additional diagnostic testing. Watch out for the following signs and symptoms:

  • Swelling (edema) of the feet, ankles, face, or belly.

  • Urine with foam.

  • Breathing difficulty (dyspnea).

  • Feeling tired.

  • Vomiting along with nausea.

  • Spasms in the muscles at night.

  • Increased urination frequency.

  • Edema around the eyes.

  • Reduced appetite.

Conclusion

Urine with elevated protein levels might be an indication of an underlying medical condition, such as renal disease, diabetes, urinary tract infection, or other associated issues. A protein urine test is a simple, non-invasive method to learn more about kidney function and gives medical professionals important information about kidney function and treatment options.

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Dr. Tuljapure Samit Prabhakarrao
Dr. Tuljapure Samit Prabhakarrao

Urology

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