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HomeAnswersAllergy Specialistsore throatI am allergic to Penicillin. Is it safe to take Cefpodoxime?

Is Cefpodoxime safe for a person who had liver injury with Amoxicillin-Clavulanate?


The following is an actual conversation between an iCliniq user and a doctor that has been reviewed and published as a Premium Q&A.

Medically reviewed by

iCliniq medical review team

Published At March 12, 2018
Reviewed AtFebruary 18, 2024

Patient's Query

Hello doctor,

I am suffering from a painful sore throat and tonsillitis for two weeks. I am allergic to Penicillin and earlier had Amoxicillin-Clavulanate antibiotic-induced elevated SGOT and SGPT of the liver. With treatment, I fully recovered. Now, this time, the doctor prescribed Cefpodoxime instead of the Amoxicillin-Clavulanate combined antibiotic. Whether Cefpodoxime will be safe for a person like me who earlier suffered from Amoxicillin-Clavulanate-induced liver injury? I am badly suffering from strep throat. Please suggest.


Welcome to icliniq.com.

Cefpodoxime and Amoxicillin being different classes of drugs, will not cause an allergy if the other one causes. Cefpodoxime is safe in patients with liver injury, at least in moderate doses. For the throat problem, I would advise in addition to antibiotics, some good symptomatic treatment. That would include anti-inflammatory medicines, painkillers, mouth rinses, and supportive measures. Dietary advice is to avoid cold foods and liquids, smoke, dust, masala, spicy and oily foods. Take plenty of warm liquids, soft diet, warm water, etc.

Take multivitamin tablets till your condition improves. Anti-inflammatory medicines are Chymoral forte (Trypsin Chymotrypsin) or Disperzyme (Rutoside, Bromelain, and Trypsin) tablets. Mouth rinses like Tantum gargles (Benzydamine) diluted in water will be helpful. Any associated nose or ear symptoms will require additional measures. Do you suffer from allergy? Take rest and avoid going outside for two days. Do write back to me in case you need any more advice.

Patient's Query

Hello doctor,

Thank you for your suggestion.

I am basically allergic to dust. I am also allergic to Penicillin as I have already mentioned. I do suffer from allergic dry cough and strep throat during season changes. As I suffered from liver enzyme-related problems due to Penicillin, this time the doctor prescribed Cefpodoxime 200 (twice daily), along with Montelukast 5 plus Levocetirizine 10 (once daily), Paracetamol 500 (twice daily), and Enterogermina (two times daily). I was a little bit susceptible to Cefpodoxime due to an Amoxicillin-Clavulanate-induced problem on the last occasion. This is for your kind information and suggestion.


Welcome back to icliniq.com.

The doctors' medicines seem fine. However, I would add an anti-inflammatory such as Chymoral forte (Trypsin Chymotrypsin) and Tantum mouth rinses (Benzydamine). These two will hasten recovery. Other advice you follow. If you could take a picture of your open throat showing the posterior pharyngeal wall and send. It will be helpful in understanding the gravity of the problem. If the problem does not improve, we may have to do a culture swab of the throat and institute an appropriate antibiotic. Do revert back for further support. Hope you get well soon.

Same symptoms don't mean you have the same problem. Consult a doctor now!

Dr. Shyam Kalyan. N
Dr. Shyam Kalyan. N

Otolaryngology (E.N.T)

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