HomeHealth articlesleukemiaIn What Ways Do Leukemia, Anemia, and Hemophilia Intersect?

The Intersection of Anemia, Leukemia, and Hemophilia: An Overview

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The overlap of anemia, leukemia, and hemophilia presents a challenge in hematologic health, demanding precise diagnostic and therapeutic interventions.

Medically reviewed by

Dr. Abdul Aziz Khan

Published At February 16, 2024
Reviewed AtFebruary 28, 2024

Introduction:

Leukaemia and anemia are two blood-related disorders. There is no proof that leukemia can be brought on by anemia. Nonetheless, anemia is more common in leukemia patients. This might result from anemia or a decrease in red blood cells, which is brought on by leukemia, a type of blood cancer. Furthermore, anemia might result from certain leukemia treatments. Disorders about blood can impact any of the three primary components of blood:

  1. The oxygen that red blood cells bring to the body's tissues.

  2. White blood cells in the fight against illness.

  3. Platelets aid in the clotting of blood.

  4. Blood diseases can also impact plasma, which is the liquid component of blood.

Different treatments and prognoses exist depending on the type of blood disorder and its severity.

What Are the Blood Conditions That Impact Red Blood Cells?

Red blood cell-affecting blood diseases include:

Anemia: Low red blood cell counts characterize anemia sufferers. Often, mild anemia has no symptoms. Exertion-induced exhaustion, pale complexion, and dyspnea are symptoms of more severe anemia.

Iron Anemia: The body needs iron to produce red blood cells. The most frequent causes of iron-deficiency anemia are low iron intake and blood loss after menstruation. Blood loss from the GI tract due to cancer or ulcers may also be the reason. Blood transfusions or iron tablets are occasionally used as treatments.

Chronic Disease-Related Anemia: Anemia is frequently developed by people with long-term kidney disease or other chronic illnesses. Chronic disease-related anemia typically responds well to no therapy; for certain patients with this kind of anemia, blood transfusions or injections of the synthetic hormone epoetin alfa may be required to increase the generation of red blood cells.

Pernicious Anemia:

A disorder when the body cannot absorb enough B12 from the diet is known as pernicious anemia (B12 insufficiency). An autoimmune disease or a compromised stomach lining may cause decrease absorption of vitamin B12. In addition to anemia, neuropathy (damage to the nerves) may later follow. High B12 dosages shield against long-term issues.

Aplastic Anemia: Individuals suffering from aplastic anemia experience insufficient production of red blood cells by their bone marrow. This can be brought on by a variety of illnesses, such as HIV, Epstein-Barr, or hepatitis, as well as drug side effects, chemotherapy, and pregnancy. Aplastic anemia may need to be treated with blood transfusions, medications, or possibly a bone marrow transplant.

A hyperactive immune system damages the body's red blood cells in individuals with autoimmune hemolytic anemia, resulting in anemia. Immune system suppressants like prednisone can be needed to halt the progression.

Can Leukemia Develop From Anemia?

One kind of cancer that can affect bone marrow and blood cells is called leukemia. Even though it is not a type of cancer, anemia can nevertheless impact the blood. Anemia is when a person's blood contains fewer red blood cells than it should.

The rapid generation of abnormal white blood cells is a common sign of the many kinds of leukemia. These cells hinder the bone marrow's capacity to create healthy cells like red blood cells and cannot combat infection. Anemia may arise from this. On the other hand, there is currently no proof that anemia and leukemia can coexist. Leukemia and anemia do, however, have further connections.

Can Anemia Result From Leukemia Treatments?

Anemia can result from various leukemia treatments, including chemotherapy and radiation therapy, according to the American Cancer Society (ACS). For instance, low red blood cell counts are frequently reported as a side effect. A dependable source for a variety of leukemia therapies, especially for those in need of high-dose therapy.

What Are the Similarities and Differences in Leukemia and Anemia?

Despite their vast differences, anemia and leukemia have one thing in common: they impact the blood. However, leukemia involves uncontrolled cell development, just like cancer. On the other hand, anemia is the absence of red blood cells. Nevertheless, leukemia is still a risk factor.

Leukemia may manifest in any of the following ways.

Leukemia: Acute vs. Chronic

When younger, less developed cells are affected, a person has acute leukemia. Conversely, older cells are affected by chronic leukemia. These older cells are more mature, yet they are still greatly affected by the disease. Furthermore, acute leukemias advance swiftly, but chronic leukemias typically evolve more slowly.

Lymphocytic versus Myeloid Leukemia

This is a reference to the impact on various blood cell types. When cancer targets lymphocytes, which are white blood cells, the patient has lymphocytic leukemia, rather than affecting lymphocytes, red blood cells, or platelets, myeloid leukemia attacks white blood cells.

Hyperproliferative Anemia

When a person's red blood cells are lost or damaged too quickly, they get this type of anemia.

Hypoproliferative Anemia

When a person's bone marrow does not create enough red blood cells, they have anemia.

Because leukemia starts in the bone marrow, hyperproliferative leukemia may result.

What Are Treatment?

Depending on the underlying causes, treatment options exist for both leukemia and anemia. The standard treatment for iron deficiency anemia involves altering one's diet or taking supplements to increase the body's red blood cell count.

Typically, chemotherapy, radiation therapy, or other more advanced forms of immunotherapy are used to treat acute forms of leukemia, such as acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML), to eradicate malignant cells. To replace the damaged bone marrow cells with healthy ones, a bone marrow transplant may be advised in certain circumstances. However, depending on several variables, treatments for chronic leukemias, such as chronic lymphocytic leukemia (CLL) and chronic myeloid leukemia (CML), may involve immunotherapy, chemotherapy, and targeted therapy.

Conclusion:

Anemia and leukemia prognoses are influenced by several variables, such as the severity of the illness and the promptness with which treatment is undertaken. Reducing symptoms and improving results require early diagnosis and treatment. For those who are worried about the signs or the treatment plan, speak to a physician.

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Dr. Abdul Aziz Khan
Dr. Abdul Aziz Khan

Medical oncology

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