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Clotrimazole - Uses, Dosage, Side Effects, Drug Warnings, and Precautions.

Published on Feb 28, 2022 and last reviewed on Mar 17, 2022   -  7 min read


Vaginal and topical Clotrimazole applications treat fungal infections in the mouth and vagina. Learn about its uses, dosage, drug warnings, side effects, precautions, drug interactions, and more.


What Is Clotrimazole?

Clotrimazole is an antifungal drug used to treat fungal skin infections such as burning, itching, cracking, and discharge. It kills fungi by destroying the fungal cell membrane.

Topical Clotrimazole is described as pregnancy category B, and Clotrimazole vaginal is intended to be used in the vagina to treat vaginal yeast or candida infections. Clotrimazole vagina may also be used for purposes not listed in this medication guide. Usually, small amounts of Clotrimazole can be absorbed systemically following topical and vaginal administration. But still, topical Clotrimazole is considered a safe treatment for yeast infections in pregnant women and is a safer alternative to other antifungals.


Clotrimazole is an antifungal medication sold under the brand name Lotrimin. It can treat vaginal yeast infections, diaper rash, oral thrush, pityriasis versicolor, and types of ringworm, including athlete's foot and jock itch. It can be taken by oral route or applied as a cream. This medication is an azole antifungal. It works by inhibiting the growth of the yeast that causes the infection. The vaginal product comes in two forms: a vaginal cream or a tablet. Some products come in a skin cream form to be applied around the outside of the vagina. Consult your doctor before using this medication in case of self-treatment if this is your first vaginal infection. This medication will work only for vaginal fungal infections. For a different type of infection like bacterial vaginosis, you may need another medication. Do not use this medicine if there is fever, chills, flu-like symptoms, stomach or abdominal pain, or a bad-smelling vaginal discharge. Contact your doctor right away because these may be signs of a more severe infection.

What Are the Uses of Clotrimazole?

This medication helps treat the below-provided problems:

How Does This Work?

Clotrimazole has both fungistatic and fungicidal actions. Fungistatic action is when the organism's growth is inhibited, and in fungicidal action, the fungi are killed. This drug carries out its activity by binding with the phospholipid in the fungal cell membrane and altering its permeability.

How to Use?



What Should Be Avoided Before Taking Clotrimazole Vaginal?

What Are the Side Effects of Clotrimazole?

The side effects of Clotrimazole can be burning, swelling, redness, stinging, irritation, pimple-like bumps, tenderness, or flaking of the skin. When these effects persist or worsen, inform your doctor or pharmacist immediately. And if your doctor has instructed you to use this medication, understand that the benefit is greater than the risk of side effects of this drug. Many people do not have serious side effects after using this medicine but tell your doctor right away if there are any symptoms. Even though severe side effects like blistering, oozing, and open sores are unlikely, seek immediate medical attention if it occurs. The oil in the Clotrimazole creams and suppositories can weaken the latex condoms and diaphragms. The topical formulations used externally should be discontinued if irritation or sensitivity develops at the administration site. Symptoms of a severe allergic reaction can be:

Even if you notice other effects not listed above, you can contact your doctor or pharmacist.

What Are the Warnings and Precautions of Clotrimazole?

What Are the Interactions of Clotrimazole?

There are no known drug interactions with the topical Clotrimazole, but there are multiple interactions with oral Clotrimazole as the medication is a CYP450 enzyme inhibitor, primarily CYP3A4. Thus, any drug metabolized by the CYP3A4 enzyme will potentially be elevated when oral Clotrimazole is used. Therefore, the physician should be aware of the drugs the patient is taking before starting oral Clotrimazole. Certain medications should not be taken along with oral Clotrimazole.


Alcohol’s interaction with Clotrimazole remains unknown. Consult with your physician to know whether you can drink alcohol while on medication.

Lab Test:

Information not available.


Amphotericin B is the only drug known to interact with topical or vaginal Clotrimazole. Avoid Clotrimazole if you are already consuming Amphotericin B.


There is no information available regarding the interaction of this drug with any foods. Consult your physician to know more.


This medicine should be used with caution in people suffering from immunodeficiency syndromes like HIV and AIDS. This is because there is no adequate research on the drug's efficacy on these people.

What Are the Dosage Forms of Clotrimazole Vaginal?

The following are a few dosage forms of Clotrimazole vaginal:

osage forms of Clotrimazole vaginal

What Are the Dosage Guide for Clotrimazole Topical?

Dosage Guide for Clotrimazole Topical


Missed Dose:

If you miss a dose, use it as soon as you remember. However, skip the missed dose if it is near the time for the next dose. Instead, use your next dose at the regular time. Do not double the amount to catch up for the missed dose.


What Are the Common Brand Names of Clotrimazole?

Clotrimazole Topical:

Clotrimazole Vaginal:


Last reviewed at:
17 Mar 2022  -  7 min read




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