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Macule vs Papule - An Overview

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A macule is a flat, erythematous region of skin that appears in a rash. A papule is a skin rash that is an elevated region of skin.

Written by

Dr. Palak Jain

Medically reviewed by

Dr. Kaushal Bhavsar

Published At December 22, 2023
Reviewed AtDecember 22, 2023

Introduction

Skin lesions are the term used to describe a wide range of abnormalities, including skin manifestations like spots, blisters, swellings, etc. A flat, non-infiltrating skin lesion known in dermatology as a "macula" is defined as having a different color from the surrounding skin.

A small hemorrhage, a change in pigmentation, or inflammatory infiltrates are a few examples of the various causes of the macules. An absence of pus separates a papule from a pustule, a tiny, solid, often conical lump on the skin. In addition to a rash, papules frequently develop in groups. The terms papulosis and papillomatosis refer to a disorder that results in papules.

What Is Macule and Papule?

Both skin disorders affect the skin. Both are dermatological symptoms (skin issues) that might be localized or systemic diseases. Conversely, a papule is an elevated white lesion smaller than 0.5 cm in diameter. In contrast, a macule is a non-elevated area of discolored lesion on the skin.

1. Size:

  • Macule - Less than 1 cm.

  • Papule - More than 1 cm.

2. Layers of Skin Involved:

  • Macule - Only dermis.

  • Papule - Proliferation of superficial or epidermal cell types.

3. Type of Lesion Involved:

  • Macule - Flat region with modified texture or color.

  • Papule - Raised solid lesion.

What Is Macule?

A tiny lesion (often less than 1 cm in diameter), flat, non-palpable, and discolored, can be brown, tan, red, or white, and its texture is the same as the skin around it.

Medical diseases that frequently cause macular rashes include:

  • Adverse effects from certain drugs.

  • Allergic diseases like inflammatory illnesses.

  • EBV (Epstein-Barr virus) and hepatitis B infections are examples of infectious diseases.

What Is Papule?

It is a solid, raised cutaneous lesion of 1 cm in diameter. It can appear in several hues, including red, purple, brown, pink, and yellow-brown.

It can affect the trunk extremities and the face, frequently on the eyelids or alar rim.

What Are the Etiological Differences Between Macule and Papule?

Macule:

Different disorders that affect the appearance of the skin's color and texture might generate macules, which can result in discolored patches.

The following conditions are likely to result in macules:

  • Vitiligo, or pigment-losing skin lesions, in patches.

  • Moles are frequent non-cancerous skin growths that are often dark brown and are brought on by collections of cells with pigment.

  • Freckles (minuscule brown spots on the skin that often appear in sun-exposed regions).

  • Age, sun, and liver spots.

  • Dark patches that remain after a pimple heals, such as those that emerge after acne lesions heal, are known as post-inflammatory hyperpigmentation (PIH).

  • Tinea versicolor (a common skin fungus infection).

Papule:

In general, the following are the main causes of papules (raised lumps or elevations on the skin):

  • A surplus of oil is produced.

  • Infection with bacteria.

  • Increased androgen (male sexual hormone) activity.

  • Leishmaniasis (a parasite illness that causes anemia, irregular fever episodes, weight loss, enlarged spleen and liver, and irregular bouts of fever).

  • Several types of vasculitis.

Acne (papules) may also be brought on by or made worse by:

  • Stress and anxiety.

  • Processed foods or diet (too high sugar intake).

  • Several medications, such as corticosteroids.

What Are the Treatment Modalities That Are Used to Treat Macule?

Treatment options varied greatly due to the large variety of causes of macules. Even though addressing the underlying cause of the macules may not completely eradicate them, it may help stop them from spreading further. It could also stop the growth of fresh macules. Vitiligo-related macules are frequently challenging to manage. Treatment options for vitiligo-related macules include:

  • Surgery.

  • Topical steroids.

  • Light therapy.

Some people could decide against medical care and instead use cover-ups like cosmetics. In rare cases, bleaching or peeling chemicals may be helpful. In general, limiting one's exposure to the sun can reduce the likelihood of developing macules on the skin. Dermatologists regard hydroquinone-containing treatments as the best option for eradicating dark spots since they reduce pigment synthesis. These products can be used alone or in combination with other lighteners. According to the US Food and Drug Administration (FDA), they are accessible with a prescription.

What Are the Treatment Modalities That Are Used to Treat Papule?

The doctor could advise using over-the-counter acne medications like salicylic acid or benzoyl peroxide at first. The dermatologist could advise topical Dapsone for acne that is inflamed. Further recommendations relevant to the issue may be:

1. Antibiotics - Topical antibiotics can eradicate extra germs on the skin and lessen inflammation. Typically, they are used in conjunction with other therapies, such as Erythromycin and benzoyl peroxide or Clindamycin and benzoyl peroxide. Antibiotics may occasionally be used with retinoids.

2. Retinoid and Retinoid-Like Medications - Retinoids include Adapalene, Tretinoin, and Tazarotene.

Dermatologists may advise oral drugs depending on the severity of the acne:

1. Antibiotics - Examples include a tetracycline like Doxycycline or Minocycline or a macrolide like Azithromycin or Erythromycin.

2. Pills for Female Contraception - Ortho Tri-Cyclen or Yaz, which combine estrogen and progestin, can treat acne.

3. Antiandrogenic Drugs (For Women) - Oil glands can be affected by androgen hormones, which is why Spironolactone can inhibit this effect.

Conclusion

Skin lesions can vary in size, form, and location on the body and are fairly frequent. Inconspicuous skin lesions just alter the appearance of the skin and pose no risk to general health. If an individual does not like how a certain type of skin lesion looks on the skin's surface, the provider may have treatment choices that work for them or may be able to remove it. The majority of cutaneous lesions are present. Topical lotions, creams, ointments, and oral drugs that target the particular type of lesion can be used to treat them, or they might need to be removed surgically. To know more about the condition, consult the doctor online.

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Dr. Kaushal Bhavsar
Dr. Kaushal Bhavsar

Pulmonology (Asthma Doctors)

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