Jak 2 Mutation

Jak2 mutation is an acquired somatic mutation occurring in patients with myeloproliferative cancer. They result in the production of activated Jak protein. They help in improving the survival of cells and increases the production of blood cells. Thus abnormal blood clots are formed. Jak2 inhibitors, chemotherapy, and stem cell transplantation help to cure this condition.

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If I quit smoking, will my RBC, hemoglobin, and PCV levels come back to normal?

Query: Hello doctor, I am suffering from hypertension since few years, and I am currently on medication Telmisartan. I am an alcoholic and smoker, and I smoke approximately 15 cigarettes a day for the last five years. My current CBC report suggests high RBC, hemoglobin, and PCV. Though it reduced slightly ...  Read Full »


Dr. Goswami Parth Rajendragiri

Answer: Hi, Welcome to icliniq.com. I have gone through your attached reports (attachment removed to protect patient identity). The diagnosis is polycythemia. Polycythemia can be secondary or primary. Secondary polycythemia occurs because of hypoxia, which activates the oxygen sensor and more erythropoi...  Read Full »

Why do I have high hemoglobin and hematocrit values?

Query: Hi doctor, I am a 31 year old female. I have a history of celiac disease and a past medical history of Hodgkin's lymphoma, a stage 2 cervical lymph node and tumors in my chest. I had a blood test last week which showed B12 and folic acid deficiency, raised hemoglobin of 161 and raised hematocrit of ...  Read Full »


Dr. Goswami Parth Rajendragiri

Answer: Hi, Welcome to icliniq.com. You are having celiac disease in which because of malabsorption vitamin B12 deficiency and folate deficiency can occur. This deficiency also can be developed if polycythemia present in which proliferation more. Here hemoglobin and HCT is high as per history. Hence ...  Read Full »

Why are my hemoglobin and hematocrit values high without any symptoms?

Query: Hello doctor, I underwent routine bloodwork during my regular gynecological checkup. It showed a hemoglobin of 16.4 g/dL and hematocrit of 47.3 %. All other laboratory values are normal, and I do not have any symptoms. I am currently on Norethindrone for birth control and Spironolactone 100 mg for ...  Read Full »


Dr. Mubashir Razzaq Khan

Answer: Hi, Welcome to icliniq.com. Elevated hemoglobin is seen in dehydration, smokers, people living at high altitudes, congestive cardiac failure, chronic obstructive pulmonary disease, erythropoietin secreting adenomas of the kidney, and rarely could be a part of primary polycythemia. I suggest you ru...  Read Full »

I have a high vitamin B12 value and a family history of the JAK2 mutation, blood disorders, and cancer. Kindly help.

Query: Hello doctor, I am a 54-year-old female. My vitamin B12 was 2000 this week. I do not take any supplements. I also have hypopituitarism, and I do not know if it is related. I have a strong genetic predisposition to develop JAK2 (Janus kinase) and blood disorders. I have lost five pounds in three week...  Read Full »


Dr. Singh Smrita

Answer: Hello, Welcome to icliniq.com. Increased vitamin B12 levels in the absence of supplementation can be seen in liver disease and myeloproliferative disorders like polycythemia vera. I suggest you have liver function tests and a hemogram done initially. If your liver function tests are normal and your ...  Read Full »

I have a high Hb value; can I donate blood?

Query: Hello doctor, I am 34 years old. I went to donate blood today. But, the hospital rejected me as my Hb value is 16.9. Is this level abnormally high? Do I need to get any tests done?  Read Full »


Dr. Goswami Parth Rajendragiri

Answer: Hello, Welcome to icliniq.com. Yes, your hemoglobin value is high and needs to be investigated. Let me know if your hematocrit values were checked. If it is high as well, the condition is polycythemia. The cause for polycythemia may be secondary to chronic hypoxia due to a chronic heart failure...  Read Full »

My wife has a JAK2 positive myeloproliferative neoplasm with thrombocytosis. What does it mean?

Query: Hi doctor, My wife has a JAK2 (Janus kinase 2) positive myeloproliferative neoplasm with thrombocytosis, likely essential thrombocytosis. What does that mean? Does she have cancer or not? I need a fast and accurate answer. Does this mean she has cancer or not? What is life expectancy? Is there any ...  Read Full »


Dr. Mubashir Razzaq Khan

Answer: Hi, Welcome to icliniq.com. I am a hematologist with 20 years of experience. I hope you and your family are doing well in this pandemic. JAK2 positive myeloproliferative neoplasms mean it is some cancer. JAK2 is a mutation in a gene that leads to unlimited production of platelets in your ca...  Read Full »

Does a positive JAK 2 test indicate malignancy?

Query: Hi doctor, May I please have your opinion about the downloaded pathology results taken during a hospital admission? A couple of years earlier, there was a firm diagnosis of JAK 2 overlap myeloproliferative or myelodysplastic disorder. In your view, do the pathology results indicate an acute transfo...  Read Full »


Dr. Mohite Aniket Balasaheb

Answer: Hi, Welcome to icliniq.com. I am sorry to say that the reports you have updated are, unfortunately, a document of COVID-19 (coronavirus disease 2019) information. Can you please give me more information about the same and send your detailed CBC (complete blood count) and marrow reports with JAK 2 ...  Read Full »

In what cases high platelet count is noticed?

Query: Hello doctor. I just had a CBC done where my platelet count was 498. My last one was 423 about a year ago. I have not been feeling well lately with a sore throat and swollen lymph nodes. I also had the second COVID vaccine two weeks ago, and I was told that it could be the cause of the swollen lymp...  Read Full »


Dr. Mubashir Razzaq Khan

Answer: Hi, Welcome to icliniq.com. Elevated platelets: Grade 1 thrombocytosis: platelets 550-649. Grade 2 thrombocytosis: platelets 650-749. Grade 3 thrombocytosis: platelets 750-849. Grade 4 thrombocytosis: platelets 850-1099. Grade 5 thrombocytosis: platelets 1100 or more. Elevated platelets are ...  Read Full »

Does the presence of JAK2 gene mutation automatically rule out CML?

Query: Hi doctor, My platelet has always been high in the range of 600 to 700 x 10"9/L. My other blood count is within the normal range as of today. Ten years ago, I had two BCR or ABL test (peripheral blood) to rule out CML; one test came back positive, the other negative. Which test should I believe? Th...  Read Full »


Dr. Goswami Parth Rajendragiri

Answer: Hello, Welcome to icliniq.com. I can understand your concern. Do not worry. I will try to answer all of your questions. Following is my answers and opinion to your questions. RT PCR (Reverse transcriptase-polymerase chain reaction) is a highly accurate test to check BCR ABL mutation to rule out...  Read Full »

I have increased RBC along with decreased MCV and MCH. What could be the reason?

Query: Hi doctor, If my complete blood count has high RBC value and low MCV and MCH values, what is the possible diagnosis for me?  Read Full »


Dr. Goswami Parth Rajendragiri

Answer: Hi, Welcome to icliniq.com. High RBC count is called polycythemia. If it is persistently high, then the cause should be evaluated. Respiratory causes like COPD (chronic obstructive pulmonary disease) and cardiac causes can lead to secondary polycythemia. Primary polycythemia is a myeloproliferative...  Read Full »

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