Get E-Book on COVID-19

Q. My results showed positive for HSV-1, but I do not have any symptoms. Why?

Answered by
Dr. Sadaf Mustafa
and medically reviewed by Dr. Preetha J
This is a premium question & answer published on Oct 20, 2020

Hi doctor,

Two years back, I got STI testing and asked for all of the tests available. I am starting a new relationship and wanted to be thorough. The results showed positive for HSV type 1 (which I knew). I got cold sores when I was a kid and mildly positive for type 2. It was something I researched and learned about false positives with IgG and the Western blot test. I took the western blot test, and the results showed negative. I am starting a new relationship and so got tested again. Type 1 shows 37, and type 2 shows 5.0. It has been over six months since I have had any sexual contact with anyone. Could the 37 the type 1 be making the type 2 antibodies high? If I had type 2, it would have been from a contact at least six months ago. Would not the IgG be higher than 5.0? I never had any rashes or any genital symptoms. I have not had any cold sore in these years, either.

Dr. Sadaf Mustafa

General Medicine Internal Medicine
#

Hello,

Welcome to icliniq.com.

Usually, the herpes simplex virus stays dormant in your body and produces IgG antibodies, which indicate chronic infection or exposure. The IgM antibodies indicate more acute exposure or response. Under normal circumstances, HSV type 1 and type 2 make distinct antibodies, and we do not see cross reactivity. You had two positives and one negative test for HSV-2. This could be an old exposure; it could be months or even years old. These antibodies are prevalent. If it is feasible for your partner, he or she can get tested as well. That way, you will have peace of mind. This result does not necessarily mean that your exposure is recent. We can see false positives, which is why repeating the same test or a different method of looking for HSV-2. Usually, there has to be an underlying pathology to have false positives. Let me know if you have any other questions. Thank you.



Was this answer helpful?

 | 

Hi doctor,

Thank you for your answer.

One of my positive tests was less than 2.0, which have a high likelihood of being false. My second positive, which is two years later, is 5.00. Is it common for people who have had an infection for a long time to have only a 5.00 IgG? What could be an underlying pathology for the repeated false positives?

Dr. Sadaf Mustafa

General Medicine Internal Medicine
#

Hello,

Welcome back to icliniq.com.

Yes, you can see repeated elevated levels and the antibody titters could fluctuate. We usually think about autoimmune disorders if we are thinking of false positives but this is due to cross reactivity to other antigens, it is usually unlikely to have multiple false positive tests even if there is an underlying alternative etiology. If you can get the HSV-2 IgG inhibition assay more than once it should be able to distinguish between true and false positives. I hope it helps.


Was this answer helpful?

 | 

Related Questions:
HSV 1/ 2(IGG) type-spec AB tested positive. Am I contagious?
Would viral infection affect the lymphocyte and neutrophil values?
Can viral infection cause diarrhea in a baby?
Consult by PhoneConsult by Phone Video ChatVideo Chat
Also Read Answers From:

Comprehensive Medical Second Opinion.Submit your Case

Related Questions & Answers


Is there any relation between dark vaginal pigmentation and herpes?

Query: Hello doctor, I have two concerns. I have not had sex in over a month and I used a condom with a partner I have been on and off with over the last two years. I have never had any sores from him, and he never had a sore either. My concerns are: I have noticed this dark pigmentation in a few spots. ...  Read Full »

HSV IgM tested on tongue came negative. Need a second opinion. Is there any Suggestions?

Query: Hello doctor, My brother had one blood test with herpes simplex IgM diagnosed to be negative, but herpes type 1 was diagnosed to be positive with an index more than 8. Before that he did a test on his tongue and it was negative for herpes. Are these results final? Or is there a chance that he is n...  Read Full »

What kind of muscle pain is associated with ARS?

Query: Hi, I am a 31 year old male. About 38 days before I had sex with a CSW (Commercial Social Worker). It was protected vaginal sex and protected oral sex. Also there were deep throat kisses which lasted almost a minute. I am not sure if the condom was torn during the intercourse.  Since last 3 weeks ...  Read Full »

Also Read


Miscarriage
This article provides you with all the information that you should be knowing about miscarriage. Although this is an emo...  Read more»
COVID-19 Testing
COVID-19 testing includes analyzing patient samples to determine current or past infections with SARS-CoV-2. Read the ar...  Read more»
I feel a restlessness in my legs, which decreases my sleep quality. How to get a refreshing sleep?
Hello doctor, I cannot get refreshing sleep some days in a week, and some days it is good. I also have difficulty sleep...  Read more»

Ask your health query to a doctor online?

Ask a General Medicine Physician Now

* guaranteed answer within 4 hours.

Disclaimer: All health Q&As published on this website is not intended to be a substitute for professional medical diagnosis, advice or treatment by a trained physician. Seek the advice from your physician or other qualified health-care providers with questions you may have regarding your symptoms and medical condition for a complete medical diagnosis. Do not delay or disregard seeking professional medical advice because of something you have read on this website.