Q. Do you feel CMIA is better than ELISA?

Answered by
Dr. Prakash H Muddegowda
and medically reviewed by iCliniq medical review team.
Published on Nov 29, 2016

Hi doctor,

My CMIA on 177th day was nonreactive with an index of 1.4. My second CMIA on 181st day was also nonreactive with an index of 0.8. These two were done at different places. If you compare ELISA and CMIA combo for HIV antibody testing, which is better? What is the maximum window period of forming antibodies and what are the reasons behind the delay? If you compare rapid card test with CMIA, which is more sensitive and reliable? Based on my reports, can I consider it conclusively negative?

Dr. Prakash H Muddegowda

Geriatrics Hematology Pathology
#

Hi,

Welcome to icliniq.com.

Based on your query and attached reports (attachment removed to protect patient identity), my opinion is as follows:

  • CMIA combo - chemiluminescent microparticle immunoassay is better as it detects both antigens and antibodies, whereas, ELISA (enzyme-linked immunosorbent assay) mainly detects only antibodies.
  • The window period is usually around three months. Depressed immune system or malnutrition can delay or reduce the formation of antibodies. However, antigen will be present and CMIA combo should be positive, if infected.
  • Rapid card is an emergency test and it is not as sensitive or reliable as CMIA combo.
  • Yes, you can safely assume yourself as negative and further tests are not necessary.

For further doubts consult a pathologist online --> https://www.icliniq.com/ask-a-doctor-online/pathologist

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