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Herpangina and Pregnancy - Risks and Precautions

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Herpangina can cause adverse pregnancy outcomes and thus needs special attention. Read the article to know more about it.

Medically reviewed by

Dr. Shubadeep Debabrata Sinha

Published At December 1, 2023
Reviewed AtDecember 1, 2023

What Is Herpangina?

Herpangina stands as a viral ailment characterized by the presence of ulcers and lesions within the oral cavity, accompanied by a sore throat and elevated body temperature. Herpangina predominantly affects children and is a prevalent childhood infection. While it is commonly observed in children aged three to ten, it can manifest in individuals of all age groups.

The primary causative agents are typically viruses from the Coxsackie group A. These viruses are easily transmissible, and the risk of herpangina increases if an individual at school or home is afflicted with the illness. The condition's clinical manifestations may encompass headache, fever, decreased appetite, ulcerations within the oral and throat regions, as well as similar sores appearing on the hands, feet, and buttocks, painful swallowing, or a sore throat. The ulcers typically exhibit a base that ranges from white to whitish-gray, accompanied by a red border. They often induce significant discomfort. Usually, the number of sores is limited in most cases. Formal tests are generally not imperative. Typically, healthcare providers diagnose this condition through a physical examination and inquiries regarding the child's medical history and symptoms.

What Potential Risks Can Arise From Herpangina During Pregnancy?

The association between herpangina and pregnancy raises concerns about potential risks and necessary precautions for expectant mothers. Herpangina, characterized by oral ulcers, sore throat, and fever, could potentially impact pregnancy outcomes. Pregnant women should consider taking precautions to minimize the risks, such as practicing good hygiene, seeking medical advice promptly if symptoms arise, and adhering to appropriate clinical management strategies. It is important to address this potential risk to ensure the well-being of both the mother and the developing fetus.

  • Maternal Health: Pregnant women with herpangina might experience discomfort due to the symptoms of the illness, which can include fever, sore throat, and mouth ulcers. These symptoms might contribute to overall discomfort and hinder proper nutrition and hydration, potentially affecting the mother's well-being.

  • Dehydration: The presence of painful mouth ulcers can make eating and drinking challenging, leading to a risk of dehydration. Dehydration during pregnancy can have adverse effects on both the mother and the baby.

  • Fetal Health: While herpangina itself does not usually directly affect the fetus, there is a concern about the potential transmission of the virus to the baby. Certain viral infections during pregnancy can lead to congenital issues or other complications in the baby, although herpangina is generally considered to have a low risk of causing such problems.

  • Potential for Spread: Herpangina is caused by viruses that are contagious. If a pregnant woman contracts herpangina, there is a possibility of spreading the virus to others, including close contacts and healthcare providers.

  • Low Birth Weight: There is limited direct evidence linking herpangina to an increased risk of having a low birth weight (LBW) baby. LBW is usually associated with factors like maternal health, nutrition, prenatal care, and certain medical conditions rather than viral infections like herpangina. However, if herpangina leads to dehydration and significant discomfort, it could potentially indirectly affect the mother's overall health and nutrition, which might have an impact on fetal growth. Severe dehydration and inadequate nutrient intake during pregnancy can contribute to LBW.

  • Preterm Labor: While there is not a direct and established link between herpangina and preterm birth, certain viral infections during pregnancy can potentially increase the risk of preterm birth or labor. Herpangina is caused by Coxsackie viruses, and some viral infections have been associated with an increased risk of preterm birth due to their impact on the immune system and inflammatory response. The primary concern in cases of viral infections during pregnancy is the potential activation of the maternal immune system, which can trigger inflammation. Inflammation has the potential to affect the uterine environment and lead to contractions or early labor.

  • Small for Gestational Age: SGA refers to infants whose birth weight is lower than expected for their gestational age. This condition is usually influenced by factors such as maternal health, genetics, placental function, and nutritional intake during pregnancy. Herpangina, caused by Coxsackie viruses, typically presents with symptoms like mouth ulcers, sore throat, and fever. While the primary concern during herpangina is the discomfort and potential dehydration for the mother, there's limited evidence to suggest a direct link between this viral infection and SGA.

  • Others: It is prudent to consider the diverse influences of covariates on pregnancy outcomes. Generally, akin patterns of effects were evident for both low birth weight and SGA outcomes. Moreover, factors such as marital status, monthly income, infant characteristics like gender, and parity were significantly correlated with unfavorable pregnancy outcomes. Incorporating attributes that have been previously linked to adverse birth outcomes into our regression models, discerned that these covariates might potentially confound the impact of herpangina on LBW and SGA.

What Precautions Should Pregnant Women Take if They Have Herpangina?

  • The need to proactively prevent herpangina infection is necessary in order to mitigate the risks of negative pregnancy outcomes in expectant mothers.

  • Given their vulnerability and the potential for placental transmission to the fetus, pregnant women should exercise vigilant precautions to curtail the potential for herpangina transmission via the fecal-oral route.

  • Effective hygienic measures, such as thorough handwashing and avoidance of contaminated food, are pivotal preventive strategies. These practices should be supplemented by bolstering the immune system through factors like a balanced diet and regular physical activity.

  • Furthermore, pregnant individuals should remain vigilant for any signs of vesicular exanthema affecting the fauces and soft palate, accompanied by symptoms like sore throat, fever, and discomfort while swallowing.

  • It is imperative to promptly inform the obstetrician if such symptoms manifest, particularly if herpangina is contracted during the initial and middle trimesters. In such cases, heightened monitoring and closer evaluation—such as ultrasound examinations—are advisable during the subsequent gestational period to ensure the proper development of the fetus.

Conclusion

Maternal contraction of herpangina amplifies the jeopardy of unfavorable pregnancy consequences, encompassing conditions like low birth weight (LBW), preterm birth, and small for gestational age (SGA) infants. Studies underscore a notable potential risk associated with this typically mild ailment when experienced by pregnant individuals. In addition to providing preventative guidance, healthcare professionals should diligently supervise and implement appropriate clinical management strategies for pregnant women afflicted with herpangina. Further studies are essential to substantiate herpangina as an independent risk factor for adverse pregnancy outcomes. Moreover, future research should delve into the potential mechanisms that interconnect herpangina with these unfavorable birth consequences.

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Dr. Shubadeep Debabrata Sinha
Dr. Shubadeep Debabrata Sinha

Infectious Diseases

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