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Osseointegration: Science Behind Dental Implant Fusion

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Read the article to learn about the current concepts, mechanism, and significance of osseointegration and biologic seal for a dental implant to be successful.

Medically reviewed by

Dr. Sowmiya D

Published At May 4, 2022
Reviewed AtAugust 2, 2023

What Is Osseointegration?

You may have heard your implant dentist use the word integration or fusion while discussing your options for using a dental implant to restore a missing tooth or teeth. The most crucial step in restoring or replacing a missing tooth or multiple teeth by implants is the osseointegrating ability of the dental implant to the underlying jaw bone. The science of osseointegration has not only widened the scope of treatment options for edentulous patients, but their consequences directly affect the general systemic health of the patient.

Osseointegration as a concept was first introduced and elaborated by professor Per-Ingvar Branemark (1969), (professor at the Institute of Applied Biotechnology, University of Goteborg). He defined this mechanism of osseointegration of an implant as "A direct structural and functional connection between living bone and the surface of the load-covering implant."

What Are the Current Concepts Surrounding Osseointegration?

In the last few decades, the dental profession, including general dentists and prosthodontists, has demonstrated different techniques and methods to compensate for tooth loss ranging from conventional crowns and bridges to removable or fixed partial dentures. However, an implant scores higher in terms of chewing efficiency and long-term restoration of oral health. The current acceptance of osseointegration is when there is no progressively related movement between the implant and the bone with which it is in direct contact, i.e., it is fixed or anchored and has undergone stable fusion with the jaw bone. Although the term was initially used only with respect to titanium metallic implants, the concept is currently applied to almost all current and previously used biomaterials that do possess the ability to osseointegrate.

Recent evidence suggests that coated implants display more osteoinductive properties compared to uncoated implants that demonstrated only more osteoconductive characteristics. Also, the coagulation-related proteins that attach predominantly to the titanium surface alongside the material's surface properties are shown to impact the regenerative process of the affected tissue.

What Is the Physiological Mechanism of Integration?

The main objective of developing recent biomaterials for any dental application is to improve the quality of osseointegration and considerably shorten the time needed to achieve integration. The designing of implants involves changes in the surface characteristics to obtain a good cellular response in the physiologic environment. Incorporating osteoinductive elements more than osteoconductive elements is heralded by most implantologists as the best measure to achieve primary bone healing. Initially, blood is present only between the implant fixture and bone. However, then a blood clot forms. The blood clot is then transformed by phagocytic cells, such as polymorphonuclear leukocytes, lymphoid cells, macrophages, etc. Occlusal stresses also help in stimulating the surrounding bone. As remodeling occurs, the osseointegrated fixtures can now withstand the tension of masticatory force or stress. The mechanism of osseointegration could be unpredictably affected by a pathological process that would not only cause inflammatory reactions in soft tissue (peri-mucositis) but a subsequent bone loss around an osseointegrated implant (periimplantitis).

As a disease of the current era that correlates to long term implant failure, peri-implantitis is defined as mainly a pathological condition characterized by clinical signs of inflammation such as bleeding on probing (BOP) with or without suppuration, increase in peri-implant probing depths (PPD), and clinical attachment loss (CAL) that would be accomplished alongside radiographic bone loss with plaque accumulation. In the three to six-month period of fusion between the implant and bone, the networks of collagen bundles surround the osteocyte cells and get inserted into glycoprotein layers. Research indicates that approximately a 100 Angstrom glycoprotein layer may be formed due to bone-implant contact. In addition, the Haversian bone also becomes well organized during this phase and forms osteon units.

What Is the Significance of an Implant Seal or Biologic Seal?

Current implant dentists have now recognized that for implants to be successful and survive for the long term in the otherwise hostile environment of the oral cavity, there has to be a productive biologic seal between the implant material and the jaw tissue or bone. Weinmann theorized the concept of a biological seal around implants. More recently, Lavelle also emphasized the necessity for the attached gingiva to adapt to the integrated implant to provide a barrier against bacterial ingress and oral toxins into the space between implant posts and biologic tissues. Dental implants classified based on structure and their bond contact, be it endosteal, transosteal, or subperiosteal, must still possess a superstructure or coronal portion usually supported by a post. This post must pass through the submucosal layer and the covering squamous epithelium into the gingival portion of the oral cavity. This is also known as permucosal passage created between the prosthetic part or the attachment and the bony support of the implant.

This permucosal zone is where initial tissue breaks down when the biological seal is affected. It begins as tissue breakdown and eventually causes tissue necrosis and destroys the soft tissue or seal around the implant. The biologic seal is vital in preventing peri-implantitis or implant infections as it remains a pivotal factor in dental implant longevity. A proper seal serves as a physiologic barrier that would be effective against the potential ingress of toxins, bacterial plaque, or oral debris. Still, it can also be protective against any other harmful substances that contact the implant in the oral cavity. The foreign body agents, known initiators of tissue and cell injury, must be prevented from entering the typical physiologic environment for bone stabilization. Only that can be responsible for the implant to fuse successfully.

Conclusion

Hence, the knowledge or understanding of implant prosthesis has evolved over the last few decades from just an experimental and laboratory-based field into an evidence-based clinical practice for which the most crucial phenomenon of implant success remains "Osseointegration."

Frequently Asked Questions

1.

What Is the Time Required for the Implant to Osseointegrate With the Bone?

Osseointegration involves the fusing of alveolar bone with the implant body by continuous bone apposition and remodeling in the area of the implant and becoming a natural part of the mouth. The successful completion of this process can take anywhere between three to six months after the placement of dental implants.

2.

How to Speed Up Osseointegration?

- Applying Ice Pack - After implant placement, the patient may experience pain and swelling. This may be relieved by applying an ice pack in the region of implant placement.
- Take Medications on Time - Taking medications on time may help to accelerate the healing process of dental implants. Antibiotics and painkillers can be given after implant placement to relieve swelling and inflammation. 
- Avoid Smoking - Smoking may result in harmful consequences to dental and overall health. Research states that failure of implant placement is higher in smokers than non-smokers. Tobacco products contain nicotine, which may reduce oxygen flow and make it harder for the body to heal it. Avoiding smoking is a better option for speeding up the healing process.
- Saltwater Rinses - Saltwater rinses help to soothe and reduce oral bacteria in the implant site. It is recommended that salt water rinsing four times a day can speed up the healing process.

3.

What Causes Failure of Osseointegration?

Several factors may affect the osseointegration process (fusing the bone into an implant), leading to failure. The possible causes include:
- Improper Position - The implant may become misaligned when it is placed in the wrong position in the bone, which is not ideal and results in the failure of osseointegration.
- Infections - Infections like peri implantation may cause implant failure. Infection may affect poor oral hygiene and affect the bone, gum, and other soft tissues, which may lead to bone loss.
- Failure of Osseointegration - Insufficient bone and other factors may affect the fusing of the implant with the bone, resulting in failure.
- Nerve Damage - The implant is positioned too close to any nerves and can affect the osseointegration process leading to failure.

4.

What Best Describes Osseointegration?

Osseointegration is defined as the process of interaction of alveolar bone and the implant without intervening soft tissue and melding to become a natural part of the mouth. The endosteal implant contains pores that help in the migration of osteoblasts and other supporting connective tissues. The approximate healing period of the implant is three to six months.

5.

What Are the Factors Affecting Osseointegration?

The key factors for successful implant osseointegration include:
- Implant material.
- Type of bone and its density used for the implant.
- Bone quantity - The amount of bone surrounding the implant. 
- Surgical technique.
- Healing time.
- Amount of heat generated during the procedure.
- The medical condition of the patient.

6.

Why Is Osseointegration Important for Dental Implants?

Osseointegration, which is considered a requirement for implant loading and the long-term clinical success of endosseous dental implants, is essential for implant stability. It is defined as the functional and structural connection between living alveolar bone and the surface of a carrying implant.

7.

What Material Is Used In Osseointegration?

Titanium and titanium coated with calcium phosphate derivatives are frequently used for medical and dental implant devices such as artificial joints, bone fixators, and dental implants. Titanium exhibits the properties of great corrosion resistance and good hard-tissue compatibility (bone formation and bone-bonding ability). Studies show that using titanium coating materials for implants may help to speed up the osseointegration process.

8.

Can an Osseointegrated Implant Be Removed?

Yes, a dental implant can be taken out of a patient's mouth. Complications, including implant breakage, incorrectly oriented or misplaced implants, and peri-implantitis, are reasons to remove the implant. An osseointegrated implant may need to be removed in order to manage these issues. An implant driver or any other forceps with a particular technique can be used for implant removal.

9.

Can One Feel Osseointegration?

Osseointegration is the process of fusing a bone with a dental implant. Patients can sometimes experience a strange feeling like something in their mouth while chewing with a newly placed dental restoration. Also, sometimes patients may feel mild irritation or discomfort because of healing.

10.

What Is the Success Rate of Osseointegration?

The overall success rate of successful implant placement is 98 percent.  The success rate for implants placed in the anterior maxilla ranges from 95.52 percent and 98.9 percent in the posterior mandible. About one percent of dental implants were also reported.

11.

What Happens if Osseointegration Fails?

Failure of osseointegration may affect the stability of dental implants. Osseointegration is considered as a requirement for implant loading and the long-term clinical success of endosseous dental implants. It is defined as the process of functional and structural connection between living alveolar bone and the surface of a carrying implant.

12.

What Location Has the Greatest Success of Osseointegration?

Studies state that the success rate for implants placed in the anterior maxilla ranges from 95.52 percent and 98.9 percent in the posterior mandible.

13.

Is Osseointegration Permanent?

Bone fusion with a metal implant is known as osseointegration. An artificial implant is surgically anchored and incorporated into bone, where it becomes permanently integrated.
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Dr. Achanta Krishna Swaroop
Dr. Achanta Krishna Swaroop

Dentistry

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