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HomeAnswersPain MedicinefibromyalgiaPlease suggest best treatment for fibromyalgia.

My fibromyalgia pain does not respond to any medication. Why?

The following is an actual conversation between an iCliniq user and a doctor that has been reviewed and published as a Premium Q&A.

Medically reviewed by

Dr. Vinodhini J.

Published At February 28, 2020
Reviewed AtSeptember 15, 2023

Patient's Query

Hello doctor,

I was diagnosed with fibromyalgia a few years ago. Over the past three years, it has gotten much worse. I take Lyrica two times a day and Tramadol as needed for the pain. I still have a great deal of pain every day. The Lyrica makes me feel like I cannot think straight and the Tramadol just does not work anymore. I was prescribed Cymbalta which I took for approximately two years. It did nothing for me either. It was after that I started taking Lyrica. I have been taking it now for about six months. I recently saw my provider and he did some trigger point injections which do help in the areas injected. He told me he did not know what else to do for me. I just feel like there are no doctors that want to even try to help people with fibromyalgia. Especially those with which all the current medications do not work. I am terribly frustrated and very tired of being in pain every day. I never get a break from the pain anymore. What other treatments are out there now? Anything new that I may have not heard of? Any help would be greatly appreciated. I work full-time and I just do not want to be so miserable while doing it. Apart from Lyrica, and Tramadol I am also taking Estradiol, Progesterone, Levothyroxine, and Fluoxetine.


Welcome to icliniq.com.

Fibromyalgia is a very frustrating condition, but with the help of the patient, a doctor can treat it. I have treated my patients with all the drugs you have mentioned by managing the doses, but I always ask my patients to do meditation that would help the most in this problem. In your case, I would recommend you to take Lyrica (Pregabalin) at the dose of 50 mg in the night time, which would not affect your thinking process. You should also take Cymbalta at doses of 60 mg per day. Your doctor would adjust these doses according to the symptoms you have been getting as well as the side effect profile.

I hope this helps.

Investigations to be done

TSH (thyroid-stimulating hormone).

Same symptoms don't mean you have the same problem. Consult a doctor now!

Dr. Anshul Varshney
Dr. Anshul Varshney

Internal Medicine

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