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Q. Will irregular paleo diet result in low vitamin D and B12 levels?

Answered by
Dr. Vivek Pillai
and medically reviewed by Dr. Vinodhini. J
This is a premium question & answer published on Mar 18, 2020

Hi doctor,

This is for my husband. On Saturday, he had a master health check-up and a few values are not good. I would like to hear your opinion on those. He is 35 years old. His weight is 71.9 kg and height is 168 cm.

The abnormal values are as follows:

1) Serum globulin 4.2 gm/dl - High (normal range 2-3.5).

2) T4 - 11.46 ug/ml - High (normal 4.6 - 10.5) whereas T3 and TSH are normal.

3) Vitamin D - 9.65 (low).

4) Serum HDL 34.9 (low) other triglycerides and LDL values are normal.

5) Vitamin B12 - 144 (low) (normal 180-914).

Also, I attached his ECG where it was mentioned unconfirmed report. Please check and let me know the outcome of the report.

He is an athlete who is active in a cycling race, running and swimming. But, he was out of the sport for one year and hence gained weight around 75 kg from 68 kg. Now, again he reduced 4 kg in the last three months. But he is following bad diet plans such as paleo one week, intermittent for the next week, proper balanced normal food for one week. Hence, I am really worried about his health.

Dr. Vivek Pillai



Welcome to

I feel his low vitamin B12 levels may be linked to his paleo diet, which can be deficient in legumes, nuts (which are beneficial for the heart). He need not be so fastidious about the diet, I feel and vitamin B12 can be got from dairy products, eggs, fish, and chicken.

His low Vitmain D levels are almost very prevalent in Indians, and basically this can be rectified by more outdoor activity, and if need 60,000 units of D-rise once per week for six weeks.

His HDL levels are low and although his LDL (bad cholesterol levels) are also low, I would recommend daily exercise (half an hour daily) to boost HDL levels.

His isolated High T4 levels, mean you need to check for a thyroid goiter and possibly do a thyroid scan, but it could also be linked to high globulin levels. Isolated high globulins need work up too, possibly disorders of immunity or rare disease like multiple myeloma (possibly consult a hematologist).

I hope this helps.

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Thank you doctor,

Please comment on his low HDL and ECG.

Dr. Vivek Pillai



Welcome back to

His ECG is normal (attachment removed to protect patient identity). I already mentioned exercise as a method of increasing HDL even Niacin tablets are used, but I have no experience with them.

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