Alpha 2 Globulin and Gamma Globulin are High. What Does This Mean?

Q. My alpha 2 globulin and gamma globulin are high. What does this mean?

Answered by
Dr. Ashaq Hussain Parrey
and medically reviewed by iCliniq medical review team.
This is a premium question & answer published on Apr 09, 2018 and last reviewed on: Jul 13, 2023

Hello doctor,

I tested positive for an autoimmune disease. My titers were 1280. I then had more blood work done by a rheumatologist and just now received some back online. I noticed my alpha 2 globulin was high (1.12) and my gamma globulin was pretty high as well. The rest were normal on the protein electrophoresis. What does this mean?



Welcome to

You have not mentioned which autoimmune disease test has come positive. High levels of alpha 2 globulin are seen when there is a loss of albumin via urine because alpha 2 is a large molecule. It does not pass kidney filtration. So, it is retained because it is a component of globulin. That is the reason for high levels of globulin in the blood. You need to test your 24-hour urinary protein which will tell whether you are losing protein in urine or not.

Thank you.

Hello doctor,

They have not given me an exact diagnosis. My family doctor got the positive ANA and sent me to a rheumatologist whom I have only seen once for the blood work I just had. He said my blood work from my family doctor showed inflammation in my body and given my symptoms of fatigue, body aches, headaches, low-grade fevers, and joint pain, he put me in Plaquenil to start with. I see him again in three months and I have not heard back yet about my blood work because I am waiting on the results. He did a urinalysis and it was negative for protein but did have blood in my urine along with red blood cells and white blood cells, high epithelial cells. Could this mean anything along with high alpha 2 and gamma? I am waiting on anti-u1rnp and DNA AB double-strand ELISA results.



Welcome back to

There is a possibility of SLE (systemic lupus erythematosus) or UCTD (undifferentiated connective tissue disease). So, Plaquenil (Hydroxychloroquine) is a good drug at this stage as suggested by your symptoms. So, just wait for the rest of the investigations. They will guide us for future treatment.

Thank you.

Was this answer helpful?


Same symptoms doesn’t mean you have the same problem. Consult a doctor now!

Related Questions:
Is my ANA titer high due to Hashimoto's thyroiditis?

.. your concern. Such a high tire ANA (antinuclear antibodies) with centromere positive and musculoskeletal and systemic complaints is usually associated with Sjogren's syndrome, MCTD (mixed connective tissue disease).   Read full

What do elevated kappa light chains and IgM indicate?

.. seen the reports (attachment removed to protect patient identity). IgM and kappa can be raised in any acute infection. Mixed infection probably started with viral and superadded bacterial infection.   Read full

What is the cause of my recurrent strokes and TIA?

Other causes might be cancer or arthritis, which I do not have ...   Read full

Also Read Answers From:

ideaComprehensive Medical Second Opinion.Submit your Case

Also Read

PCOS and Liver Problems
The hormonal imbalances in polycystic ovary syndrome could cause liver diseases. Read the article to know the relationship between these medical conditions.  Read more»
Inferior Alveolar Nerve Lateralization Technique
The inferior alveolar nerve lateralization technique is a surgical lateralization technique to reposition the nerve. Read the article to know more about this.  Read more»
COVID-19 and Ebola: Similarities and Differences
This article gives a comparison and broader overview of the outbreak of the two deadliest diseases that showed a greater incidence over the last two decades.  Read more»

Ask your health query to a doctor online?

Ask a Rheumatologist Now

* guaranteed answer within 4 hours.

Disclaimer: No content published on this website is intended to be a substitute for professional medical diagnosis, advice or treatment by a trained physician. Seek advice from your physician or other qualified healthcare providers with questions you may have regarding your symptoms and medical condition for a complete medical diagnosis. Do not delay or disregard seeking professional medical advice because of something you have read on this website. Read our Editorial Process to know how we create content for health articles and queries.