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Synovial Chondromatosis - Causes, Symptoms, and Treatment

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Synovial chondromatosis affects joints and causes pain and swelling. Read this article to learn more.

Medically reviewed by

Dr. Anuj Nigam

Published At November 14, 2023
Reviewed AtNovember 14, 2023

Introduction-

Synovial chondromatosis is a rare benign condition affecting the joints' synovial lining. The formation of multiple cartilaginous nodules within the synovial membrane characterizes it. These nodules can detach and become loose bodies within the joint, causing pain, swelling, and a limited range of motion.

What Are the Causes of Synovial Chondromatosis?

The exact cause of synovial chondromatosis is unknown. Still, it is believed to be caused by a genetic mutation that leads to the abnormal growth and proliferation of chondrocytes, which produce cartilage. The knobs in synovial chondromatosis comprise the hyaline ligament, which covers the closures of bones in a joint. It is unclear why these nodules form within the synovial membrane, but some experts believe that trauma or inflammation may play a role in their development.

What Are the Symptoms of Synovial Chondromatosis?

The symptoms of synovial chondromatosis vary depending on the location and severity of the nodules. Sometimes, the nodules may be asymptomatic and discovered incidentally in imaging studies. However, when they occur, the most common symptoms include joint pain, swelling, and a limited range of motion. Other common symptoms include:

  1. Joint Stiffness and Clicking: The presence of nodules within the joint can cause stiffness and clicking sounds during movement.

  2. Locking of the Joint: If a nodule becomes dislodged from the synovial membrane, it can become lodged within the joint, causing it to lock in place.

  3. Joint Instability: The presence of multiple nodules can cause instability within the joint, making it difficult to bear weight or perform certain activities.

How to Diagnose Synovial Chondromatosis?

The diagnosis of synovial chondromatosis begins with a thorough physical examination and medical history. However, when synovial chondromatosis can be exacerbated by chronic joint inflammation, such as in gout or rheumatoid arthritis, they occur as the most common symptoms include joint pain, swelling, and a limited range of motion. Sometimes, a synovial biopsy may be performed to confirm the diagnosis.

Who Is at Risk of Synovial Chondromatosis?

Synovial chondromatosis is rare, and the exact cause is not fully understood. However, some factors can increase the risk of developing synovial chondromatosis. These risk factors include:

  1. Age: Synovial chondromatosis can occur more commonly in people aged between 30 to 50.

  2. Gender: The condition is more prevalent in men than women.

  3. Joint Injury or Trauma: People with joint injury or trauma, such as a fracture, dislocation, or repetitive stress injury, are at higher risk of developing synovial chondromatosis.

  4. Joint Inflammation: Synovial chondromatosis can be exacerbated by chronic joint inflammation, such as in gout or rheumatoid arthritis.

  5. Genetic Factors: Some genetic factors may make certain individuals more susceptible to developing synovial chondromatosis.

Not everyone with these risk factors will get synovial chondromatosis; some people can still get it even if they do not have any known risk factors. Synovial chondromatosis is typically sporadic, with no known cause or risk factor. People should consult a doctor for a proper diagnosis and treatment if they suffer from risk factors and experience joint pain, swelling, or stiffness. Early intervention can help prevent further joint damage and complications associated with synovial chondromatosis.

What Are the Complications of Synovial Chondromatosis?

Synovial chondromatosis is a rare, benign condition that can cause several complications if left untreated. These complications can affect the function and mobility of the affected joint and may require more invasive treatment to address. Here are some of the common complications associated with synovial chondromatosis:

  1. Joint Damage: The presence of multiple nodules within the synovial membrane can cause joint damage over time. As the nodules grow and break off, they can cause cartilage damage, bone erosion, and inflammation, leading to pain, swelling, and stiffness. If left untreated, this damage can progress to osteoarthritis and joint deformity.

  2. Joint Instability: Multiple nodules within the synovial membrane can also cause joint instability, making it difficult to bear weight or perform certain activities. This insecurity can build the gamble of falls and cracks, further convoluting the condition.

  3. Nodule Detachment: Sometimes, the nodules within the synovial membrane may detach and become free-floating within the joint space. These solitary nodules can cause joint locking, limiting the range of motion and causing pain and discomfort.

  4. Cancerous Transformation: While synovial chondromatosis is a benign condition, in rare cases, the nodules within the synovial membrane can undergo malignant transformation and become cancerous. When the nodules have been present for a considerable amount of time and have caused extensive joint damage, this transformation is more likely to occur.

  5. Post-Surgical Complications: The surgical removal of the nodules and repair of the joint can also cause complications. These can include infection, bleeding, nerve damage, and joint stiffness. These complications can be minimized with proper surgical technique and post-operative care.

Synovial chondromatosis can cause several complications if left untreated. These complications can affect the function and mobility of the affected joint and may require more invasive treatment to address. On experiencing joint pain, swelling, or stiffness, one must seek help immediately to avoid further harm and complications.

What Are the Treatments of Synovial Chondromatosis?

The treatment of synovial chondromatosis depends on the location and severity of the nodules and the symptoms they are causing. Conservative management, such as rest, ice, and anti-inflammatory medications, may be recommended in mild cases. Physical therapy can also be helpful to improve joint mobility and strength.

Surgical intervention is the treatment of choice in severe cases. The objective of the medical procedure is to eliminate the free bodies and some other knobs inside the joint and fix any harm that might have happened to the joint. Recovery takes time from a few weeks to months after surgery.

Joint replacement surgery may be necessary in rare cases where the condition is very severe or has recurred despite surgery. This involves the removal of the damaged joint and the insertion of an artificial joint.

What Is the Prognosis of Synovial Chondromatosis?

The prognosis for synovial chondromatosis varies depending on the location and severity of the nodules and the success of the treatment. In mild cases, conservative management can be very effective, and the condition may resolve independently. Surgical intervention may be necessary in more severe cases, but the long-term outcomes are generally good.

How to Prevent Synovial Chondromatosis?

Since the exact cause is unknown, there is currently no known method for preventing synovial chondromatosis. However, avoiding joint trauma and maintaining a healthy weight may assist in lowering the likelihood of the condition developing.

Conclusion:

Synovial chondromatosis is a rare benign condition affecting the joints' synovial lining. The formation of multiple cartilaginous nodules within the synovial membrane characterizes it. The specific reason for the condition is obscure. However, it is accepted to be made by a hereditary change that drives chondrocytes' abnormal development and expansion. The symptoms of synovial chondromatosis can vary depending on the location and severity of location and severity of nodules.

Dr. Anuj Nigam
Dr. Anuj Nigam

Orthopedician and Traumatology

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