Why do I have diarrhea for a year despite of all the lab reports being normal?

Hello,

Welcome to icliniq.com.

I understand your concern.

You explained your symptoms very well, but I need some more information before guiding you correctly.

Diarrhea for one year can occur in many conditions, namely celiac, food allergy, worms, autoimmune, drugs, Crohn's disease, ulcerative colitis, pancreatitis, and functional diarrhea due to hypersensitive gut.

Kindly answer me the following to differentiate among various conditions.

1) Have you lost weight?

2) Do you have abdominal pain? If yes, what is the site of pain, relieving and aggravating factors, type of pain?

3) Do you have a fever?

4) Do you have nocturnal symptoms?

5) Have you done tests for pancreatic elastase?

6) Do you notice allergy to any food?

7) Have you been tested for celiac disease?

8) Did you undergo cross-sectional imaging such as a CT (computed tomography) scan of the abdomen?

Kindly let me know all the medications that you take, including any neuropsychiatric drugs. And upload the reports of the blood, stools, and imaging tests done so far.

All this will help me to guide you properly.

Regards.

Hi,

Welcome back to icliniq.com.

Thanks for providing further information regarding your symptoms.

It seems you have irritable bowel syndrome (IBS).

The criteria for IBS are;

1) Lower abdominal pain lasting for at least six months, and active in last three months.

2) Change in pain intensity with each bowel movement

3) No explainable reason for diarrhea.

4) No weight loss.

All investigations and no nocturnal symptoms favor the diagnosis of IBS.

Since you have a detailed workup for diarrhea already, there is still room for certain investigations such as celiac disease serology, blood testing to detect gluten allergy in the gut, and gastroscopy (the examination of the stomach and small bowel done with a flexible scope that goes down through your mouth under some form of sedation).

Let me suggest you some treatment, and see if that improves your symptoms.

Take tablet Rifaximin 200 mg thrice daily for 21 days. If not available over the counter, you can ask your physician to write down a prescription for the same.

Take tablet Mebeverine 135 mg thrice daily a half an hour before meals. This is an antispasmodic medication that will help control your pain and the consistency of the stools. It is available in the brand name of Colofac.

Avoid high FODMAP (fermentable oligosaccharides, disaccharides, monosaccharides, and polyols).

I hope this summarizes all the information that you need for now.

Kindly do the following blood tests to investigate further;

Anti tTG-IgA (Transglutaminase Immunoglobulin-A and Immunoglobulin-G, and serum Immunoglobulin-A levels).

After three weeks, I want to hear from you as I can modify the medicine, stop certain, and ask for others to be continued.

Thanks.