HomeAnswersGeneral Practitionerchronic fever

What are the tests that determine the cause of chronic fever?

This Premium Q&A, reviewed and published, features a real conversation between an iCliniq user and a physician.

Patient's Query

Hello doctor,

I am 19 years old, weigh 121 pounds, and am 5.3 feet tall. I have been experiencing low-grade fever for six months. My IGRA test came back positive, but my sputum test was negative, and my CT scan showed normal results. Currently, I am experiencing a fever multiple times daily, around 101°F, along with sweating and chills, and I am taking Paracetamol. What tests should I undergo further?

Please help.

Thank you.

Answered by Dr. Nagaraj Malipatil

Education:

MBBS

Professional Bio:

Dr. Nagaraj Malipatil is a specialist in internal medicine, internal medicine, and diabetology. He has expertise in managing chronic conditions such as diabetes, hypertension, thyroid disorders, and other lifestyle-related illnesses. Known for his patient-focused and holistic approach, Dr. Malipatil is dedicated to providing accurate diagnoses and long-term treatment plans tailored to each individual’s health needs.

This doctor is not available for online consultations on the platform anymore.

Hello,

Welcome to icliniq.com.

The interferon-gamma release assays (IGRA) test is unable to differentiate between latent and active tuberculosis (TB) infection, essentially distinguishing between infection and disease. Just because you are infected with TB does not mean you have the disease, which is why your sputum test and CT (computed tomography) findings were negative. Close to 70 to 80 percent of people in a developing country are infected with TB, but not all develop the disease. Based on your history, I would recommend undergoing testing for malaria, including a rapid diagnostic test (RDT) and peripheral smear, especially if you are experiencing intermittent fever with chills.

If you also have symptoms such as burning during urination or pain before, during, or after urination, it could indicate a urinary tract infection, which is common in females. I recommend getting a urine routine test to confirm. When fever persists for more than 21 days and the cause cannot be identified despite thorough investigations, it is termed a fever of unknown origin. At this stage, I suggest undergoing the following tests to provide some insight:

  1. Complete blood count (CBC) with detailed differential counts and morphology.
  2. Erythrocyte sedimentation rate (ESR).
  3. Urine routine examination.
  4. Peripheral smear for malaria parasites.

To order additional tests, I would need a more detailed history of your symptoms, which is not feasible at this time.

I hope this information is helpful. Please do not hesitate to reach out if you need further assistance.

Thank you.

Medically reviewed by iCliniq medical review team
Published At March 22, 2024
Reviewed At February 3, 2026

Education:

MBBS

Professional Bio:

Dr. Nagaraj Malipatil is a specialist in internal medicine, internal medicine, and diabetology. He has expertise in managing chronic conditions such as diabetes, hypertension, thyroid disorders, and other lifestyle-related illnesses. Known for his patient-focused and holistic approach, Dr. Malipatil is dedicated to providing accurate diagnoses and long-term treatment plans tailored to each individual’s health needs.

This doctor is not available for online consultations on the platform anymore.

Same symptoms don't mean you have the same problem. Consult a doctor now!

Education:

MBBS

Professional Bio:

Dr. Nagaraj Malipatil is a specialist in internal medicine, internal medicine, and diabetology. He has expertise in managing chronic conditions such as diabetes, hypertension, thyroid disorders, and other lifestyle-related illnesses. Known for his patient-focused and holistic approach, Dr. Malipatil is dedicated to providing accurate diagnoses and long-term treatment plans tailored to each individual’s health needs.

This doctor is not available for online consultations on the platform anymore.

Listen to related tracks in our music library
Comprehensive Second Opinion

Ask your health query to a doctor online

*guaranteed answer within 4 hours

Disclaimer: No content published on this website is intended to be a substitute for professional medical diagnosis, advice or treatment by a trained physician. Seek advice from your physician or other qualified healthcare providers with questions you may have regarding your symptoms and medical condition for a complete medical diagnosis. Do not delay or disregard seeking professional medical advice because of something you have read on this website. Read our Editorial Process to know how we create content for health articles and queries.