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Internuclear Ophthalmoplegia - Causes, Diagnosis, and Treatment

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Internuclear ophthalmoplegia is an eye disorder that affects the ability of the eyes to move together when looking to the side. Read about the topic in detail.

Medically reviewed by

Dr. Asha Juliet Barboza

Published At April 13, 2023
Reviewed AtApril 18, 2023

Introduction

The eyes are the sensory organs of the human body and are moved by six pairs of muscles. Smooth pursuit, vergence shifts, and saccades are three types of voluntary eye movements that primates and many other vertebrates utilize to track objects of interest. Internuclear ophthalmoplegia is an eye movement disease in which there is an inability to move both eyes to one side of the face equally. It is caused by the damage of a group of nerve fiber cells (medial longitudinal fasciculus) that attach to the brain. This disease can affect one or both eyes, but they can raise and lower their eyes, not inward. Internuclear ophthalmoplegia is frequently seen in older and younger individuals. Patients may also experience nystagmus (rapid involuntary motion) and blurry or double visions.

What Are the Causes of Internuclear Ophthalmoplegia?

Internuclear ophthalmoplegia is caused by the damage of a group of nerve fiber cells (medial longitudinal fasciculus) that attach to the brain. Although various medical conditions also contribute to this disease, it includes:

  • Stroke - A stroke (ischemia) occurs when the brain's blood flow is interrupted or diminished. A stroke usually affects only one eye and is mainly seen in older individuals.

  • Multiple Sclerosis - A neurological condition that affects nerve fiber protection sheaths (myelin) that disrupts brain to body connection. Multiple sclerosis usually affects both eyes and is mainly seen in young persons.

Other medical conditions include:

  • Encephalitis (a severe brain inflammation caused by viral infections).

  • Behcet's syndrome (a rare disease that causes blood vessel inflammation).

  • Hemorrhage.

  • Brain injury.

  • Cancer.

  • Lyme disease.

  • Medications.

What Are the Types of Internuclear Ophthalmoplegia?

Internuclear ophthalmoplegia is mainly classified into three types:

  • Unilateral - The disease affects only a single eye

  • Bilateral - The disease affects both eyes

  • Wall-eyed Bilateral (Webino) - Bilateral form when both eyes are turned outward.

Doctors have also differentiated between anterior (front) and posterior (back) forms of internuclear ophthalmoplegia. The location of the nerve injury in the brain was considered to be reflected by specific symptoms. However, fewer people are using this system. According to magnetic resonance imaging scans, the classification is unreliable.

What Are the Symptoms of Internuclear Ophthalmoplegia?

The symptoms of internuclear ophthalmoplegia include:

  • Dizziness.

  • The difficulty of moving the affected eye toward the nose.

  • Blurry vision.

  • Seeing double (diplopia).

  • Uncontrollable blinking or fluttering of the eye.

  • Involuntary back-and-forth sideways motion (nystagmus).

What Are the Risk Factors for Internuclear Ophthalmoplegia?

The risk factor for internuclear ophthalmoplegia includes:

  • Stroke.

  • Head injury.

  • Behcet's syndrome (a rare disease that causes blood vessel inflammation).

  • Guillain-Barré syndrome is when the nerves in a person's body are harmed by their immune system.

  • Brain tumors.

  • Encephalitis.

What Are the Diagnostic Tests for Internuclear Ophthalmoplegia?

1. Physical Examination - A physical examination can frequently diagnose internuclear ophthalmoplegia. The doctor will obtain a medical history and carefully examine the movements of the eyes. Some testing may not be necessary to confirm the diagnosis of internuclear ophthalmoplegia because the symptoms are so apparent. For example, the doctor will instruct the patient to concentrate on their nose before quickly shifting their attention to a finger held out to the side and examined for abducted eye back and forth movement.

2. Digital Imaging Tests - In some circumstances, the doctor will advise a computed tomography or magnetic resonance imaging scan to understand more about the exact cause of the condition. A magnetic resonance imaging examination of the medial longitudinal fasciculus nerve fiber may reveal some apparent injury.

3. Examinations of the Blood and Cerebrospinal Fluid (Csf) - These examinations may be used to find unusual internuclear ophthalmoplegia causes.

What Are the Treatment Options Available for Internuclear Ophthalmoplegia?

Depending on the underlying condition that caused it, the treatment for internuclear ophthalmoplegia will vary. For example, a person with multiple sclerosis must treat the progression of the disease and multiple sclerosis attacks. Daily medicines, injectable medications, physical therapy, infusions, and techniques for controlling pain are the management methods for these diseases.

The recovery from a stroke varies significantly from person to person. An infarction, like a stroke, is the cause of approximately one-third of all internuclear ophthalmoplegia cases. Reduce the risk of stroke by maintaining a healthy diet and exercising frequently. Additionally, it depends on the type of stroke and overall medical health. If someone suffers from internuclear ophthalmoplegia from an infection, an accident or medication will show complete recovery. Suggested treatment methods could include:

1. Botox Injection - A botox injection may be suggested by the doctor to treat misaligned eyes.

2. Fresnel Prism - Fresnel prism is an adhesive thin plastic film that attaches to the back of eyeglasses. The doctors may use a fresnel prism to correct double vision (diplopia).

3. Surgery - The doctor may advise surgery to correct the crossed eye (strabismus) for patients with a severe variant known as eye-walled bilateral (webino).

Physicians will likely perform more tests even after the treatment.

Conclusion

Internuclear ophthalmoplegia is an eye movement disease in which the inability to move both eyes to one side of the face equally. It is caused by the damage of a group of nerve fiber cells (medial longitudinal fasciculus) that attach to the brain. This disease can affect one or both eyes, but they can raise and lower their eyes, not inward. Depending on the underlying condition that caused it, the treatment for internuclear ophthalmoplegia will vary. Daily medicines, injectable medications, physical therapy, infusions, and techniques for controlling pain are the methods of management of these diseases infarction, like a stroke. Making routine visits to the eye doctor is the greatest way to avoid developing eye problems or to stop them from getting worse.Therefore, it is essential to take good care of the eyes so they continue to function normally for a very long time.

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Dr. Asha Juliet Barboza
Dr. Asha Juliet Barboza

Ophthalmology (Eye Care)

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