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HomeAnswersMedical GastroenterologybilirubinOther than hepatitis, what can cause increased bilirubin levels?

My bilirubin level keeps on increasing with negative hepatitis test. What is my problem?

The following is an actual conversation between an iCliniq user and a doctor that has been reviewed and published as a Premium Q&A.

Answered by

Dr. Ajeet Kumar

Medically reviewed by

Dr. Vinodhini J.

Published At May 31, 2020
Reviewed AtJanuary 11, 2024

Patient's Query

Hello doctor,

I have jaundice. My biliurubin was 7.5 three weeks ago. I went to the doctor for jaundice. Weekly blood tests as of three weeks show bilirubin has been increasing. Hep test shows I do not have hepatitis. Ultrasound says no tumor bile duct coverage or stones. I took a CT scan and the results show there is no obstruction and pancreas is normal. In other words my body parts are normal.

In two weeks, I will see a gastroenterologist. What do you think I have? I will probably have more blood tests this Monday to check bilirubin levels. I am currently on Hydroxyzine HCl.

Answered by Dr. Ajeet Kumar

Hello,

Welcome to icliniq.com.

Well, your US (ultrasound) and CT (computed tomography) scan are normal which is kind of satisfying to me. Of course you suppose to have more blood tests to confirm the origin of this jaundice.

Hepatitis, although common, but they are not the only one to cause liver problem there are many other causes such as nonhepatotrophic virus infections as herpes virus, Ebstein Barr virus, cytomegalovirus. Non-viral causes are Wilson hemochromatosis, alpha-1 trypsin deficiency. The causes of predominantly raised bilirubin (jaundice) with normal CT scan suggest microscopic primary sclerosing cholangitis, primary biliary cholangitis benign and progressive familial intrahepatic cholestasis. The hepatologist will start from blood tests first and at times can be recommended liver biopsy if the blood test does not serve the purpose.

It is possible that you have one of the above or not any of the above. The reason is it is always important to have a clinical history then targeted blood tests and examinations before a hepatologist is able to give you one word specific diagnosis.

The Probable causes

Deranged liver function tests.

Probable diagnosis

Deranged liver function tests.

Treatment plan

After establishing a diagnosis.

Regarding follow up

Follow up if want to provide more information and discuss the right approach to each and everyone of above disorders.

Same symptoms don't mean you have the same problem. Consult a doctor now!

Dr. Ajeet Kumar
Dr. Ajeet Kumar

Medical Gastroenterology

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