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HomeAnswersEndocrinologypremature menopauseDo radiotherapy and chemotherapy cause menopause?

Can cancer treatment cause menopause and behavioral changes in a woman?

The following is an actual conversation between an iCliniq user and a doctor that has been reviewed and published as a Premium Q&A.

Answered by

Dr. Shaikh Sadaf

Medically reviewed by

iCliniq medical review team

Published At January 14, 2023
Reviewed AtOctober 13, 2023

Patient's Query

I was treated with radiotherapy and chemotherapy for rectal cancer more than one year ago. Therapy caused menopause. Later I experienced behavioral changes, aggression, and mood swings. When I checked hormones, estrogen was one pg/mL when the reference for menopausal women was up to 28. The other hormone is an antimullerian, which is 0.01 ng/mL versus 0.14-10.40 ng/mL reference. Also, anti - Tg is slightly high at 4.31 IU/ml, the reference being less than 4.11 IU/ml. The rest of the tested hormones -prolactine, LH, FSH, Anti-TPO, Testosterone, fT4, TSH, and fT3 are within normal range.

Kindly advise.

Answered by Dr. Shaikh Sadaf


Welcome to icliniq.com.

I just read your query, and from what you have mentioned, it appears that you have premature ovarian failure and the symptoms you are experiencing are due to menopause. This might be due to the chemotherapy and radiotherapy you had taken to treat your rectal carcinoma. Yes, your thyroglobulin antibodies are slightly raised but not that high as to cause thyroid dysfunction. Your thyroid is perfectly normal.

Hope you find my advice beneficial.

Thank you.

Same symptoms don't mean you have the same problem. Consult a doctor now!

Dr. Shaikh Sadaf
Dr. Shaikh Sadaf


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