HomeAnswersEndocrinologypcosWhat is the recommended maximum dose of Spironolactone for PCOS?

My PCOS symptoms recurred even with Spironolactone. Why?

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The following is an actual conversation between an iCliniq user and a doctor that has been reviewed and published as a Premium Q&A.

Medically reviewed by

Dr. Vinodhini J.

Published At August 3, 2020
Reviewed AtJanuary 18, 2024

Patient's Query

Hello doctor,

I have PCOS whose symptoms are extremely effectively managed by both my oral contraceptive (Sprintec), and miracle drug Spironolactone, which I take 100 mg a day for. It has greatly lessened my period pain, cleared my skin, hirsutism, and kept my ovaries safe for around four years now. Now I have perfect skin and extremely regular periods, which I am very grateful for. After my period ended last week, within the past few days, all of my symptoms have suddenly returned, as if I never took the Spironolactone at all. I am afraid that either the medication randomly stopped working, or there is a deeper hormonal issue present that is overpowering its effects. I am also worried about the reproductive consequences of not taking care of this properly. My questions are have you ever heard of Spironolactone suddenly not working out of nowhere? What medications can I take instead of Spironolactone that can also target my PCOS and extreme hormonal cystic acne? If there seems to be another hormonal issue present, what blood work would you order?

Hello,

Welcome to icliniq.com.

I have gone through your query. Yes, sometimes, the dose of Spironolactone is not sufficient to suppress the androgens. So maximum you may take up to 100 mg twice a day. Even though if symptoms not improved you have to take Finasteride like anti-androgens under your doctor advice to decrease inflammatory acne and hirsutism. Also, check weight for increased or not.

Investigations to be done

Serum testosterone. Serum creatinine and electrolytes. Ultrasound abdomen and blood sugar levels.

Preventive measures

If you are pregnant please do not take Spironolactone. If your serum potassium is higher do not take Spironolactone.

Regarding follow up

Review with reports or consult with your gynecologist she will examine and treat you accordingly.

Same symptoms don't mean you have the same problem. Consult a doctor now!

Dr. Penchilaprasad Kandikattu
Dr. Penchilaprasad Kandikattu

Internal Medicine

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