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Treatment of Cholera in Infants- Causes,Clinical Features,Treatment,Prevention

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Cholera is acute diarrhea caused by bacterial infection. It is caused by the consumption of contaminated food and water.

Written by

Dr. Kriti Singh

Medically reviewed by

Dr. Veerabhadrudu Kuncham

Published At November 17, 2022
Reviewed AtNovember 17, 2022

Introduction

It is an acute infectious disease caused by the bacteria Vibrio cholerae. This bacteria releases toxins in the small intestine, causing the body to secrete an enormous amount of water resulting in rapid loss of water and electrolytes. It is caused by the ingestion of contaminated food and water. It is a highly virulent disease that causes watery diarrhea. If the bacteria are in a small amount in the body, it is killed by acid in the stomach; however, bacteria remain in stool for seven to fourteen days. Therefore, proper maintenance of sanitation and hygiene helps in the prevention of this infection.

What Are the Causes of Cholera in a Child?

Vibrio cholerae bacteria cause cholera. It is found in contaminated food and water and spreads to the feces of an infected person. The bacteria release a toxin in the small intestines that causes severe diarrhea. The child may get infected by water or eat raw uncooked food contaminated with bacteria.

Following are the various modes of transmission.

  • Food and drink items are sold outside with improper hygiene.

  • Consumption of vegetables grown with the help of human waste.

  • Raw and undercooked seafood from polluted sewage.

  • Water supplies from municipal sources.

  • Unsanitary disposal of stool.

What Are the Clinical Features of Cholera?

The signs and symptoms of cholera begin after six days of the infection. Most commonly, symptoms range from mild to moderate, but sometimes, it gets severe. The most common clinical manifestation is acute diarrhea and vomiting, resulting in severe dehydration. The infected child with mild or without symptoms can spread the infection.

The bacteria is present in feces for ten days, approximately after the infection. The bacteria typically have an incubation period of one to two days. The characteristic symptom of this infection is stool presenting with a fishy odor, also known as cholera gravis. If it is not treated correctly, it can lead to hypovolemic shock. Children who have weak immune systems are at significant risk of severe complications.

Following are the various signs and symptoms found in this infection.

  • There is the presence of severe watery diarrhea known as "rice-water stools."

  • There is the presence of recurrent vomiting.

  • Severe dehydration due to water and electrolyte loss.

  • The heart rate of the child is rapid.

  • The blood pressure of the child is low.

  • The mucous membrane appears to be dry.

  • There is the presence of muscle cramps.

  • There is a loss of skin elasticity.

  • The stool output can reach one liter per hour.

  • There is the presence of abdominal discomfort.

  • There is a presence of low urine output.

  • The child appears to be irritable.

What Are the Treatment Plans for Cholera?

The infection needs immediate care and treatment as it can cause severe dehydration. The primary goal of the treatment is to manage dehydration and treat fluid and electrolyte loss. For mild to moderate symptoms, fluid intake is advised for hydration; however, if there is a severe infection, the child is recommended to get intravenous fluid. In addition, the adjunctive therapy of antibiotics is indicated in children suffering from severe diseases.

Following are the various treatment plans for the treatment of cholera.

  • Assessment of Loss of Fluid - It can be assessed by physical examination of skin, mouth, eyes, and pulse rate. According to the world health organization, the degree of volume loss is categorized as mild to severe according to the physical findings. For estimating the volume loss in stools, cholera clots are used. There can be a loss of ten milliliters per kilogram of fluid in each stool or vomiting episode.

  • Oral Rehydration Solution - Most infected children can be treated with the help of an oral rehydration solution. The oral rehydration solution is administered as a standard sachet dissolved in one liter of clean water. The recommended dose for children suffering from mild to moderate dehydration is approximately five liters of oral rehydration solution. It helps in replacing fluid and electrolyte loss caused by vomiting and diarrhea.

  • Intravenous Fluid - Intravenous fluid is indicated in children suffering from severe volume depletion and hypovolemic shock. There is immediate administration of fluid to restore circulation rapidly. Initially, the fluid volume administered is 100 milliliters per kilogram gram every three hours. The most commonly used intravenous fluid is ringer lactate solution.

  • Antibiotic Solution - Antibiotics are used as an adjunct to the hydration treatment of the child. It is indicated in moderate to severe volume depletion. Antibiotic therapy shortens the duration of diarrhea and reduces volume loss by up to fifty percent. The choice of antibiotics depends upon the availability and pattern of the resistance. The commonly used antibiotics are tetracycline, furazolidone, chloramphenicol, doxycycline, and sulfaguanidine. The doxycycline is given at a dose of 300 milligrams.

  • Zinc - It is a necessary adjunctive therapy for children under the age of five years. It reduces the duration of diarrhea. In addition, it helps in the prevention of fluid loss in children.

How Can Parents Prevent the Spread of Cholera in Their Children?

Parents can practice a few measures to prevent cholera in their children.

  • Parents should ensure a clean water supply and proper sanitization to prevent cholera.

  • If the child travels with their parents, boiled and chemically disinfected water should be used.

  • The children's hands should be adequately cleaned before eating food.

  • The eating utensils should be washed properly.

  • The fruits and vegetables should be washed properly before eating.

  • The surface of tins or cans containing food and beverages should be adequately cleaned.

Conclusion

It is a bacterial infection that causes acute diarrhea. Diarrhea caused by this infection can range from mild to moderate. This infection is severe because it causes water and electrolyte loss. It is a global threat to public health and indicates a lack of social development. If left untreated, it can cause severe consequences. Proper sanitation, disinfection, and safe water can prevent this infection. Oral cholera vaccines can help in controlling cholera outbreaks. In case of extreme conditions, rapid treatment with antibiotics and intravenous fluid is indicated. Parents should take care of the hygiene and environment of the child.

Frequently Asked Questions

1.

What Are the Symptoms of Cholera in Children?

The symptoms of cholera in children are mild to moderate stomach pain. In severe cases, there is vomiting and diarrhea. The diarrhea is watery. All these signs lead to dehydration in children. Other signs are rapid heart rate, dry mucous membranes, decreased blood pressure, and muscle cramps. Immediate treatment for dehydration is essential as it leads to shock and death.

2.

Does Cholera Infection Occur in Infants?

Cholera infections rarely occur in infants. The infection is rare in children below two years of age. The signs are mild diarrhea. The treatment is rehydration therapy. That is through oral or intravenous route hydration. This is the primary management of cholera.

3.

How Do the Stools After a Cholera Infection Appear?

In the earlier stages of the infection, the stools consist of fecal matter and bile. The distinguishing feature of cholera infection is the passage of rice-water stool. There is watery diarrhea with mucus flecks. The odor of the stools is fishy.

4.

Does the Cholera Infection Subside on Its Own?

The cholera infection subsides on its own in a few days. The symptoms subside in three to six days after onset. But if there is severe diarrhea which causes severe dehydration,  there is a need for medical attention and for intravenous fluid administration.

5.

What Is the Diagnosis of Cholera Infection?

The correct method to confirm the cholera infection is rapid cholera dip tests. The identification of bacteria in a stool sample. These tests help physicians conclude quickly. Quick confirmation and timely management help to decrease the mortality rates. The signs of cholera are similar to other bacterial infections.

6.

What Is the Treatment for Cholera Infection?

Hydration is the primary treatment for cholera through the oral or intravenous route. Along with hydration, treatment with antibiotics is recommended for severely affected patients. Antibiotic treatment is also recommended for patients severely affected by dehydration who continue to pass a large stool volume during rehydration treatment.

7.

What Is the Incubation Period of Cholera Infection?

The cholera infection lasts for about two to five days. Individuals who have mild to moderate cases usually get better within a week. Even individuals with severe cholera cases recover fully in a week or so if medical attention is provided.

8.

What Are the Stages of the Cholera Infection?

The typical case of cholera shows three stages, which are:
- Stage of evacuation.
- Stages of collapse: 
-- Stage of collapse 
-- Stage of recovery.

9.

Is Cholera Infection Life-Threatening?

The cholera infection can become life-threatening. In the most adverse cases, excess fluids and electrolytes are rapidly lost, which can lead to death within a short span. Individuals who do not receive immediate treatment can die because of dehydration and shock.

10.

How Long Does It Take for the Symptoms to Show Post the Infection?

After the cholera infection, typically, it takes two to three days for the occurrence of symptoms. Cholera is a bacterial infection that occurs due to consumption of contaminated water. The period can range from a few hours to five days for the symptoms to appear.

11.

At What Age Is the Cholera Vaccine Injected?

The cholera vaccine is injected into individuals after the age of one year. Two doses of cholera vaccines must be injected to protect against cholera for three years. Between the two doses of the cholera vaccine, there should be a minimum of two to three weeks delay. The single dose gives only short-term protection. The cholera vaccines are Shanchol and Euvichol.

12.

Why Are Children Vaccinated Against Cholera?

The children are vaccinated from the age of one year against cholera. The vaccination decreases the risk of death from cholera by fifty percent in the first year. In addition, vaccines produce immunity in the body.

13.

Are Children Vaccinated Against Cholera?

The children are vaccinated against cholera. In the case of oral vaccines, two to three doses are recommended. The duration of protection is six months for two to five years in children and two years in adults. A single-dose vaccine is recommended for those traveling to cholera-prone areas.

14.

Will Cholera Vaccine Give Lifelong Protection?

The cholera vaccine offers protection against cholera for two years after a single shot and three to four years of protection with a booster dose. In addition, the vaccines decrease the risk of death from cholera by fifty percent in the first year after vaccination.
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Dr. Veerabhadrudu Kuncham
Dr. Veerabhadrudu Kuncham

Pediatrics

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