Are there any promising drugs under trial for dry AMD?

Q. Do you have any thoughts on promising drugs for dry AMD?

Answered by
Dr. Asif Manzoor
and medically reviewed by iCliniq medical review team.
This is a premium question & answer published on Dec 21, 2016 and last reviewed on: Dec 18, 2021

Hello doctor,

I am 63 years old. I was diagnosed with dry intermediate AMD about five years back. The VA then was 20/25, and now it is 20/60. I am currently on AREDS. I am a non-smoker. I have excellent health otherwise. The Amsler is normal. The recent OCT showed no fluid. Do you have any thoughts on promising drugs like Fenretinide, statins, or others under trial or research?



Welcome to

For dry AMD (age-related macular degeneration), the recommendations mostly include AREDS2 (Age-related Eye Disease studies 2) formulation. The other recommendations are quitting smoking (in case of smokers), controlling hypertension, lipid level, diabetes, and regular checking with an Amsler chart to pick early conversion of dry AMD into wet AMD. Your decrease in vision over five years may be due to lens changes or cataracts; you have not mentioned the cataract surgery done or not. If there is no fluid or change on Amsler, then AREDS and other preventive measures are enough. Trials are underway on Fenretinide as that decreases cytotoxins production in the retina. The other trials being done include Saffron 20 mg/day. The evidence suggests that it is neuroprotective but needs more research and authentic results. These are still under trial, and there are no recommendations available. More treatment options are available for wet AMD as it is a vision-threatening condition. There are intravitreal injections and lasers (PDT- photodynamic therapy) options.

I would advise you to stick with the current therapy of AREDS and keep testing with Amsler. Keep in touch with your eye doctor about any new modality introduced for dry AMD. He will inform you.

Probable diagnosis:

Dry AMD.

Treatment plan:

AREDS and keep testing with Amsler.

Preventive measures:

Stop smoking, control BP, blood sugar and lipid level.

Hi doctor,

Thank you for the reply.

Saffron seems interesting. I have not had cataract problems, but I forgot to mention that my right eye can only count fingers due to childhood trauma, corneal tear at the age of eight years. I wonder the step an ophthalmologist would take in my situation. I will discuss this with him soon.



Welcome back to

It is unfortunate to hear about your second eye. So, your left eye will be considered the only eye and precious one. There will be RPE (retinal pigment epithelium) and atrophic changes in dry AMD. They can also decrease vision if the cataract is not significant. The swept-source OCT (optical coherence tomography) can better view the RPE layer. I hope that will be available at every eye clinic.

Hi doctor,

Thank you. Have a happy year ahead.



Welcome back to

Thank you. May God bless you with healthy and successful life in coming years. Best wishes.

Was this answer helpful?


Same symptoms doesn’t mean you have the same problem. Consult a doctor now!

Related Questions:
Why is there weird formation of characters in front of my eyes?

.. call them floaters according to your description. Those are formed hallucinations. First, you have to know whether there is any organic abnormality like parietal lobe lesions in your brain affecting the visual pathway.   Read full

Age-Related Eye Disorders and Their Conservative Prevention Measures

.. important of our bodily senses for daily activities and for work. Just imagine a situation wherein we would have to dress ourselves up for work, eat, drive and work without using our vision. This should give you a good perspective.   Read full

Can I play football again after retinal tear?

.. have to say no. The fact that you have had a retinal tear which had to be treated by laser tells me that you are at future risk of another tear. The tear by itself can progress to retinal detachment and can permanently decrease the visual acuity of you   Read full

Also Read Answers From:

ideaComprehensive Medical Second Opinion.Submit your Case

Also Read

PCOS and Liver Problems
The hormonal imbalances in polycystic ovary syndrome could cause liver diseases. Read the article to know the relationship between these medical conditions.  Read more»
Inferior Alveolar Nerve Lateralization Technique
The inferior alveolar nerve lateralization technique is a surgical lateralization technique to reposition the nerve. Read the article to know more about this.  Read more»
COVID-19 and Ebola: Similarities and Differences
This article gives a comparison and broader overview of the outbreak of the two deadliest diseases that showed a greater incidence over the last two decades.  Read more»

Ask your health query to a doctor online?

Ask an Eye Care Ophthalmologist Now

* guaranteed answer within 4 hours.

Disclaimer: No content published on this website is intended to be a substitute for professional medical diagnosis, advice or treatment by a trained physician. Seek advice from your physician or other qualified healthcare providers with questions you may have regarding your symptoms and medical condition for a complete medical diagnosis. Do not delay or disregard seeking professional medical advice because of something you have read on this website. Read our Editorial Process to know how we create content for health articles and queries.