Can Hashimoto's thyroiditis result in high ANA titer?
ADVERTISEMENT

Q. Is my ANA titer high due to Hashimoto's thyroiditis?

Answered by
Dr. Sayan Mukherjee
and medically reviewed by Dr. Sneha Kannan
This is a premium question & answer published on Aug 27, 2020 and last reviewed on: Nov 04, 2022

Hi doctor,

I have had an autoimmune reaction for a year now. Symptoms include fatigue, joint and muscle pain, fever spikes (never above 100oF), 40 lbs weight gain in five months, trouble losing weight, swelling, random rashes, heart palpitations, brain fog, migraines, stomach aches, etc. I am currently going through the whole diagnosis process of an autoimmune disease. I have a positive ANA titer of 1:5120 with a homogenous pattern. We narrowed down most of my issues to Hashimoto's thyroiditis. However, I am tested positive for centromere B antibody, Anti-thyroid peroxidase antibody, anti-cardiolipin antibody, and negative for lupus and celiac, smooth muscle antibody, and mitochondrial antibodies. My urea nitrogen (BUN) is low, and ALT is high. I was wondering what that means and if it is something I should worry about.

Current medication details:

Birth control pills, Iron supplements, tablet Topamax ( Topiramate), tablet Naproxen

History of medication for the same complaint:

Tablet Advil (Ibuprofen)

#

Hi,

Welcome to icliniq.com.

I understand your concern.

Such a high tire ANA (antinuclear antibodies) with centromere positive and musculoskeletal and systemic complaints is usually associated with Sjogren's syndrome, MCTD (mixed connective tissue disease). Concerning your age, it is less likely, but you have an overlapping feature with other autoimmune diseases. So. I think currently, your disease is in a stage of undifferentiated CTD (connective tissue disease). It will flourish in the next few years to a specific category or maybe autoimmune polyendocrine syndrome. A full check-up is needed with a good rheumatologist and immunologist. Start therapy with low-dose steroids and immune-suppressive agents after consulting a rheumatologist. Screening for other diseases full blot panel is needed next year. Monitoring of disease activity is far more essential.

Thank you.


Was this answer helpful?

 | 

Same symptoms doesn’t mean you have the same problem. Consult a doctor now!



Related Questions:
Test for multiple query thread

Dear Doctor,I had an ACTH stimulation test today. Should one get any physical reaction when the ACTH is in? If one has a physical reaction, is that good or bad? Or do the people who do not get any reaction are the ones who get the bad results?   Read full

I have hypothyroidism after taking medicines for hyperthyroidism. What is going on?

Dear Doctor,I had an ACTH stimulation test today. Should one get any physical reaction when the ACTH is in? If one has a physical reaction, is that good or bad? Or do the people who do not get any reaction are the ones who get the bad results?   Read full

Do I have to take medicine for ankylosing spondylitis whole life?

Dear Doctor,I had an ACTH stimulation test today. Should one get any physical reaction when the ACTH is in? If one has a physical reaction, is that good or bad? Or do the people who do not get any reaction are the ones who get the bad results?   Read full

Also Read Answers From:

ideaComprehensive Medical Second Opinion.Submit your Case

Also Read


PCOS and Liver Problems
The hormonal imbalances in polycystic ovary syndrome could cause liver diseases. Read the article to know the relationship between these medical conditions.  Read more»
Inferior Alveolar Nerve Lateralization Technique
The inferior alveolar nerve lateralization technique is a surgical lateralization technique to reposition the nerve. Read the article to know more about this.  Read more»
COVID-19 and Ebola: Similarities and Differences
This article gives a comparison and broader overview of the outbreak of the two deadliest diseases that showed a greater incidence over the last two decades.  Read more»

Ask your health query to a doctor online?

Ask a Rheumatologist Now

* guaranteed answer within 4 hours.

Disclaimer: No content published on this website is intended to be a substitute for professional medical diagnosis, advice or treatment by a trained physician. Seek advice from your physician or other qualified healthcare providers with questions you may have regarding your symptoms and medical condition for a complete medical diagnosis. Do not delay or disregard seeking professional medical advice because of something you have read on this website. Read our Editorial Process to know how we create content for health articles and queries.