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Understanding Non-24-Hour Sleep-Wake Disorder

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A rare circadian rhythm issue known as non-24-hour sleep-wake disorder throws off an individual's sleep-wake cycle, resulting in irregular sleep patterns.

Medically reviewed by

Dr. Basuki Nath Bhagat

Published At February 5, 2024
Reviewed AtFebruary 5, 2024

What Is Non-24-Hour Sleep-Wake Disorder?

A rare circadian rhythm problem that alters an individual's sleep-wake cycle is called non-24-hour sleep-wake disorder. Most people have an internal body clock that runs around 24 hours, while those who are non-24 have a longer sleep cycle and wakefulness. This indicates that their internal clock is out of sync with the standard 24-hour day-night cycle, resulting in erratic sleep patterns and making it challenging to stick to a regular sleep routine. Because completely blind people cannot detect light, their internal clock becomes out of sync with the outer world, which is why non-24 is more commonly observed in these people. Though it is far less common, it can also happen to sighted people.

What Are the Causes of Non-24-Hour Sleep-Wake Disorder?

The precise cause of non-24-hour sleep-wake disorder is unknown. However, it is thought to be connected to interference with the suprachiasmatic nucleus (SCN), a small part of the brain that regulates the circadian rhythm. A misaligned internal body clock results from the suprachiasmatic nucleus's inability to accept and process light-dark signals from surroundings in people with Non-24. In the case of blind people, the suprachiasmatic nucleus cannot synchronize with the external day-night cycle since these nuclei cannot perceive light. Changes in the suprachiasmatic nucleus or other brain areas that regulate the circadian rhythm may cause non-24 in sighted individuals.

What Are the Symptoms of Non-24-Hour Sleep-Wake Disorder?

The inability to stick to a normal sleep-wake schedule is the primary symptom of non-24-hour sleep-wake disorder. People who are non-24 may go through phases of being very sleepy during the day and having trouble falling asleep at night. These people might also experience insomnia, which would cause their sleep patterns to become disjointed. Additional indications of non-24 include diurnal fatigue, agitation, reduced focus, and compromised cognitive abilities. The way an individual functions daily and their general quality of life can be greatly impacted by these symptoms.

How to Diagnose Non-24-Hour Sleep-Wake Disorder?

Non-24-hour sleep-wake disorder is a rare and frequently challenging to diagnose condition. A complete medical history and a sleep evaluation are necessary for a diagnosis. The medical professional will ask about the patient's sleep habits, including the amount and timing of their sleep and any disruptions or challenges they may have had. One method to obtain objective information regarding an individual's sleep-wake cycle is actigraphy, which records sleep-wake patterns using a wrist-worn device. Excluding other sleep disorders that may give comparable symptoms is another step in the diagnosing process for Non-24.

What Are the Treatment Options for Non-24-Hour Sleep-Wake Disorder?

Non-24-hour sleep disorder has no known cure; however, numerous treatments can help control the symptoms and enhance sleep quality. The individual’s demands and preferences determine the therapy option.

  • Light Therapy: To help reset people's internal body clocks, light therapy exposes patients to intense artificial light, especially in the morning. In addition to helping the blind, light therapy may also help some seeing people who are non-24.

  • Melatonin: A hormone that aids in controlling the sleep-wake cycle is melatonin. Sleep quality can be enhanced by taking melatonin pills in the evening to help align the internal body clock. A healthcare provider should decide on the best time and dosage for melatonin.

  • Sleep Hygiene: People who are non-24 may find it helpful to maintain appropriate sleep hygiene. This entails keeping a regular sleep schedule, setting up a sleeping-friendly environment, and refraining from stimulants like caffeine right before bed.

What Are the Medications for Non-24-Hour Sleep-Wake Disorder?

Medication may occasionally be recommended to treat the symptoms of non-24-hour sleep-wake disorder. These drugs try to balance the sleep-wake cycle, lessen excessive drowsiness during the day, and enhance sleep quality. Medications that are frequently administered include:

  • Modafinil: Modafinil is a wakefulness-promoting drug that can help people with non-24 experience less daytime drowsiness and increased attentiveness.

  • Sedatives: People with non-24 may be administered sedative drugs, such as Benzodiazepines or non-Benzodiazepine hypnotics, to assist in falling and staying asleep at night.

What Are the Lifestyle Changes Made to Manage Non-24-Hour Sleep-Wake Disorder?

Certain lifestyle modifications can also assist people with non-24 in better managing their sleep-wake cycle, in addition to medication therapies. The changes to an individual's way of life are:

  • Creating a Consistent Sleep Schedule: The sleep-wake cycle can be regulated by going to bed and waking up at the same time every day, including on weekends.

  • Establishing a Sleeping-Friendly Atmosphere: Better sleep quality can be encouraged by creating a sleep-friendly environment in the bedroom by keeping it cold, quiet, and dark.

  • Limiting Stimulating Tasks Just Before Bed: Taking a warm bath or reading are examples of peaceful activities that help the body get ready for sleep.

What Are the Available Support and Resources for Non-24-Hour Sleep-Wake Disorder?

People with non-24-hour sleep-wake disorder and their families can receive resources and support, even though it can be challenging to live with. Online and in-person support groups give people a way to connect with others going through similar struggles. These organizations provide a feeling of belonging, understanding, and insightful knowledge about living with non-24. In addition to support groups, research papers, educational materials, and online resources provide additional explanations for non-24-hour sleep-wake disorder.

How Do People Cope With Non-24-Hour Sleep-Wake Disorder?

Non-24-hour sleep-wake Disorder demands self-care, understanding, and patience to cope with. The following guidelines can assist people in overcoming the difficulties associated with non-24:

  • Become Knowledgeable: To understand better non-24-hour sleep-wake disorder and how it affects life, try learning as much as possible about it.

  • Seek Out Expert Assistance: For an accurate diagnosis and an individualized treatment plan, speak with a medical expert specializing in sleep disorders.

  • Create Constructive Coping Strategies: Take part in stress-relieving activities to handle the psychological and emotional effects of non-24, such as journaling, meditation, or physical activity.

Conclusion:

A rare circadian rhythm disorder known as non-24-hour sleep-wake disorder can seriously impair an individual's sleep-wake cycle. It is essential to comprehend its causes, signs, and possible treatments to manage this condition effectively. Although there is no known cure for non-24, people with the condition can enhance their general well-being and quality of sleep with the use of light therapy, medicine, lifestyle modifications, and support. For an accurate diagnosis and management advice, seek medical attention from a professional if people believe that people are suffering from a non-24-hour sleep-wake disorder.

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Dr. Basuki Nath Bhagat
Dr. Basuki Nath Bhagat

Family Physician

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