HomeHealth articleshidradenitis suppurativaWhat Are the Causes of Hidradenitis Suppurativa in Elderly?

Hidradenitis Suppurativa in Elderly People

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The older HS population saw a higher familial prevalence of HS and a female-to-male ratio of 1.7:1.0. It is not uncommon for older people to have HS.

Written by

Swetha. R.

Medically reviewed by

Dr. Rajesh Gulati

Published At January 3, 2024
Reviewed AtJanuary 19, 2024

Introduction

Hidradenitis suppurativa is a debilitating skin disorder characterized by painful, recurrent abscesses and boils in areas with a high density of apocrine sweat glands, such as the axilla, groin, and perianal regions. While HS primarily affects young adults, it can also manifest in the elderly, although its occurrence is relatively rare.

What Are The Symptoms Of Hidradenitis Suppurativa?

The main symptom of Hidradenitis suppurativa is the development of painful, inflamed nodules or lumps in areas with apocrine sweat glands. These nodules can evolve into abscesses filled with pus and cause significant discomfort. In the elderly, these symptoms can be more challenging to manage due to age-related issues like frailty. HS is characterized by the recurrent formation of boils, which may rupture, discharge pus, and heal with scarring. The recurrence of these boils can lead to chronic discomfort and reduced quality of life in elderly individuals.

Over time, tunnels or sinus tracts may develop under the skin, connecting abscesses. These structures contribute to the chronic nature of HS and can be painful and distressing. As HS progresses, it often leads to significant scarring, which can be more pronounced and problematic in skin elasticity due to the age changes in the elderly. The pain associated with HS can be severe and persistent. In elderly people, this pain may be exacerbated by reduced mobility, frailty, and other age-related factors. In the elderly, this can be especially concerning due to potential mobility limitations and the psychosocial impact of the condition.

Open abscesses and sinus tracts create entry points for bacteria, increasing the risk of secondary skin infections. In elderly individuals, the immune system may be less robust, making them more susceptible to these infections. Some individuals with HS may experience systemic symptoms such as fever and malaise during flare-ups. In elderly individuals, these symptoms can be more concerning due to the potential impact on overall health. HS in elderly individuals can sometimes present with atypical symptoms or locations.

What Are the Causes of Hidradenitis Suppurativa?

Genetic factors are known to play a role in the development of HS. If a family member has HS, there is an increased risk of developing the condition. In elderly individuals, a genetic predisposition may still be a factor in the development of HS. Hormonal fluctuations can influence the onset and severity of HS. In older adults, hormonal changes, such as those associated with menopause in women, can potentially impact the condition. Obesity is a known risk factor for HS, and it is more prevalent in older age groups. Excess body weight can lead to friction and increased sweating in skin folds, which are known triggers for HS. HS is considered an autoimmune condition, and immune system dysfunction can contribute to its development. Age-related changes in the immune system may play a role in the occurrence of HS in elderly individuals.

Elderly people often have a higher prevalence of comorbid conditions like diabetes and metabolic syndrome. These conditions are associated with inflammation, and they may contribute to the development or exacerbation of HS. Lifestyle choices, such as poor hygiene or excessive smoking, can also contribute to the development of HS in elderly individuals. Age-related changes in skin elasticity and structure may make the skin more prone to friction and irritation, which can exacerbate HS.

How to Diagnose Hidradenitis Suppurativa in Elderly?

The initial step in diagnosing HS is a thorough clinical examination. A healthcare provider, often a dermatologist, will visually assess the affected areas. In elderly patients, the examination should be performed with sensitivity to age-related changes in the skin. Gathering a detailed medical history is essential. This includes asking about the onset of symptoms, the location and progression of lesions, family history of HS, and any relevant comorbidities. Because HS can mimic other skin conditions, such as folliculitis, abscesses, or hidradenitis-like presentations of other diseases, a differential diagnosis should be considered to rule out these conditions.

Skin biopsies or cultures may be necessary to differentiate between HS and other disorders. In some cases, the Hurley staging system may be used to assess the severity of HS. It categorizes HS into three stages based on the extent and severity of the disease. Treatment decisions are made at this stage. In severe or complicated cases, imaging studies such as ultrasound, magnetic resonance imaging (MRI) may be used to assess the extent of the disease and the presence of tunnels or abscesses under the skin.

Biopsy of skin is used to confirm the diagnosis of HS and rule out other conditions. A biopsy involves taking a small sample of affected skin tissue and examining it under a microscope. The characteristic findings in an HS biopsy include inflammation, tissue destruction, and abscess formation. While there are no specific blood tests to diagnose HS, laboratory tests may be conducted to assess the patient's overall health, including the protein C-reactive protein (CRP) and the density of erythrocytes (ESR), two indicators of inflammation.

What Are Therapeutic Management Strategies of Hidradenitis Suppurativa in the Elderly?

Encourage regular cleansing of the affected areas to prevent bacterial overgrowth. Weight loss, if necessary, can reduce friction and sweating, which are known triggers for HS. Guidance on dietary modifications and exercise may be beneficial. Antibiotics, such as tetracycline, clindamycin, or rifampin, can help control inflammation and infection. In elderly patients, antibiotic use should be monitored for potential side effects and drug interactions. Topical antiseptics or antimicrobial solutions may be recommended for daily wound care.

Healthcare providers may perform incision and drainage for larger abscesses to relieve pain and reduce infection. Intralesional corticosteroid injections can help control inflammation and reduce the size of nodules. Laser therapy, such as carbon dioxide lasers, may be used to manage severe or recurrent cases of HS. Surgical excision or wide local excision may be necessary in cases of extensive scarring and tunnels, but this is typically reserved for severe cases and must be carefully considered in older patients.

Elderly patients may experience significant pain due to HS. Adequate pain management is essential for improving their quality of life. Pain relief options, such as non-opioid analgesics or neuropathic pain medications, should be considered. Guide wound care to prevent secondary infections. Appropriate dressings and bandages can help keep the affected areas clean and facilitate healing.

Conclusion

Age-related factors, hidradenitis suppurativa in the elderly, pose unique obstacles that complicate diagnosis and management. When treating and supporting older people with HS, healthcare professionals should be mindful of these distinctions and develop a comprehensive strategy. It is possible to enhance the quality of life for persons affected by HS in their older years by attending to both the skin condition and the individual's specific requirements. More knowledge and study are required to better understand and manage HS in the senior population.

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Swetha. R.
Swetha. R.

Pharmacology

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