Do I need to take Arimidex to inhibit high E2 levels?

Q. Are enlarged prostate, loss of libido, and joint pains symptoms of high estrogen levels?

Answered by
Dr. Ashok Kumar
and medically reviewed by Dr. Vinodhini. J
This is a premium question & answer published on Feb 10, 2020 and last reviewed on: May 29, 2023

Hi doctor,

I am 30 years old. I just want check whether my T/E2 values are proper not because I am suffering from most of the symptoms of high estrogen levels like enlarged prostate, extreme fatigue, anxiety, muscle loss, belly side fat, loss of libido, knee and joint pains for more than 10 years. Around six months back, I got checkups for gastritis, there they said it is minor gastritis only and all readings are good including thyroid, but better to check for T/E2 and PSA levels as they see enlarged prostate. Do I need to take any medicines to inhibit E2 levels like Arimidex? Please check the readings. I have a testosterone value of 580 ng/dL, E2 of 43.6 pg/ml, prostate size of 33 cc, weight of 165.3 pounds, BMI of 25.9, height of 5'6" feet, visceral fat of 10.5 and body fat of 27.9.



Welcome to

I read your query and understand your concerns. First of all, I would like to inform you that your testosterone is completely normal but not estradiol. The maximum physiological level is 40 pg/ml and the level above this rings alarm bell and should be investigated.

The increased level of PSA (prostate-specific antigen) along with prostate enlargement indicates there is abnormal aromatization of sex hormones which could be due to simple overweight to sex steroid secreting tumors. Regarding the treatment, there is a definite need for treatment and Aromatase inhibitors could be the right choice for you. There are multiple options for this purpose including Arimidex.

I hope this helps.

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