I underwent radiotherapy and chemotherapy for rectal cancer, which has resulted in menopause and behavioral changes. Kindly help.

Q. Can cancer treatment cause menopause and behavioral changes in a woman?

Answered by
Dr. Shaikh Sadaf
and medically reviewed by iCliniq medical review team.
This is a premium question & answer published on Jan 14, 2023 and last reviewed on: Feb 08, 2023

I was treated with radiotherapy and chemotherapy for rectal cancer more than one year ago. Therapy caused menopause. Later I experienced behavioral changes, aggression, and mood swings. When I checked hormones, estrogen was one pg/mL when the reference for menopausal women was up to 28. The other hormone is an antimullerian, which is 0.01 ng/mL versus 0.14-10.40 ng/mL reference. Also, anti - Tg is slightly high at 4.31 IU/ml, the reference being less than 4.11 IU/ml. The rest of the tested hormones -prolactine, LH, FSH, Anti-TPO, Testosterone, fT4, TSH, and fT3 are within normal range.

Kindly advise.



Welcome to icliniq.com.

I just read your query, and from what you have mentioned, it appears that you have premature ovarian failure and the symptoms you are experiencing are due to menopause. This might be due to the chemotherapy and radiotherapy you had taken to treat your rectal carcinoma. Yes, your thyroglobulin antibodies are slightly raised but not that high as to cause thyroid dysfunction. Your thyroid is perfectly normal.

Hope you find my advice beneficial.

Thank you.

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