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Medical Conditions - Jak 2 Mutation

Jak2 mutation is an acquired somatic mutation occurring in patients with myeloproliferative cancer. They result in the production of activated Jak protein. They help in improving the survival of cells and increases the production of blood cells. Thus abnormal blood clots are formed. Jak2 inhibitors, chemotherapy, and stem cell transplantation help to cure this condition.

All jak 2-mutation Q&A

Is it possible to have low erythropoietin count and high RBC count together?

Hello, Welcome to icliniq.com. Your hemogram and erythropoietin levels are normal. I would not evaluate you any further.

Can affect the prognosis of essential thrombocytopenia?

Hello, Welcome to icliniq.com. Thank you for your query.

Is there any cure for JAK2 positive myeloproliferative neoplasm with thrombocytosis?

Hi, Welcome to icliniq.com. I hope you and your family are doing well during this pandemic. JAK2-positive myeloproliferative neoplasms mean it is some cancer.

How does elevated vitamin B12 relate to JAK2 mutation and cancer?

Hello, Welcome to icliniq.com. Increased vitamin B12 levels in the absence of supplementation can be seen in liver disease and myeloproliferative disorders like polycythemia vera.

Answered By
Dr. Singh Smrita

Dr. Singh Smrita

What does polycythemia (JAK 2 negative) mean?

Hello, Welcome to icliniq.com.

What does the blood report of a diabetic patient indicate?

Hello, Welcome to icliniq.com. I understand your concern. I have read the attached report of your brother (attachment removed to protect patient identity).

What are the reasons for high platelet count?

Hello,Welcome to icliniq.com.The platelet count is above the normal range. There are many reasons for such an elevated platelet count. It needs further investigations, including genetic tests.

Why does my eczema flare up despite regular treatment?

Hello, Welcome to icliniq.com. I understand your concern. I would like you to know that eczema is a chronic inflammatory condition.

Do my reports show a life-threatening blood cancer?

Hi, Welcome to icliniq.com. I am sorry to say that the reports you have updated are, unfortunately, a document of COVID-19 (coronavirus disease 2019) information.

How to deal with JAK2+ ET and an MTHFR defect?

Hi, Welcome to icliniq.com. After reviewing your history and detailed medical report, my opinion is that you need regular follow-up with your hematologist for ET (essential thrombocythemia).

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