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Gastrointestinal Symptoms in Long COVID - An Insight

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Acute diarrhea and anorexia are among the most common mild and self-limiting GI symptoms linked to COVID-19.

Written by

Dr. Palak Jain

Medically reviewed by

Dr. Ghulam Fareed

Published At April 10, 2024
Reviewed AtMay 3, 2024

Introduction

Initially, the SARS-CoV-2 virus was thought to be a lung illness before it spread worldwide and started an epidemic. It was later shown that most organs, including the digestive system, can be impacted by the illness brought on by this virus (SARS-CoV-2). Long-COVID refers to the infection's long-term effects, which are still being gradually identified. In addition to elevated liver enzymes, the main long-term symptoms include diarrhea, nausea, vomiting, and abdominal pain.

Individuals with long-term consequences are more likely to suffer chronic illnesses. Hundreds of millions of individuals worldwide are infected with COVID-19. The GI tract, which includes the stomach, small intestines, colon, and esophagus, is infected by the same virus particles that cause lung disease. Abdominal discomfort and diarrhea may result from this; these symptoms may or may not go away when a person heals.

What Happens to the Gut During a COVID Infection?

However, a significant portion of the symptoms caused by the coronavirus can involve digestive issues. Approximately one in five individuals exhibit symptoms connected to their digestive system; the most common ones are diarrhea, abdominal pain, appetite loss, and nausea, which can occasionally be accompanied by vomiting.

These symptoms persist for several months in several individuals. Stomach distress can be a classic indicator of COVID-19 and other symptoms (such as fever, dry cough, and shortness of breath). When a person tested positive for COVID-19, an estimated 1 in 5 experienced at least one gastrointestinal symptom, such as vomiting, diarrhea, or stomach pain.

What is Long COVID?

Most COVID-19 patients will recover, but researchers are starting to identify a subset of patients whose health deteriorates over time. Prolonged COVID-19 side effects that have been well-reported include fatigue, dyspnea (difficulty breathing), an irregular heartbeat, and muscle aches. However, not many people, even in the medical community, know that persistent diarrhea and stomach pain are possible long-term COVID-19 symptoms.

Why Might the Gut Be Involved in Long COVID?

The reason why COVID-19 infection may result in persistent gastrointestinal problems is unknown. A well-known condition, post-infectious irritable bowel syndrome (IBS), which can develop following the stomach flu (gastroenteritis), offers one potential clue.

There may be a shift in gut-brain signaling long after the pathogen has disappeared. The gut's intricate nerve network facilitates communication between its components and links it to the brain. These nerves command digestive juice production to bodily organs. A higher risk of acquiring a new GI problem following COVID infection was observed in those assigned to the feminine gender at birth as well as those with a history of depression or anxiety, according to a study on post-COVID GI symptoms (for instance, diarrhea, vomiting, or stomach discomfort). It did not appear that having GI symptoms during the initial COVID-19 infection increased the likelihood of developing GI problems on the road.

Since irritable bowel syndrome (IBS) is typically characterized by digestive distress without the presence of gut pathology, it is thought to be a dysfunction of the gut-brain axis. Several studies have documented changes in the gut microbiota. The gut microbiome is known to play a role in both promoting health and contributing to the development of a number of diseases, including those of the digestive system (IBS, IBD, Celiac disease), the liver (non-alcoholic steatohepatitis), the nervous system, the metabolism (obesity, diabetes), the autoimmune system, and, last but not least, cancer. Dysbiosis, or alterations in the makeup and function of the intestinal microbiome, can alter the immune system, intestinal permeability, and motility of the digestive tract, ultimately resulting in a proinflammatory state that lasts a long time.

The potential for developing Clostridium difficile colitis is another consequence of COVID-19 infection. One of the most prevalent infections obtained in hospitals is Clostridium difficile colitis. Hospitalization, aging, and antibiotic exposure are important risk factors for Clostridium difficile infection. All patients with bilateral pneumonia related to SARS-CoV-2 should get broad-spectrum antibiotics as part of their recommended course of treatment, yet these drugs are highly linked to Clostridium difficile infection.

What One Should Do to Prevent Gastrointestinal Symptoms in Long COVID?

It is not a sign that someone has COVID-19 if they have vomiting, nausea, or diarrhea. Nonetheless, paying close attention to the symptoms during this pandemic is advisable, particularly if one has a medical condition that increases the risk of infection or resides in a region where the coronavirus is common.

  • Stay at Home - Most individuals with positive coronavirus tests suffer mild symptoms and recover independently without medical intervention. Refrain from leaving the house unless necessary, like in case of an emergency medical visit.

  • Maintain a "sick" bathroom and bedroom. If an individual lives with others, try to use a separate bathroom for oneself to avoid passing on germs from the waste.

  • Frequently clean and disinfect surfaces. This includes the flush and seat handles, phones, counters, doorknobs in bathrooms, and other items people frequently come into contact with.

  • Hands should be cleaned often. Using soap and water for at least 20 seconds is preferable, especially before eating or cooking and after using the restroom, blowing the nose, or sneezing. A hand sanitizer containing at least 60 percent alcohol is the next best option.

  • Sip a Lot of Liquids - It is critical to replenish lost fluids if one has diarrhea or vomiting. A store-bought oral rehydration solution is the best option because it contains sugar and salt, which the body loses when diarrhea occurs. Alternatively, salty crackers and broths can be consumed with diluted fruit juices or soft beverages.

  • Consume Bland Food - Try eating items that can help curb the desire to urinate and restore the body's necessary supply of carbs, such as toast, bananas, white rice, and applesauce. Oatmeal, roasted or boiled potatoes, and skinless baked chicken are more options.

Conclusion

Any virus that enters the body can multiply and damage healthy cells. The cells that line the airways are the primary target of Covid-19. This can cause pneumonia and make breathing difficult for the person. However, scientists believe the disease may potentially damage liver and digestive system tissue. The most prevalent symptom is appetite loss, followed by loss of taste and smell.

Diarrhea can affect up to 34 percent of people and lasts for an average of 5 days. Refrain from facing the issue alone or being afraid to take action if it continues. If the quality of life is being negatively impacted or daily activities are being interfered with by significant discomfort or changes in bowel motions, get help. See the doctor about the potential diagnosis of prolonged COVID-19 as a cause of the ongoing gastrointestinal issues.

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Dr. Ghulam Fareed
Dr. Ghulam Fareed

Medical Gastroenterology

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