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Medical Conditions - Jak 2 Mutation

Jak2 mutation is an acquired somatic mutation occurring in patients with myeloproliferative cancer. They result in the production of activated Jak protein. They help in improving the survival of cells and increases the production of blood cells. Thus abnormal blood clots are formed. Jak2 inhibitors, chemotherapy, and stem cell transplantation help to cure this condition.

All jak 2-mutation Q&A

Is there any cure for JAK2 positive myeloproliferative neoplasm with thrombocytosis?

Hi, Welcome to icliniq.com. I hope you and your family are doing well during this pandemic. JAK2-positive myeloproliferative neoplasms mean it is some cancer.

Can affect the prognosis of essential thrombocytopenia?

Hello, Welcome to icliniq.com. Thank you for your query.

What does the blood report of a diabetic patient indicate?

Hello, Welcome to icliniq.com. I understand your concern. I have read the attached report of your brother (attachment removed to protect patient identity).

What are the reasons for high platelet count?

Hello, Welcome to icliniq.com. The platelet count is above the normal range. There are many reasons for such an elevated platelet count. It needs further investigations, including genetic tests.

Why does my eczema flare up despite regular treatment?

Hello, Welcome to icliniq.com. I understand your concern. I would like you to know that eczema is a chronic inflammatory condition.

Do my reports show a life-threatening blood cancer?

Hi, Welcome to icliniq.com. I am sorry to say that the reports you have updated are, unfortunately, a document of COVID-19 (coronavirus disease 2019) information.

How to deal with JAK2+ ET and an MTHFR defect?

Hi, Welcome to icliniq.com. After reviewing your history and detailed medical report, my opinion is that you need regular follow-up with your hematologist for ET (essential thrombocythemia).

I have a very high platelet count and JAK2 gene mutation. Does this rule out CML?

Hello, Welcome to icliniq.com. I can understand your concern. Do not worry. I will try to answer all of your questions. Following are my answers and opinion to your questions.

Should one rely on manual or analyzer method of CBC values?

Hello, Welcome to icliniq.com. I completely understand your concern. Let us discuss how to solve it. Please note that you have not mentioned which parameter you have measured.

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