I have diabetic neuropathy and require medications for leg pain. Kindly help.

Q. What are the medications given for leg pain caused due to diabetic neuropathy?

Answered by
Dr. Hitesh Kumar
and medically reviewed by iCliniq medical review team.
This is a premium question & answer published on Jan 17, 2023

Hello doctor,

I have diabetic peripheral neuropathy and require medicine for my leg pain. However, my blood sugar is normal.

Thank you.



Welcome to icliniq.com.

I would like to know some details about your symptoms:

1. Since when do you have diabetes mellitus?

2. Since when you started to have pain in your leg?

3. Is pain in both legs or one? If one, which side?

4. Kindly mention whether you have pain in the hip, thigh, knee joint, calf region, ankle joint, foot, or elsewhere.

5. What is the character or type of pain? For example, is it burning, tingling, electric currents like pins, needle sensation, stretching, heaviness, or some other kind?

6. Is the pain persistent or intermittent?

7. If intermittent, in which situation does it get worse or triggered? For example, sitting, standing, walking, bending down, daytime, nighttime, by local touch or pressure, or something else?

8. As you mentioned, it is diabetic neuropathy. Have you undergone any investigation to make a diagnosis of the cause of pain? If yes, please share the reports.

9. Are you on any medications already for this pain? If yes, please mention the name, dose, and number of times you take it. Also, please mention any benefits, symptomatic relief, or side effects you felt on taking that medicine.

10. Do you have any lower back pain?

11. How is your sleep? Does the leg pain affect your sleep?

12. Do you have any other associated co-morbid medical conditions? If yes, please mention it.

Kindly revert with the information mentioned above for better understanding and further judgment.

Thank you.

Regarding follow up:

Revert with the above-mentioned information for better understanding and further judgment.

Hello doctor,

I have been diabetic for the past ten years. I have had severe foot pain for the past 30 days. The pain in the left foot is severe, whereas the pain in the right is little. I have pain only in the foot. The pain feels like pins and needles and is intermittent. The pain occurs only at night. The doctor advised taking the Duloxetine capsule, Pregabalin and Nortryptylin, and Methylcobalamin 1500 mcg. Renerve injection once a week. There is no back pain at present. The foot pain does not disturb sleep. I am taking antipsychiatric drugs D-Venize (Desvenlafaxine), and Qutipin for depression and sleep.

Thank you.



Welcome back to icliniq.com.

Did you get symptomatic relief (partially) by taking Pregabalin NT (Pregabalin and Nortriptyline) twice daily? If yes, approximately how much? Have you started taking Duloxetine along with Pregalin NT? D-Veniz (Desvenlafaxine) and Duloxetine belong to the same group, SNRI (Serotonin–norepinephrine reuptake inhibitors), which is better not taken simultaneously. D-Veniz is primarily for depression and anxiety, but a significant role in neuropathic pain has not been mentioned. Duloxetine also helps with depression and along with its role in neuropathic symptoms. But first, discuss with your psychiatrist if D-Veniz can be switched to Duloxetine for psychiatric symptoms or not.

Other treatment options for neuropathic pain are:

Consult your specialist doctor, talk to them, and take medications after their consent.

  1. Increase the night dose of Pregabalin.
  2. Take Carbamazepine.
  3. Topical application of Gabapentin ointment on feet during the night.

Get the following investigations done:

  1. Nerve conduction study of all four limbs.
  2. MRI LS (magnetic resonance study of the lumbar and sacral region of the spine) with the whole spine screening.
  3. Serum Vitamin B12.

Thank you.

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