I have twitching and cramps in the muscles. Can this be amyotrophic lateral sclerosis?

Q. Why do I have twitching and cramps in my muscles all over my body?

Answered by
Dr. Hitesh Kumar
and medically reviewed by iCliniq medical review team.
This is a premium question & answer published on Mar 17, 2022

Hello doctor,

I am a 26-year-old female. About four years ago, I woke up one day and noticed that I had twitching in my thumb. It has progressed rapidly to every muscle in my body even places I did not know could twitch were twitching. It has not gotten any better. In fact, right now my right thumb is twitching, it never stops. I have a hard time sleeping because of it. It is annoying and scary and I cannot stop thinking I have amyotrophic lateral sclerosis. I have been doing strength tests multiple times a day lately and now my left arm feels heavy, tired and weak. I have also noticed that I have excessive saliva in my mouth constantly and a hard time swallowing food with it getting stuck in my throat. I am very anxious about it and have been telling myself that it will be fine. Please help me out.



Welcome to icliniq.com.

I would like to know some details about your symptoms:

1. Apart from twitching, do you have weakness or thinning of any muscles? Are these twitchings visible by eyes or only felt inside?

2. Do you have any sensory symptom like tingling, burning, pins and needles sensation? If yes, in which body parts?

3. Do you have any significant neck or lower back pain?

4. Do you have any difficulty in controlling urinary urge?

5. Have you ever consulted for these twitching and has any investigation been done? If yes, which all investigations? Has any diagnosis been made?

6. How is your common mood - happy, sad, or worried?

7. How is your sleep usually?

8. Do you have any associated medical condition or on any medications? If yes, please describe.

I advise you to get the following investigations done.

1. MRI (magnetic resonance imaging) of brain.

2. MRI of whole spine.

3. NCS (nerve conduction study) and EMG (electromyography) of all four limbs.

4. T3 (triiodothyronine), T4 (thyroxine), and TSH (thyroid-stimulating hormone).

5. Vitamin B12.

6. Vitamin D3.

7. Calcium.

8. Magnesium.

Revert with above-mentioned information for better understanding and further judgement.


Differential diagnosis:

1. Anxiety induced twitching.

2. Benign fasciculation syndrome.

3. Cramp-fasciculation syndrome.

4. Motor neuron disease.

Hello doctor,

I do not have any muscle weakness. I do strength tests multiple times a day and have had twitching all over my body for the last years. I have health anxiety. Sometimes, I get some muscle cramps. I am considering to see a doctor soon.



Welcome back to icliniq.com.

If there is no muscle weakness and no thinning of muscles in any part for the last four years, it seems less likely to be amyotrophic lateral sclerosis. The chances are more that it can be benign fasciculations or it can be anxiety induced. Still, I would suggest consulting a neurologist for detailed physical examination and investigations to rule out a few things. Also, I advise you to get a psychiatrist consultation to address the anxiety issue.

Was this answer helpful?


Same symptoms doesn’t mean you have the same problem. Consult a doctor now!

Related Questions:
I am a 40-year-old male with anxiety, and I started getting fasiculations throughout my body. Is it BFS or ALS?

Regarding your recent normal EMG (electromyography) result and neuro examination, I agree with your neurologist's diagnosis and assure you that it is BFS (benign fasciculation syndrome) ... After an intense struggle with withdrawal from an anti-depressant over three to four months, I started getting fasciculation throughout my body .   Read full

I have muscle twitching with tingling and balance problem. Is this ALS?

.. gone through the attached photo (attachment removed to protect patient identity). Your EMG (electromyography) is normal. We can exclude ALS (amyotrophic lateral sclerosis) in your case. It is necessary to do some investigations to rule out the possible cause.   Read full

I have muscle twitching after being diagnosed with H.pylori. Kindly help me.

.. your concern and would explain that the twitching could be related to different possible causes like inflammation, insomnia, straining physical activity, anxiety, thyroid gland dysfunction, Vitamin B12 and Vitamin D deficiency, peripheral neuropathy, etc.   Read full

Also Read Answers From:

ideaComprehensive Medical Second Opinion.Submit your Case

Also Read

PCOS and Liver Problems
The hormonal imbalances in polycystic ovary syndrome could cause liver diseases. Read the article to know the relationship between these medical conditions.  Read more»
Inferior Alveolar Nerve Lateralization Technique
The inferior alveolar nerve lateralization technique is a surgical lateralization technique to reposition the nerve. Read the article to know more about this.  Read more»
COVID-19 and Ebola: Similarities and Differences
This article gives a comparison and broader overview of the outbreak of the two deadliest diseases that showed a greater incidence over the last two decades.  Read more»

Ask your health query to a doctor online?

Ask a Neurologist Now

* guaranteed answer within 4 hours.

Disclaimer: No content published on this website is intended to be a substitute for professional medical diagnosis, advice or treatment by a trained physician. Seek advice from your physician or other qualified healthcare providers with questions you may have regarding your symptoms and medical condition for a complete medical diagnosis. Do not delay or disregard seeking professional medical advice because of something you have read on this website. Read our Editorial Process to know how we create content for health articles and queries.