Q. My fibromyalgia pain does not respond to any medication. Why?

Answered by
Dr. Anshul Varshney
and medically reviewed by Dr. Vinodhini. J
This is a premium question & answer published on Feb 28, 2020 and last reviewed on: Feb 29, 2020

Hello doctor,

I was diagnosed with fibromyalgia a few years ago. Over the past three years, it has gotten much worse. I take Lyrica two times a day and Tramadol as needed for the pain. I still have a great deal of pain every day. The Lyrica makes me feel like I cannot think straight and the Tramadol just does not work anymore. I was prescribed Cymbalta which I took for approximately two years. It did nothing for me either. It was after that I started taking Lyrica. I have been taking it now for about six months.

I recently saw my provider and he did some trigger point injections which do help in the areas injected. He told me he does not know what else to do for me. I just feel like there are no doctors that want to even try to help people with fibromyalgia. Especially those with which all the current medications do not work. I am terribly frustrated and very tired of being in pain every day. I never get a break from the pain anymore. What other treatments are out there now. Anything new that I may have not heard of? Any help would be greatly appreciated. I work full-time and I just do not want to be so miserable while doing it. Apart from Lyrica, and Tramadol I am also taking Estradiol, Progesterone, Levothyroxin, and Fluoxetine.



Welcome to

Fibromyalgia is a very frustrating condition, but with the help of the patient, a doctor can treat it. I have treated my patients with all the drugs you have mentioned by managing the doses, but I always ask my patients to do meditation that would help the most in this problem.

In your case, I would recommend you to take Lyrica (Pregabalin) at the dose of 50 mg in the night time, which would not affect your thinking process. You should also take Cymbalta at doses of 60 mg per day. Your doctor would adjust these doses according to the symptoms you have been getting as well as the side effect profile.

I hope this helps.

Investigations to be done:

TSH (thyroid-stimulating hormone).

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