HomeAnswersGeneral Medicineunprotected sexCan I start PEP medicines if I have a bleeding penis after unprotected sex?

What are the precautions to be followed after unprotected sex?

Share

The following is an actual conversation between an iCliniq user and a doctor that has been reviewed and published as a Premium Q&A.

Answered by

Dr. Nagaraj

Medically reviewed by

Dr. Lekshmipriya. B

Published At August 26, 2022
Reviewed AtJanuary 28, 2024

Patient's Query

Hello doctor,

Recently I had unprotected sex and had a cut on my penis, which bled. So due to fear, I started PEP (post-exposure prophylaxis) medicines after talking to a doctor. I performed all the tests and found that my cholesterol levels were high. I fear continuing the medication. What if I end up having some long-term side effects of this medicine? Anyways chances of getting HIV from a single exposure are low. What shall I do?

Answered by Dr. Nagaraj

Hello,

Welcome to icliniq.com.

I read your query and can understand your concern.

Before I suggest it, I would like to know a few things.

1. Was your partner a regular or commercial sex worker?

2. Did you use any protection like a condom?

3. When did you start taking post-exposure prophylaxis medication?

4. How long did you take post-exposure prophylaxis medication?

Kindly revert. Thank you and take care.

Patient's Query

Hello doctor,

Thank you for the reply.

I had sexual intercourse with a commercial sex worker four days before. I did not use a condom for protection. And I have been taking the medications for the past two days.

Answered by Dr. Nagaraj

Hello,

Welcome back to icliniq.com.

I consider it as intercourse with a stranger who has indulged in multiple sexual encounters with multiple partners, and we do not know the HIV (human immunodeficiency virus) status of the lady. As you did not use protection and bled, the risk is high. It is good that you started your PEP (post-exposure prophylaxis) within no time, and I suggest you continue for at least 30 days. Although you may have side effects like nausea, vomiting, fatigue, etc., they may not be significant considering the benefits. Drink plenty of water to keep yourself hydrated. A slight increase in cholesterol is of no concern. However, reduce your weight for general well-being. Once you complete your course of medicine, get the HIV tests done after consulting your doctor. Further courses will be decided based on the test results.

Having said all these, do not panic. Good that you consulted your doctor and started medicines at the earliest. That should prevent infection up to the extent of 80 %. Do not get involved in sexual encounters until you complete your treatment course and get negative reports. Always practice the use of protection, especially with strangers and commercial sex workers.

I hope this helps. Thank you and take Care.

Patient's Query

Hello doctor,

Thank you for the reply.

I am taking post-exposure prophylaxis medication regularly. I am just scared if something happens because of this long course of drugs. So please mention the risk-benefit ratio of taking the drugs. Because I came to know through the internet that the probability of HIV through vaginal sex is very low even if a person is HIV positive. And if I ask that sex worker to have an HIV test and it comes negative, then can I stop taking post-exposure prophylaxis medication? Also, I already have a weak liver as I have been taking alcohol, so will this medicine affect my liver?

Answered by Dr. Nagaraj

Hello,

Welcome back to icliniq.com.

You must be taking the medicines for a month, and you need not worry. And do not search internet, which will only scare you with unnecessary information. Although vaginal sex carriers have a lesser risk than sharing syringes, the risk is still there, and you cannot undermine it. And, decisions can be taken accordingly if you can get an HIV(human immunodeficiency virus) test done for the sex worker. I am not sure of the extent of damage to your liver due to alcohol, but still, considering the risk, the benefits are much more significant.

Considering your wife's health, do not indulge in sex with her until you are negative after 30 days. I am sure you are aware of the effects of alcohol on health. Kindly avoid or be within the limit. You will never know when it takes a toll on your health.

I hope this helps. Thank you and take care.

Patient's Query

Hello doctor,

Thank you for the reply.

So if the sex worker's HIV test is negative, can I stop taking the medicines? But what if she is recently infected with HIV and the test result comes positive?

She told me she also had unprotected sex last week and had taken a pill. I did intercourse hardly for two minutes though it bled due to a cut on my penis.

Answered by Dr. Nagaraj

Hello,

Welcome back to icliniq.com.

I read your query and can understand your concern.

If she is negative for human immunodeficiency virus by PCR (polymerase chain reaction) method, you can discontinue medications after consulting your doctor. In addition to the PCR method, antibodies should also be checked for her. This will help us know both her past and current infection status. The duration of sex does not matter. What matters is a mix of body fluids.

I hope this helps. Thank you and take care.

Patient's Query

Hello doctor.

Please list down the tests I should ask the sex worker to take. So if all tests are negative, I shall quit the medicines, right?

Answered by Dr. Nagaraj

Hello,

Welcome back to icliniq.com.

The tests are antibodies for HIV 1 and 2 and the p24 antigen assay. Once the reports are available, which may take 24 to 48 hrs, think of the next course.

Thank you and take care.

Patient's Query

Hello doctor,

The mentioned tests are available in the lab. Please suggest one to identify the past and current infected state.

  1. HIV 1 and 2 antibodies, screening test.
  2. HIV 1 RNA (ribonucleic acid) quantitative, real-time PCR (polymerase chain reaction) with CD 3 (cluster of differentiation 3), CD 4 (cluster of differentiation 4) or CD 8 (cluster of differentiation 8) (immune deficiency panel) markers.
  3. HIV 1 and 2 antibodies, western blot.
Answered by Dr. Nagaraj

Hello,

Welcome back to icliniq.com.

I suggest taking HIV (human immunodeficiency virus) antibodies and western blot.

Thank you and take care.

Patient's Query

Hello doctor,

Earlier you suggested PCR (polymerase chain reaction) test. What if she is recently affected? Can you suggest tests required for her past and current infection status?

Answered by Dr. Nagaraj

Hello,

Welcome back to icliniq.com.

Western blot is a molecular study that utilizes PCR (polymerase chain reaction) to detect viral proteins like p24. Antibodies are two types covered in tests like immunoglobulin G and M, indicating both present or previous infection. I hope this clarifies.

Thank you and take care.

Patient's Query

Hello doctor,

Thank you for the reply.

I came to know that risk of human immunodeficiency virus transmission is low due to vaginal intercourse. Is it because vaginal fluid having human immunodeficiency virus cannot enter men's bodies through the penis? Please specifically reply on this point. Or are there fewer chances for HIV-positive women to have HIV viruses inside the vagina? I need to know this because there was a cut on my penis, which blended during sex. If all tests of the sex worker are found negative for human immunodeficiency virus, can I rely on this test and leave the medications? Or sometimes, do laboratory values have mistakes?

Answered by Dr. Nagaraj

Hello,

Welcome back to icliniq.com.

The risk is always there when body fluids come in direct contact. It is more with anal intercourse than vaginal. The person infected with HIV carries the viruses in their body fluids, including vaginal secretions. The viral load is much lesser in saliva and breast milk. As those two tests are confirmatory, you should be assured if they turn out to be negative. Therefore, you may discontinue your medicines post consultation with your treating physician. Although errors may happen, it is rare. Unfortunately, you cannot rule out the errors completely. Sometimes you do not even know the error. I suggest you continue with the medicines regularly at the same time of the day until her results are available.

I hope this helps. Thank you and take care.

Patient's Query

Hello doctor,

Thank you for your reply.

I am continuing PEP medications and today I have done body tests. Please check the attached file as some values are increased for example eosinophils. Is there any point of concern?

Answered by Dr. Nagaraj

Hello,

Welcome back to icliniq.com.

I read your query and can understand your concern.

Compared to your earlier shared report (attachment removed to protect the patient's identity), most values were within normal limits. I could see that there is a slight increase in liver enzymes (SGOT and SGPT), cholesterol levels, and eosinophils. Note that all are known side effects of the medications you are taking. However, this is of no concern as of now. But you may want to repeat the tests especially to monitor the liver enzymes. You may repeat after 10 days to monitor the same. All these side effects come down post-treatment.

Hope this helps.

Take Care.

Patient's Query

Hello doctor,

Thank you for your reply.

Please see the reports which we received for the girl. Her first two reports are negative but the third report shows a value of 51. So is she infected with HIV and in her window period? In this case, shall I keep taking my PEP medicines?

Answered by Dr. Nagaraj

Hello,

Welcome back to icliniq.com.

I read your query and can understand your concern.

Antibodies reports may take some time after infection. It only helps us understand past infections. The other report talks about active infection. It is still not conclusive. We may have to repeat the tests after 3 to 4 weeks. However, continue your PEP (post-exposure prophylaxis).

Hope this helps.

Thanks and take care.

Patient's Query

Hello doctor,

Thank you for your reply.

Please check the third report. We have done an RNA PCR test whose value is 51.

Answered by Dr. Nagaraj

Hello,

Welcome back to icliniq.com.

I read your query and can understand your concern.

I have gone through the report (attachment removed to protect the patient's identity). Antibodies are negative. However negative antibody test does not altogether rule out infection. The usual window period with increasing accuracy is 3 weeks to 3 months. However, her PCR has detected some viral load. This should be interpreted cautiously. I suggest you discuss this with your doctor at length. Many times typing over such issues can be incomplete.

Hope this helps.

Thanks and take care.

Patient's Query

Hello doctor,

Thank you for the reply.

1. Earlier you said western blot is a molecular study that utilizes PCR to detect viral proteins like p24. So how is it possible that p24 is found negative in the western blot test but it is showing value 51 for HIV RNA by PCR?

2. Most important question: I had sex with this lady 14 days back and my penis bled that time. So I am quite scared. However, I checked on the internet and it says that another person cannot spread HIV if the viral load is 50. However, is it possible that this girl was HIV positive and she must have taken medicine last 10 days due to this now the viral load is 50? Or can I rest assured that her viral load at the time of unprotected sex was 50 only? Can medicine reduce viral load to such a level in just 10 days' time?

Answered by Dr. Nagaraj

Hello,

Welcome back to icliniq.com.

I read your query and can understand your concern.

1. Western blot is also an antibody test that mostly confirms test positive if earlier screening was done by the ELISA (enzyme-linked immunoassay) method. The viral load by PCR method is adapted when you really want to get pictures as early as possible.

2. Although a high viral load can increase the chances of spread, a low load can also do so. However, the risk is always there.

Hope this helps.

Thanks and take care.

Patient's Query

Hello doctor,

Thank you for the reply.

Please see my HIV 1 RNA report which came negative. This test was done after two weeks of my exposure with the girl having a viral load of 51 copies per ml. Now I am still continuing Thioday and 5 days are left to finish this.

1. What are my chances now with this negative PCR report? Can PEP give a negative PCR report?

2. Also see my liver function test reports where SGOT and SGPT levels increased a lot suddenly.

Answered by Dr. Nagaraj

Hello,

Welcome back to icliniq.com.

I read your query and can understand your concern.

Good to see the results. I would discontinue medications in such cases as you are negative after about three weeks of exposure to the virus and the girl is also negative. However, I suggest you discuss it with your doctor once before discontinuation. Regarding liver enzymes, it is expected and is of no concern as of now as they are still below five times the upper limit of normalcy. With the withdrawal of medicines, they should settle.

Hope this helps.

Take Care.

Patient's Query

Hello doctor,

Thank you for the reply.

Perhaps you did not see the reports well.

1) Please see the third report of the girl which is viral load by RNA. It is showing HIV copies 51. So it is possible she has acute HIV Infection, hence her other reports are negative.

2) I have taken HIV 1 RNA viral load report after two weeks of starting PEP (not 3rd week). Sometimes PEP medicines can give false negative results if on HIV medicine, right? So shall I stop PEP now?

Answered by Dr. Nagaraj

Hello,

Welcome back to icliniq.com.

I read your query and can understand your concern.

Can you please schedule a phone consultation with me today? Would like to discuss this with you in detail. This will alleviate your anxiety as well.

Thanks and take care.

Same symptoms don't mean you have the same problem. Consult a doctor now!

Dr. Nagaraj
Dr. Nagaraj

Diabetology

Community Banner Mobile
By subscribing, I agree to iCliniq's Terms & Privacy Policy.

Ask your health query to a doctor online

General Medicine

*guaranteed answer within 4 hours

Disclaimer: No content published on this website is intended to be a substitute for professional medical diagnosis, advice or treatment by a trained physician. Seek advice from your physician or other qualified healthcare providers with questions you may have regarding your symptoms and medical condition for a complete medical diagnosis. Do not delay or disregard seeking professional medical advice because of something you have read on this website. Read our Editorial Process to know how we create content for health articles and queries.

This website uses cookies to ensure you get the best experience on our website. iCliniq privacy policy