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Dimethylaminoethanol in Cosmetics

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Dimethylaminoethanol is a commonly used skin care formulation that improves skin aging by improving skin firmness in facial muscle tone.

Written by

Dr. Swathi. R

Medically reviewed by

Dr. Dhepe Snehal Madhav

Published At December 29, 2022
Reviewed AtAugust 23, 2023

Introduction:

Dimethylaminoethanol (DMAE) is a commonly used formulation ingredient in skincare, cognitive function, and mood-enhancing products. The benefits of DMAE include a powerful anti-inflammatory effect and increased skin firmness by improving underlying facial muscle tone. Compared with other skin care regimens (for example, topical antioxidant creams), Dimethylaminoethanol is naturally produced inside the body and is also found in fishes as fatty fish, including salmon, sardines, and anchovies. It also helps to prevent the buildup of a substance called beta-amyloid, which is beneficial for brain health, especially at one age, when too much of this amyloid is linked to age-related decline and also loss in memory.

How Can One Use Dimethylaminoethanol?

Dimethylaminoethanol is a prescription drug for children with learning and behavioral problems. It is sold as dietary supplements in capsules and powdered forms. Dosing instructions may vary. Skincare products such as creams and lotions work as anti-aging, reducing wrinkle appearance, dark under-eye circles, and sagging skin.

What Are the Benefits of Dimethylaminoethanol?

Based on the studies, Dimethylaminoethanol shows the following potential benefits:

  • Reduce Wrinkles and Firm, Sagging Skin: It is found that facial gel containing three percent Dimethylaminoethanol is beneficial for reducing fine lines around the eyes and also on the forehead. In addition, studies show that it improves lip shape and fullness and the overall appearance of skin aging. It may also hydrate the skin and improve its appearance.

  • Support Memory: Dimethylaminoethanol may reduce memory loss associated with Alzheimer's disease and dementia.

  • Enhance Athletic Performance: Dimethylaminoethanol may improve athletic ability when combined with vitamins and other supplements.

  • Reduce Hyperactivity: Dimethylaminoethanol helps reduce hyperactivity in children, calms them, and helps them focus on school studies.

  • Support Better Mood: Dimethylaminoethanol helps enhance mood and overcome anxiety and irritability by increasing motivation and initiative.

Where Is Dimethylaminoethanol Contraindicated?

Dimethylaminoethanol should not be taken by people who may be affected by any of the following conditions:

  • Bipolar Disorder - Mood disorder with intense mood, energy level, and behavior shifts.

  • Schizophrenia - A disorder affecting a person's ability to think, feel and behave clearly.

  • Epilepsy - A disorder where brain nerve cell activity affects and causes seizures.

  • Spina Bifida - A neural tube defect in babies, which oral supplements may cause in the first few days of pregnancy. Avoid taking oral supplements if trying for pregnancy.

  • Recommended to avoid breastfeeding.

What Are the Potential Risks of Dimethylaminoethanol?

When taken by orally in high doses, inhaled, or used topically, it has been associated with several risks, which include:

  • Redness and swelling, such as skin irritation.

  • Muscle twitching - slight muscle contraction in the body.

  • Insomnia - sleep disorder making it hard to sleep.

  • Sneezing, wheezing, and coughing.

  • Severe eye irritation is seen.

  • Convulsions.

Potential drug interactions are seen in patients taking certain medications and should not take Dimethylaminoethanol. These medications include:

  • Acetylcholinesterase Inhibitors: These medications treat dementia (loss of memory) in Alzheimer's. Drugs affect acetylcholinesterase production in the brain and may cause a decline in mental abilities.

  • Anticholinergic Medications: These are medications used for various conditions, including Parkinson's disease (a disorder that affects the nervous system and body parts controlled by nerves), COPD (chronic obstructive pulmonary disease), and overactive bladder. Obstructing the effect of anticholinergic medications on nerve cells may increase the effect of this drug.

  • Cholinergic Medications: These drug types may block, increase, or show the same effects as anticholinergic drugs. They are used to treat systemic conditions such as glaucoma (a group of eye conditions that affects the optic nerve) and Alzheimer's disease (a brain disorder that slowly destroys the brain's thinking skills and memory and ability to carry out simple tasks).

  • Anticoagulants: These should be avoided while taking Dimethylaminoethanol if using blood-thinning medications such as Warfarin (it prevents blood from clotting, but it may take longer to stop the bleeding than usual).

Conclusion:

The benefits of using Dimethylaminoethanol in cosmetics have some benefits for the skin. In addition, consuming the drug might help overcome hyperactivity, mood, thinking ability, and memory. However, please consult a doctor before taking it. It is necessary to avoid it in case of pregnancy.

Frequently Asked Questions

1.

Why Is DMAE Prohibited?

DMAE is produced naturally in the body. Deanol was a prescription medicine in which DMAE was the main ingredient used to treat children's learning and behavioral issues. It was withdrawn after insufficient proof suggesting the medicine was effective.

2.

What Are the Advantages of Using DMAE Skincare?

DMAE may help improve the appearance of aging skin by increasing skin firmness and decreasing inflammation. Topical (on the skin) usage of DMAE can reduce wrinkles, dark under-eye circles, and neck firmness, and these effects lasted for up to two weeks after the gel was stopped.

3.

Is Dimethylaminoethanol Safe for Human Use?

DMAE has been linked to many possible risks, whether taken orally in high doses, inhaled, or applied topically. These include skin irritation, such as redness and swelling, muscular twitching, sleeplessness, sneezing, coughing, wheezing, extreme eye irritation, and convulsion (this is only a minor risk for those who are vulnerable).
 

4.

Is DMAE Authorized by the FDA?

The FDA has approved a human trial of DMAE (no salt form accessible), with a daily dose of 200 mg (2.20 mmol) recommended. Clinical study doses ranged from 300 to 2000 mg/day (3.30 to 22.20 mmol/day). There are no significant negative effects with DMAE doses as highneeds to be more200 mg/day (13.46 mmol/day). There is no information on how the free base of DMAE was administered.

5.

Can I Combine DMAE and Retinol?

DMAE is compatible with retinol. When retinol works together with DMAE, it greatly promotes collagen synthesis and increases the number of dividing in the basal skin layer, and epidermal thickness.

6.

What Is the Purpose of Dimethylethanolamine?

DMAE is a new chemical that was initially used to treat hyperkinetic diseases and improve memory. Because of its function as a precursor to acetylcholine, it is currently utilized extensively in cosmeceutical products. Initially used as a firming and anti-aging treatment, but is now also known for its anti-inflammatory and antioxidant properties.
 

7.

What Is the Method for Applying DMAE Powder to Your Skin?

DMAE is an alkaline chemical substance that is frequently used with tartaric acid in skin care products. It is available in DMAE Bitartrate and should be used at a concentration of 3 to 5 percent in formulations for optimal benefit. Because it is water-soluble, it should be introduced to an emulsion during the water phase. DMAE is suitable for the majority of products and has no known side effects. 

8.

Is DMAE Toxic to Cells?

After DMAE is applied to cells, the cells are essentially harmed from the inside out. As a result of cells ceasing to proliferate, numerous cells die after 24 hours of treatment.

9.

Is DMAE the Same as DMAA?

DMAE is mainly recognized for its cognitive benefits, such as increased memory and concentration. DMAA, on the contrary, tends to be found in pre-workout, primarily employed largely for its stimulant properties.

10.

Is DMAE Suitable for Vegans?

Bakuchiol is a plant-derived ingredient that is a natural alternative to retinol, a type of vitamin A used for treating skin aging, acne, and sun damage. Bakuchiol has similar beneficial effects as retinol in terms of collagen production and wrinkle reduction, but it is less irritating and better suited for sensitive skin.

11.

What Exactly Is DMAE-Hyaluronic Acid?

DMAE-hyaluronic acid is a potent combination of 2.5 percent hyaluronic acid and 3 percent DMAE used for wrinkle treatment. TheCombining is instant. The combination of hyaluronic acid and DMAE slows the aging process by boosting the function of fibroblasts and collagen formation.

12.

How Should You Apply DMAE Cream?

Dry the surface of the face before applying DMAE cream. It is advised to apply the cream to the skin twice a day, in the morning and evening.

13.

Can You Combine DMAE and Vitamin C?

DMAE promotes the benefit of vitamin C by helping in the reduction of fine lines and wrinkles, resulting in a tighter, firmer, more "lifted" facial appearance.

14.

Can I Combine DMAE and Tretinoin?

Tretinoin is instantly active but far more potent. As a result, it is also more potent, but it can also be more harmful to the skin if not used correctly. Tretinoin benefits greatly from the addition of DMAE. When Tretinoin is used, there is less dead skin on the surface. The DMAE serum has the potential to improve and heal dry skin.
 
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Dr. Dhepe Snehal Madhav
Dr. Dhepe Snehal Madhav

Venereology

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