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Is my ANA titer high due to Hashimoto's thyroiditis?

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Patient's Query

Hi doctor,

I have had an autoimmune reaction for a year now. Symptoms include fatigue, joint and muscle pain, fever spikes (never above 100oF), 40 lbs weight gain in five months, trouble losing weight, swelling, random rashes, heart palpitations, brain fog, migraines, stomach aches, etc. I am currently going through the whole diagnosis process of an autoimmune disease. I have a positive ANA titer of 1:5120 with a homogenous pattern. We narrowed down most of my issues to Hashimoto's thyroiditis. However, I tested positive for centromere B antibody, Anti-thyroid peroxidase antibody, anti-cardiolipin antibody, and negative for lupus and celiac, smooth muscle antibody, and mitochondrial antibodies. My urea nitrogen (BUN) is low, and ALT is high. I was wondering what that means and if it is something I should worry about.
Answered by Dr. Sayan Mukherjee

Education:

MD

Professional Bio:

Dr. Sayan Mukherjee is a Consultant in General and Internal Medicine with a special interest in immunology, rheumatology, and COVID-related care. He focuses on comprehensive patient management, including general and ICU care, and is affiliated with international professional organizations in asthma, allergy, immunology, and autoimmune diseases.

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Hi,

Welcome to icliniq.com.

I understand your concern.

Such a high tire ANA (antinuclear antibodies) with centromere positive and musculoskeletal and systemic complaints is usually associated with Sjogren's syndrome, MCTD (mixed connective tissue disease). Concerning your age, it is less likely, but you have an overlapping feature with other autoimmune diseases. So. I think currently, your disease is in a stage of undifferentiated CTD (connective tissue disease). It will flourish in the next few years to a specific category or maybe autoimmune polyendocrine syndrome. A full check-up is needed with a good rheumatologist and immunologist. Start therapy with low-dose steroids and immune-suppressive agents after consulting a rheumatologist. Screening for other diseases full blot panel is needed next year. Monitoring of disease activity is far more essential.

Thank you.

Medically reviewed by Dr. Sneha Kannan
Published At August 27, 2020
Reviewed At August 25, 2025

Education:

MD

Professional Bio:

Dr. Sayan Mukherjee is a Consultant in General and Internal Medicine with a special interest in immunology, rheumatology, and COVID-related care. He focuses on comprehensive patient management, including general and ICU care, and is affiliated with international professional organizations in asthma, allergy, immunology, and autoimmune diseases.

This doctor is not available for online consultations on the platform anymore.

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Education:

BDS

Professional Bio:

Dr. Sneha Kannan is a skilled Dental Surgeon with expertise in providing general dental care, including scaling, fillings, and preventive treatments. She does oral surgery procedures such as extractions and minor surgical interventions. She does procedures in restorative dentistry, including crowns, bridges, and dentures. She is an expert in doing endodontic treatments such as root canal therapy. She is well-versed in doing procedures in cosmetic dentistry, including teeth whitening and smile correction. She can provide pediatric dental care for children’s oral health and preventive treatments. She promotes oral hygiene awareness and preventive dental practices.  

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Dr. Sayan Mukherjee
Dr. Sayan Mukherjee

Internal Medicine

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Education:

MD

Professional Bio:

Dr. Sayan Mukherjee is a Consultant in General and Internal Medicine with a special interest in immunology, rheumatology, and COVID-related care. He focuses on comprehensive patient management, including general and ICU care, and is affiliated with international professional organizations in asthma, allergy, immunology, and autoimmune diseases.

This doctor is not available for online consultations on the platform anymore.

Consult other doctors in the same speciality
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